Roberta Lattanzi is an Associate Professor at the Department of Physiology and Pharmacology, Sapienza University of Rome, Italy. Her research focuses on investigating the functional role of neuropeptides in various biological activities.For several years she has contributed to studies on dermorphins and deltorphins, two important classes of opioid peptides, using receptor binding techniques and in vitro and in vivo pharmacological activity assays. More recently, she has been involved in the identification of a new system of proteins (Bv8/prokineticins) and their receptors and contributed to the study of the diverse physiological and pathological activities in which this system is involved. In particular, she has been dedicated to elucidating the molecular and cellular mechanisms underlying prokineticin-induced nociceptive sensitization and to studying the involvement of the prokineticin system in inflammation/neuroinflammation. She has published over 100 publications with more than 2400 citations.Rossella Miele’s is a researcher at the Department of Biochemical Science at University of Rome, Italy. Her research has always focused on investigating the structure-function of protein and analysis of mechanisms of protein expression using multiple approaches, including molecular biology, biochemistry and genetics using techniques in vitro and in vivo. She has published over 50 publications with more than 1400 citations.

• Part I. Introduction1 Prokineticin phylogenesis: from early studies in frogs to mammals2. Prokineticins: structure, distribution and regulation3. Prokineticin receptors: structure, distribution and regulation4. Prokineticin system: signal transductionPart II. Relation structure-function5. Prokineticins and splice isoforms6. Prokineticin receptors and splicing isoforms7. Structural elements underlying prokineticin-receptor interactions8. Interaction of prokineticin receptors with accessory proteinsPart III. Physiological functions of the prokineticin system9. Neurogenesis10. Regulation of circadian rhythm11. Regulation of food intake and energy balance12. Regulation of the development and function of reproductive system.13. Regulation of the development and function of heart14. Regulation of the development and function of kidneyPart IV. The prokineticin system in neurogenesis disfunctions15. The prokineticin system in Kallmann syndrome16. The prokineticin system in Hirschprung disease17. The prokineticin system in mood disorders and stressPart V. The prokineticin system in obesity and diabetes18. Central regulation of obesity through prokineticin signalling19. Regulation of visceral adipose tissue growth by prokineticin signalling20. The role of the prokineticin system in metabolic syndrome21. The role of the prokineticin system in insulin resistance22. The role of the prokineticin system in diabetes-mediated cardiomyopathy and diabetes-mediated skeletal muscle dysfunction23. The role of prokineticin 2 in torpor and temperature regulationPart VI. The prokineticin system in disorders of the reproductive system functions24. The role of the prokineticin system in female infertility: gestational hypertension and pre-eclampsia25. The role of the prokineticin system in male infertility: Klinefelter syndromePart VII. The prokineticin system in cardiovascular diseases26. The role of the prokineticin system in cardiovascular diseases: myocardial infarction-induced heart failure27. The role of the prokineticin system in the development of pathological hypertrophic cardiomyopathyPart VIII. The prokineticin system in neurodegenerative disease and in neuronal injury28. Alzheimer's disease29. Parkinson’s disease30. Traumatic brain injuryPart IX. The prokineticin system in pain31. Nociceptive pain32. Inflammatory pain33. Neuropathic pain34. Pleasant touchPart X. The prokineticin system in autoimmunity, inflammation and infection35. General inflammation36. Multiple Sclerosis37. Arthritis and Osteoarthritis38. Gastro-intestinal inflammatory diseases39. Covid40. Chagas DiseasePart XI. The prokineticin system in cancer-related inflammation41. Prokineticins and cancer progression42. Prokineticins in different types of cancer43. Prokineticins as biomarkersPart XII. Natural and pharmacological inhibitors of PK receptors44. Non peptide antagonists of the prokineticin receptors45. Peptide antagonists of the prokineticin receptorsPart XIII - Conclusion46. Future directions for PK research

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Roberta Lattanzi is an Associate Professor at the Department of Physiology and Pharmacology, Sapienza University of Rome, Italy. Her research focuses on investigating the functional role of neuropeptides in various biological activities.For several years she has contributed to studies on dermorphins and deltorphins, two important classes of opioid peptides, using receptor binding techniques and in vitro and in vivo pharmacological activity assays. More recently, she has been involved in the identification of a new system of proteins (Bv8/prokineticins) and their receptors and contributed to the study of the diverse physiological and pathological activities in which this system is involved. In particular, she has been dedicated to elucidating the molecular and cellular mechanisms underlying prokineticin-induced nociceptive sensitization and to studying the involvement of the prokineticin system in inflammation/neuroinflammation. She has published over 100 publications with more than 2400 citations.Rossella Miele’s is a researcher at the Department of Biochemical Science at University of Rome, Italy. Her research has always focused on investigating the structure-function of protein and analysis of mechanisms of protein expression using multiple approaches, including molecular biology, biochemistry and genetics using techniques in vitro and in vivo. She has published over 50 publications with more than 1400 citations.

