Protein Tyrosine Kinases

From Inhibitors to Useful Drugs

Inbunden, Engelska, 2005

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This volume presents a comprehensive overview on the drug discovery processes aimed at generating inhibitors for the treatment of malihnancies believed to be dependent on the gain of function of protein tyrosine kinases (RTKs). Specific topics include Src as a target for pharmaceutical intervention, JAK kinases in leukemias/lymphomas, platelet-derived growth factor, structural biology of PTKs, PI3-kinase inhibition, and phosphoproteomics in drug discovery and development.

Produktinformation

Utgivningsdatum2005-09-01
Mått155 x 235 x 23 mm
Vikt767 g
FormatInbunden
SpråkEngelska
SerieCancer Drug Discovery and Development
Antal sidor290
Upplaga2006
FörlagHumana Press Inc.
ISBN9781588293848

Tillhör följande kategorier

Biokemi inom Naturvetenskap och teknik

Protein Tyrosine Kinases as Targets for Cancer and Other Indications.- Inhibitors of Signaling Interfaces.- PI3-Kinase Inhibition.- Src as a Target for Pharmaceutical Intervention.- Activated FLT3 Receptor Tyrosine Kinase as a Therapeutic Target In Leukemia.- JAK Kinases in Leukemias, Lymphomas, and Multiple Myeloma.- Glivec® (Gleevec®, Imatinib, STI571).- Platelet-Derived Growth Factor.- Structural Biology of Protein Tyrosine Kinases.- Testing of Signal Transduction Inhibitors in Animal Models of Cancer.- Phosphoproteomics in Drug Discovery and Development.