Protein Interactions

The Molecular Basis of Interactomics

Inbunden, Engelska, 2022

Av Volkhard Helms, Olga V. Kalinina, Saarbr¿cke) Helms, Volkhard (Universit¿t des Saarlandes

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Protein Interactions A fundamental guide to the burgeoning field of protein interactions From enzymes to transcription factors to cell membrane receptors, proteins are at the heart of biological cell function. Virtually all cellular processes are governed by their interactions, with one another, with cell bodies, with DNA, or with small molecules. The systematic study of these interactions is called Interactomics, and research within this new field promises to shape the future of molecular cell biology. Protein Interactions goes beyond any existing guide to protein interactions, presenting the first truly comprehensive overview of the field. Edited by two leading scholars in the field of protein bioinformatics, this book covers all known categories of protein interaction, stable as well as transient, as well as the effect of mutations and post-translational modifications on the interaction behavior. Protein Interactions readers will also find: Introductory chapters on protein structure, conformational dynamics, and protein-protein binding interfacesA data-driven approach incorporating machine learning and integrating experimental data into computational modelsAn outlook on the current challenges in the field and suggestions for future researchProtein Interactions will serve as a fundamental resource for novice researchers who want a systematic introduction to interactomics, as well as for experienced cell biologists and bioinformaticians who want to gain an edge in this exciting new field.

Produktinformation

Utgivningsdatum2022-12-28
Mått170 x 244 x 27 mm
Vikt1 021 g
FormatInbunden
SpråkEngelska
Antal sidor432
FörlagWiley-VCH Verlag GmbH
ISBN9783527348640

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Biologi inom Naturvetenskap och teknik

Volkhard Helms is Professor for Bioinformatics at Saarland University, Germany. He holds a Ph.D. from EMBL Heidelberg and has authored over 200 scientific publications. In 2000 he was named an EMBO Young Investigator. Olga Kalinina is Professor for Drug Bioinformatics at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)/Helmholtz Centre for Infection Research (HZI) and Saarland University, Germany. She holds a Ph.D. from the Engelhardt Institute for Molecular Biology of the Russian Academy of Sciences, and has authored over 50 scientific publications.

Proteins: structure and conformational dynamicsProtein binding interfacesStructures, composition, and modelling of protein complexesKinetics and energetics of protein-protein encounterMarkov-state models for protein-protein encounterCorrelated, co-evolving mutations at PP interfacesProtein-protein-dockingPredicting interacting proteins by deep learningInteractions of membrane proteinsMass spectrometry to detect stoichiometries of protein complexesData resources on protein interactomicsData integration to resolve composition of very large protein complexesCellular protein complexeomesInteractions of transcription factors with DNAInteractions of chromatin remodeling proteins and epigenetic reader/writer proteins with DNAInteractions of proteins with mRNAInteractions of proteins with biological membranesInteractions of proteins with small moleculesSmall molecule inhibitors of protein interactionsBinding pockets on protein surfacesEffects of protein mutations on their interactionsEffects of alternative splicing on protein interactionsEffects of post-translational modifications on protein interactionsSummary and outlook