Protein Interactions

Volkhard Helms is Professor for Bioinformatics at Saarland University, Germany. He holds a Ph.D. from EMBL Heidelberg and has authored over 200 scientific publications. In 2000 he was named an EMBO Young Investigator. Olga Kalinina is Professor for Drug Bioinformatics at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)/Helmholtz Centre for Infection Research (HZI) and Saarland University, Germany. She holds a Ph.D. from the Engelhardt Institute for Molecular Biology of the Russian Academy of Sciences, and has authored over 50 scientific publications.

• Proteins: structure and conformational dynamicsProtein binding interfacesStructures, composition, and modelling of protein complexesKinetics and energetics of protein-protein encounterMarkov-state models for protein-protein encounterCorrelated, co-evolving mutations at PP interfacesProtein-protein-dockingPredicting interacting proteins by deep learningInteractions of membrane proteinsMass spectrometry to detect stoichiometries of protein complexesData resources on protein interactomicsData integration to resolve composition of very large protein complexesCellular protein complexeomesInteractions of transcription factors with DNAInteractions of chromatin remodeling proteins and epigenetic reader/writer proteins with DNAInteractions of proteins with mRNAInteractions of proteins with biological membranesInteractions of proteins with small moleculesSmall molecule inhibitors of protein interactionsBinding pockets on protein surfacesEffects of protein mutations on their interactionsEffects of alternative splicing on protein interactionsEffects of post-translational modifications on protein interactionsSummary and outlook