This book constitutes the refereed proceedings of the 25th International Conference on Product-Focused Software Process Improvement, PROFES 2024, held in Tartu, Estonia, during December 2–4, 2024.The 9 Industry papers, 2 Workshop papers, 2 Doctoral symposium papers and 1 Keynote paper presented in this volume were carefully reviewed and selected from 85 submissions. The contributions were organized in topical sections as follows: Industry Papers; Third Workshop on Engineering Processes and Practices for Quantum Software (PPQS 2024); and Doctoral Symposium Papers.