Akademibokhandeln
Roberta Lattanzi, Rossella Miele - Prokineticins, Häftad

Häftad, Engelska, 2027

Del i serien Molecular Mediators in Health and Disease: How Cells Communicate

Prokineticins

From the Gastrointestinal Tract to Neuroinflammation

Av Roberta Lattanzi, Rossella Miele

2939 kr

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Beskrivning
Prokineticins: From the Gastrointestinal Tract to Neuroinflammation explores the intricate biology and pathophysiological roles of prokineticin peptides, from developmental processes in the heart and brain to the regulation of homeostasis in health and disease. Beginning with an introduction to prokineticins, the book moves on to discuss physiological functions across the human body, including the regulation of circadian rhythm, food intake, heart and kidney function and the reproductive system. Chapters then cover the prokineticin system in neurogenesis dysfunction, obesity and diabetes, reproductive system disorders and cardiovascular diseases.

The prokinetcin system is also explored in the context of neurodegenerative disease and traumatic brain injury, pain, inflammation, infection and cancer. It also investigates natural and pharmacological inhibitors of PK receptors and closes with a look towards future research perspectives.

  • Explores the diverse physiological roles of prokineticins in neurogenesis, circadian rhythm, reproduction, and cardiovascular function
  • Investigates the pathophysiological implications of altered prokineticin expression in diseases, including cancer, diabetes, and neurodegenerative disorders
  • Highlights the therapeutic potential of prokineticin receptors as targets for treating cardiovascular, metabolic, and nervous system conditions
  • Provides comprehensive analyses of endogenous peptides, synthetic ligands, and modulators of prokineticin receptors in preclinical models
  • Serves as an essential resource for biologists, clinicians, and students, bridging gaps in understanding PKs across various fields
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Roberta Lattanzi is an Associate Professor at the Department of Physiology and Pharmacology, Sapienza University of Rome, Italy. Her research focuses on investigating the functional role of neuropeptides in various biological activities.For several years she has contributed to studies on dermorphins and deltorphins, two important classes of opioid peptides, using receptor binding techniques and in vitro and in vivo pharmacological activity assays. More recently, she has been involved in the identification of a new system of proteins (Bv8/prokineticins) and their receptors and contributed to the study of the diverse physiological and pathological activities in which this system is involved. In particular, she has been dedicated to elucidating the molecular and cellular mechanisms underlying prokineticin-induced nociceptive sensitization and to studying the involvement of the prokineticin system in inflammation/neuroinflammation. She has published over 100 publications with more than 2400 citations.Rossella Miele’s is a researcher at the Department of Biochemical Science at University of Rome, Italy. Her research has always focused on investigating the structure-function of protein and analysis of mechanisms of protein expression using multiple approaches, including molecular biology, biochemistry and genetics using techniques in vitro and in vivo. She has published over 50 publications with more than 1400 citations.

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