Protein Misfolding

Rossen Donev received his PhD degree in 1999 from the Institute of Molecular Biology, Bulgarian Academy of Sciences. He did postdoctoral training at Imperial Cancer Research Fund, UK (renamed after the merger with Cancer Research Campaign to Cancer Research UK, London Research Institute) and Cardiff University. In 2007 he was awarded a New Investigator Grant Award from the Medical Research Council (UK) to establish himself as an independent Principle Investigator. In 2010 Dr. Donev was appointed Senior Lecturer at Swansea University. In 2016 Dr. Donev joined MicroPharm Ltd (UK) where currently he is Head of Research. He has published more than 60 research papers, chaired scientific meetings and given invited plenary talks. Rossen Donev has consulted on projects related to development of treatments for neurodevelopmental disorders and cancer therapies. He serves as Editor-in-Chief of the Advances in Protein Chemistry and Structural Biology and on editorial board of several other journals. His research interests include signaling pathways involved in neuropsychiatric disorders and tumor escape from the immune system, and development of therapeutic strategies for their treatment. More recently he has focused on development of immunotherapeutics for non-systemic applications.

• 1. Theoretical and computational advances in protein misfoldingParbati Biswas2. Combining molecular dynamics simulations and experimental analyses in protein misfoldingHolger Wille, Lyudmyla Dorosh, Sara Amidian, Gerold Schmitt-Ulms, and Maria Stepanova3. Mass spectrometric approaches for profiling protein folding and stabilityJoseph C. Genereux4. The intrinsic and extrinsic factors that contribute toproteostasis decline and pathological protein misfolding 145Elise A. Kikis5. Functional and dysfunctional folding, association andaggregation of caseinsJohn A. Carver and Carl Holt6. Protein misfolding in endoplasmic reticulum stress with applications to renal diseases Samera Nademi and Jeffrey G. Dickhout7. Misfolding of vasopressin receptors: biased agonist pharmacochaperones as potential therapeutics Christiane Mendre and Bernard Mouillac8. LOXL1 folding in exfoliation glaucoma Audrey M. Bernstein, Robert Ritch, and J. Mario Wolosin9. Liquid-liquid phase transitions and amyloid aggregation in proteins related to cancer and neurodegenerative diseases 289Guilherme A.P. de Oliveira, Yraima Cordeiro, Jerson L. Silva, and Tuane C.R.G. Vieira10. Cytotoxic species in amyloid-associated diseases: Oligomers or mature fibrilsMohammad Khursheed Siddiqi, Sadia Malik, Nabeela Majid, Parvez Alam, and Rizwan Hasan Khan11. Misfolded proteins as a therapeutic target in Alzheimer’s diseaseS. Imindu Liyanage, Donald F. Weaver12. Influence of the reducing environment in the misfolding of wine proteins Paolo Ruzza, Claudia Honisch, Matteo Marangon, Andrea Curioni, Alan Bakalinsky, and Simone Vincenzi