Del i serien Foundations and Frontiers in Enzymology

Protein Dynamics

Nyhet

Experimental and Computational Approaches

Häftad, Engelska, 2026

AvAna-Nicoleta Bondar,Durba Sengupta

2 239 kr

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Protein Dynamics: Experimental and Computational Approaches investigates protein biology from a biophysical standpoint. The book covers a wide range of topics, including functional protein dynamics, intrinsically disordered proteins, protein folding, misfolding and aggregation, and membrane protein-protein communication. Protein allosteric conformational changes caused by drug binding and disease-associated mutations are also featured, alongside protein dynamics in the context of computer-based drug design. Biophysical techniques for investigating protein structure-dynamics-function relationships across these topics are explored, considering the latest experimental and computational approaches in the field. This book is an ideal reference for researchers in working in biophysics, biochemistry, and related areas.

Covers a broad range of biophysical techniques to study protein dynamics
Investigates an array of different proteins, including receptors, transporters and enzymes
Considers future directions in the field
Features explanation of key concepts and end-of-chapter questions to aid understanding

Produktinformation

Utgivningsdatum2026-06-29
Mått191 x 235 x 29 mm
Vikt450 g
FormatHäftad
SpråkEngelska
SerieFoundations and Frontiers in Enzymology
Antal sidor548
FörlagElsevier Science
ISBN9780443300424

Tillhör följande kategorier

Tillämpad fysik inom Naturvetenskap och teknik
Biokemi inom Naturvetenskap och teknik

Ana-Nicoleta Bondar is a full professor of physics at the Faculty of Physics, University of Bucharest, Romania, and currently a visiting professor at the Forschungszentrum Jülich, Institute for Computational Biomedicine, Germany. Prior to this, she led the theoretical molecular biophysics group at the Freie Universität Berlin, Department of Physics. Dr. Bondar’s research is focused on methodological developments and applications for membrane proteins. Durba Sengupta is Principle Scientist and Assistant Professor at the Physical Chemistry DivisionCSIR-National Chemical Laboratory, Pune, India. The main objective of Dr Sengupta’s research group is to understand self organisation and self-assembly in complex bio-systems, using the tools of physical chemistry. The current focus of her research is membrane biology and understanding the structure, dynamics and functions of proteins, lipids, sugars and sterols within the membrane.

1. Introduction2. Functional protein dynamics3. Protein-protein communication in membrane protein organization and cell signaling4. Intrinsically disordered proteins5. Role of entropy in protein folding6. Functional water molecules and role of ions in protein function7. Computing transition states in enzyme reactions8. G Protein Receptor Signaling9. Protonation-coupled protein dynamics studied with graph algorithms10. Membrane transporters11. Lipids and lipid-protein dynamics in membrane protein function12. Protein misfolding and aggregation13. Proteins of extremophiles14. Protein allosteric conformational changes caused by drug binding and disease-associated mutations15. Computer-based drug design16. Amyloid precursor protein in Alzheimer’s disease