• Part I. Introduction1 Prokineticin phylogenesis: from early studies in frogs to mammals2. Prokineticins: structure, distribution and regulation3. Prokineticin receptors: structure, distribution and regulation4. Prokineticin system: signal transductionPart II. Relation structure-function5. Prokineticins and splice isoforms6. Prokineticin receptors and splicing isoforms7. Structural elements underlying prokineticin-receptor interactions8. Interaction of prokineticin receptors with accessory proteinsPart III. Physiological functions of the prokineticin system9. Neurogenesis10. Regulation of circadian rhythm11. Regulation of food intake and energy balance12. Regulation of the development and function of reproductive system.13. Regulation of the development and function of heart14. Regulation of the development and function of kidneyPart IV. The prokineticin system in neurogenesis disfunctions15. The prokineticin system in Kallmann syndrome16. The prokineticin system in Hirschprung disease17. The prokineticin system in mood disorders and stressPart V. The prokineticin system in obesity and diabetes18. Central regulation of obesity through prokineticin signalling19. Regulation of visceral adipose tissue growth by prokineticin signalling20. The role of the prokineticin system in metabolic syndrome21. The role of the prokineticin system in insulin resistance22. The role of the prokineticin system in diabetes-mediated cardiomyopathy and diabetes-mediated skeletal muscle dysfunction23. The role of prokineticin 2 in torpor and temperature regulationPart VI. The prokineticin system in disorders of the reproductive system functions24. The role of the prokineticin system in female infertility: gestational hypertension and pre-eclampsia25. The role of the prokineticin system in male infertility: Klinefelter syndromePart VII. The prokineticin system in cardiovascular diseases26. The role of the prokineticin system in cardiovascular diseases: myocardial infarction-induced heart failure27. The role of the prokineticin system in the development of pathological hypertrophic cardiomyopathyPart VIII. The prokineticin system in neurodegenerative disease and in neuronal injury28. Alzheimer's disease29. Parkinson’s disease30. Traumatic brain injuryPart IX. The prokineticin system in pain31. Nociceptive pain32. Inflammatory pain33. Neuropathic pain34. Pleasant touchPart X. The prokineticin system in autoimmunity, inflammation and infection35. General inflammation36. Multiple Sclerosis37. Arthritis and Osteoarthritis38. Gastro-intestinal inflammatory diseases39. Covid40. Chagas DiseasePart XI. The prokineticin system in cancer-related inflammation41. Prokineticins and cancer progression42. Prokineticins in different types of cancer43. Prokineticins as biomarkersPart XII. Natural and pharmacological inhibitors of PK receptors44. Non peptide antagonists of the prokineticin receptors45. Peptide antagonists of the prokineticin receptorsPart XIII - Conclusion46. Future directions for PK research

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Roberta Lattanzi is an Associate Professor at the Department of Physiology and Pharmacology, Sapienza University of Rome, Italy. Her research focuses on investigating the functional role of neuropeptides in various biological activities.For several years she has contributed to studies on dermorphins and deltorphins, two important classes of opioid peptides, using receptor binding techniques and in vitro and in vivo pharmacological activity assays. More recently, she has been involved in the identification of a new system of proteins (Bv8/prokineticins) and their receptors and contributed to the study of the diverse physiological and pathological activities in which this system is involved. In particular, she has been dedicated to elucidating the molecular and cellular mechanisms underlying prokineticin-induced nociceptive sensitization and to studying the involvement of the prokineticin system in inflammation/neuroinflammation. She has published over 100 publications with more than 2400 citations.Rossella Miele’s is a researcher at the Department of Biochemical Science at University of Rome, Italy. Her research has always focused on investigating the structure-function of protein and analysis of mechanisms of protein expression using multiple approaches, including molecular biology, biochemistry and genetics using techniques in vitro and in vivo. She has published over 50 publications with more than 1400 citations.

• Part I. Introduction1 Prokineticin phylogenesis: from early studies in frogs to mammals2. Prokineticins: structure, distribution and regulation3. Prokineticin receptors: structure, distribution and regulation4. Prokineticin system: signal transductionPart II. Relation structure-function5. Prokineticins and splice isoforms6. Prokineticin receptors and splicing isoforms7. Structural elements underlying prokineticin-receptor interactions8. Interaction of prokineticin receptors with accessory proteinsPart III. Physiological functions of the prokineticin system9. Neurogenesis10. Regulation of circadian rhythm11. Regulation of food intake and energy balance12. Regulation of the development and function of reproductive system.13. Regulation of the development and function of heart14. Regulation of the development and function of kidneyPart IV. The prokineticin system in neurogenesis disfunctions15. The prokineticin system in Kallmann syndrome16. The prokineticin system in Hirschprung disease17. The prokineticin system in mood disorders and stressPart V. The prokineticin system in obesity and diabetes18. Central regulation of obesity through prokineticin signalling19. Regulation of visceral adipose tissue growth by prokineticin signalling20. The role of the prokineticin system in metabolic syndrome21. The role of the prokineticin system in insulin resistance22. The role of the prokineticin system in diabetes-mediated cardiomyopathy and diabetes-mediated skeletal muscle dysfunction23. The role of prokineticin 2 in torpor and temperature regulationPart VI. The prokineticin system in disorders of the reproductive system functions24. The role of the prokineticin system in female infertility: gestational hypertension and pre-eclampsia25. The role of the prokineticin system in male infertility: Klinefelter syndromePart VII. The prokineticin system in cardiovascular diseases26. The role of the prokineticin system in cardiovascular diseases: myocardial infarction-induced heart failure27. The role of the prokineticin system in the development of pathological hypertrophic cardiomyopathyPart VIII. The prokineticin system in neurodegenerative disease and in neuronal injury28. Alzheimer's disease29. Parkinson’s disease30. Traumatic brain injuryPart IX. The prokineticin system in pain31. Nociceptive pain32. Inflammatory pain33. Neuropathic pain34. Pleasant touchPart X. The prokineticin system in autoimmunity, inflammation and infection35. General inflammation36. Multiple Sclerosis37. Arthritis and Osteoarthritis38. Gastro-intestinal inflammatory diseases39. Covid40. Chagas DiseasePart XI. The prokineticin system in cancer-related inflammation41. Prokineticins and cancer progression42. Prokineticins in different types of cancer43. Prokineticins as biomarkersPart XII. Natural and pharmacological inhibitors of PK receptors44. Non peptide antagonists of the prokineticin receptors45. Peptide antagonists of the prokineticin receptorsPart XIII - Conclusion46. Future directions for PK research

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