Protein Kinases in Drug Discovery

Rossen Donev received his PhD degree in 1999 from the Institute of Molecular Biology, Bulgarian Academy of Sciences. He did postdoctoral training at Imperial Cancer Research Fund, UK (renamed after the merger with Cancer Research Campaign to Cancer Research UK, London Research Institute) and Cardiff University. In 2007 he was awarded a New Investigator Grant Award from the Medical Research Council (UK) to establish himself as an independent Principle Investigator. In 2010 Dr. Donev was appointed Senior Lecturer at Swansea University. In 2016 Dr. Donev joined MicroPharm Ltd (UK) where currently he is Head of Research. He has published more than 60 research papers, chaired scientific meetings and given invited plenary talks. Rossen Donev has consulted on projects related to development of treatments for neurodevelopmental disorders and cancer therapies. He serves as Editor-in-Chief of the Advances in Protein Chemistry and Structural Biology and on editorial board of several other journals. His research interests include signaling pathways involved in neuropsychiatric disorders and tumor escape from the immune system, and development of therapeutic strategies for their treatment. More recently he has focused on development of immunotherapeutics for non-systemic applications.

• 1. Transporter proteins and its implication in human diseasesRitika Kabra and Shailza Singh2. Protein kinase CK2 inhibition as a pharmacological strategyChristian Borgo and Maria Ruzzene3. Emerging role of protein kinases in diabetes mellitus: From mechanism to therapyPreeti Gupta, Aaliya Taiyab, and Md Imtaiyaz Hassan4. Dual roles of ATP-binding site in protein kinases: Orthosteric inhibition and allosteric regulationMingyu Li, Ashfaq Ur Rehman, Yaqin Liu, Kai Chen, and Shaoyong Lu5. Pseudokinases: Prospects for expanding the therapeutic targets armamentariumNayana Devang, Adyashree Pani, and G.K. Rajanikant6. Chemogenomics and bioinformatics approaches for prioritizing kinases as drug targets for neglected tropical diseasesJoyce Villa Verde Bastos Borba, Arthur Carvalho Silva, Marilia Nunes Nascimento Lima, Sabrina Silva Mendonca, Nicholas Furnham, Fabio Trindade Maranhão Costa, and Carolina Horta Andrade7. Targeting malaria protein kinasesG.C. Cassiano, T.A. Tavella, M.N. Nascimento, D.A. Rodrigues, P.V.L. Cravo, Carolina Horta Andrade, and Fabio Trindade Maranhão Costa8. Yeast-based high-throughput screens for discovery of kinase inhibitors for neglected diseasesT.A. Tavella, G.C. Cassiano, Fabio Trindade Maranhão Costa, P. Sunnerhagen, and E. Bilsland9. Structural studies of full-length receptor tyrosine kinases and their implications for drug designAdam Bajinting and Ho Leung Ng