This book constitutes the refereed proceedings of the 19th IFIP WG 5.1 International Conference, PLM 2022, Grenoble, France, July 10–13, 2022, Revised Selected Papers.The 67 full papers included in this book were carefully reviewed and selected from 94 submissions. They were organized in topical sections as follows: Organisation: Knowledge Management, Business Models, Sustainability, End-to-End PLM, Modelling tools: Model-Based Systems Engineering, Geometric modelling, Maturity models, Digital Chain Process, Transversal Tools: Artificial Intelligence, Advanced Visualization and Interaction, Machine learning, Product development: Design Methods, Building Design, Smart Products, New Product Development, Manufacturing: Sustainable Manufacturing, Lean Manufacturing, Models for Manufacturing.