Protein Design and Structure

Rossen Donev received his PhD degree in 1999 from the Institute of Molecular Biology, Bulgarian Academy of Sciences. He did postdoctoral training at Imperial Cancer Research Fund, UK (renamed after the merger with Cancer Research Campaign to Cancer Research UK, London Research Institute) and Cardiff University. In 2007 he was awarded a New Investigator Grant Award from the Medical Research Council (UK) to establish himself as an independent Principle Investigator. In 2010 Dr. Donev was appointed Senior Lecturer at Swansea University. In 2016 Dr. Donev joined MicroPharm Ltd (UK) where currently he is Head of Research. He has published more than 60 research papers, chaired scientific meetings and given invited plenary talks. Rossen Donev has consulted on projects related to development of treatments for neurodevelopmental disorders and cancer therapies. He serves as Editor-in-Chief of the Advances in Protein Chemistry and Structural Biology and on editorial board of several other journals. His research interests include signaling pathways involved in neuropsychiatric disorders and tumor escape from the immune system, and development of therapeutic strategies for their treatment. More recently he has focused on development of immunotherapeutics for non-systemic applications.

• 1. Algorithms for protein designSekhar Talluri2. Computational prediction of protein functional sites—Applications in biotechnology and biomedicineFlorencio Pazos3. Structure and chemistry of enzymatic active sites that play a role in the switch and conformation mechanism Chandrabose Selvaraj, Ondipilliraja Rudhra, Abdulaziz S. Alothaim, Mustfa Alkhanani, and Sanjeev Kumar Singh4. Accelerating therapeutic protein designMohammad ElGamacy5. Aromatic interactions directing peptide nano-assembly Sajitha Sasidharan and Vibin Ramakrishnan6. Understanding binding affinity and specificity of modular protein domains: A focus in ligand design for the polyproline-binding families Jose C. Martinez, Francisco Castillo, Javier Ruiz-Sanz, Javier Murciano-Calles, Ana Camara-Artigas, and Irene Luque7. The structural basis of histone modifying enzyme specificity and promiscuity: Implications for metabolic regulation and drug design Tim J. Kamerzell, Brittney Mikell, Lei Chen, Harold Elias, Buddhadeb Dawn, Calum MacRae, and C. Russell Middaugh8. Designing synthetic transcription factors: A structural perspective Aparna Boral, Madhurima Khamaru, and Devrani Mitra9. Recent advances in structural studies of 14-3-3 protein complexes Nikolai N. Sluchanko10. Immunosafe(r)-by-design nanoparticles: Molecular targets and cell signaling pathways in a next-generation model proxy for humans Annalisa Pinsino and Maria Di Bernardo11. Mutations in G6PC2 gene with increased risk for development of type 2 diabetes: Understanding via computational approach S. Udhaya Kumar, Balu Kamaraj, Rinku Polachirakkal Varghese, V. Anu Preethi, R. Bithia, and C. George Priya Doss12. Computational structural assessment of BReast CAncer type 1 susceptibility protein (BRCA1) and BRCA1-Associated Ring Domain protein 1 (BARD1) mutations on the protein-protein interface D. Thirumal Kumar, S. Udhaya Kumar, Nikita Jain, Baviri Sowmya, Kamakshi Balsekar, R. Siva, Balu Kamaraj, Mariem Sidenna, C. George Priya Doss, and Hatem Zayed13. Evolutionary aspect of Miltefosine transporter proteins in Leishmania major Ritika Kabra and Shailza Singh