Chuei-Tin Chang received his BS degree in Chemical Engineering from National Taiwan University and his PhD in Chemical Engineering from Columbia University in 1976 and 1982, respectively. He worked as a process engineer for FMC Corporation (Princeton, New Jersey) from 1982 to 1985 and as an assistant professor at the Department of Chemical Engineering at the University of Nebraska (Lincoln) from 1985 to 1989. He later joined the faculty of Chemical Engineering Department of the National Cheng Kung University (Tainan, Taiwan) in 1989, became a full professor in 1993, and also received the Distinguished Professor Award (2008-2011). He was a visiting research scholar at Northwestern University (1992), Leihigh University (1998), and Georgia Institute of Technology (2006). He is a senior member of AIChE and TwIChE. His current research interests are mainly concerned with process systems engineering (PSE), which include process integration, process safety assessment and faultdiagnosis, etc. He is the author of 1 monograph, 114 peer-reviewed papers and 98 conference papers.Hao-Yeh Lee is a professor in Department of Chemical Engineering at National Taiwan University of Science & Technology (Taiwan Tech.)(Taipei, Taiwan). He received his BS and MS degrees in Chemical and Materials Engineering of the Chang Gung University in 1998 and 2000. In 2007, he completed his Ph.D degree and was a Postdoctoral Fellow in the Institute of Chemical Engineering at National Taiwan University (NTU). He is the lecturer of Consortium of Reaction/Separation Processes in the Petrochemical Research Center of National Taiwan University since 2006. He worked with Advanced Control & Systems Inc. (Taipei, Taiwan) before joining Taiwan Tech. in 2010. From 2011 to 2020, He was an assistant and associate professor in Chemical Engineering Department of Taiwan Tech.. Later, He became a full professor in 2020. His research interests include process design, control, optimization and energy integration, etc., especially in the azeotropic and reactive distillation processes. He is the author of 4 book chapters, 45 published papers and 41 conference papers.Vincentius Surya Kurnia Adi is an assistant professor in the Chemical Engineering Department, National Chung Hsing University. He received his BS in Chemical Engineering from Institut Teknologi Bandung, Indonesia, in 2005. He worked as a process engineer for PT. Arianto Darmawan until 2006, and later in 2008 received his MS in Chemical Engineering from National Cheng Kung University, Tainan, Taiwan. He finished his PhD in Chemical Engineering from National Cheng Kung University, Tainan, Taiwan, in 2013. Later on, he worked as a postdoctoral researcher in the same institution until 2015. Afterwards, he moved to Chemical Engineering Department, Imperial College London as research associate before he joined as one of the faculty members in the Chemical Engineering Department, NationalChung Hsing University in 2016. His research centers on developing new insights in process synthesis and design, especially in flexibility analysis of chemical processes.

• Introduction.- Chapter 1. Heuristic Approach to Procedure Synthesis.- Chapter 2. Model-Based Approach to Procedure Synthesis.- Chapter 3. Normal Operating Procedures Based on Dynamic Simulations.- Chapter 4. Normal Operating Procedures with Petri Nets.- Chapter 5. Normal Operating Procedures with Automata.- Chapter 6. Abnormal Situation Management via Dynamic Simulations.- Chapter 7. Abnormal Situation Management Based on Petri Nets.- Chapter 8. Abnormal Situation Management Based on Automata.- Chapter 9. Abnormal Situation Management Based on Hybrid Models.- Chapter 10. Future Works.

Chuei-Tin Chang received his BS degree in Chemical Engineering from National Taiwan University and his PhD in Chemical Engineering from Columbia University in 1976 and 1982, respectively. He worked as a process engineer for FMC Corporation (Princeton, New Jersey) from 1982 to 1985 and as an assistant professor at the Department of Chemical Engineering at the University of Nebraska (Lincoln) from 1985 to 1989. He later joined the faculty of Chemical Engineering Department of the National Cheng Kung University (Tainan, Taiwan) in 1989, became a full professor in 1993, and also received the Distinguished Professor Award (2008-2011). He was a visiting research scholar at Northwestern University (1992), Leihigh University (1998), and Georgia Institute of Technology (2006). He is a senior member of AIChE and TwIChE. His current research interests are mainly concerned with process systems engineering (PSE), which include process integration, process safety assessment and faultdiagnosis, etc. He is the author of 1 monograph, 114 peer-reviewed papers and 98 conference papers.Hao-Yeh Lee is a professor in Department of Chemical Engineering at National Taiwan University of Science & Technology (Taiwan Tech.)(Taipei, Taiwan). He received his BS and MS degrees in Chemical and Materials Engineering of the Chang Gung University in 1998 and 2000. In 2007, he completed his Ph.D degree and was a Postdoctoral Fellow in the Institute of Chemical Engineering at National Taiwan University (NTU). He is the lecturer of Consortium of Reaction/Separation Processes in the Petrochemical Research Center of National Taiwan University since 2006. He worked with Advanced Control & Systems Inc. (Taipei, Taiwan) before joining Taiwan Tech. in 2010. From 2011 to 2020, He was an assistant and associate professor in Chemical Engineering Department of Taiwan Tech.. Later, He became a full professor in 2020. His research interests include process design, control, optimization and energy integration, etc., especially in the azeotropic and reactive distillation processes. He is the author of 4 book chapters, 45 published papers and 41 conference papers.Vincentius Surya Kurnia Adi is an assistant professor in the Chemical Engineering Department, National Chung Hsing University. He received his BS in Chemical Engineering from Institut Teknologi Bandung, Indonesia, in 2005. He worked as a process engineer for PT. Arianto Darmawan until 2006, and later in 2008 received his MS in Chemical Engineering from National Cheng Kung University, Tainan, Taiwan. He finished his PhD in Chemical Engineering from National Cheng Kung University, Tainan, Taiwan, in 2013. Later on, he worked as a postdoctoral researcher in the same institution until 2015. Afterwards, he moved to Chemical Engineering Department, Imperial College London as research associate before he joined as one of the faculty members in the Chemical Engineering Department, NationalChung Hsing University in 2016. His research centers on developing new insights in process synthesis and design, especially in flexibility analysis of chemical processes.

• Introduction.- Chapter 1. Heuristic Approach to Procedure Synthesis.- Chapter 2. Model-Based Approach to Procedure Synthesis.- Chapter 3. Normal Operating Procedures Based on Dynamic Simulations.- Chapter 4. Normal Operating Procedures with Petri Nets.- Chapter 5. Normal Operating Procedures with Automata.- Chapter 6. Abnormal Situation Management via Dynamic Simulations.- Chapter 7. Abnormal Situation Management Based on Petri Nets.- Chapter 8. Abnormal Situation Management Based on Automata.- Chapter 9. Abnormal Situation Management Based on Hybrid Models.- Chapter 10. Future Works.

Chuei-Tin Chang received his BS degree in Chemical Engineering from National Taiwan University and his PhD in Chemical Engineering from Columbia University in 1976 and 1982, respectively. He worked as a process engineer for FMC Corporation (Princeton, New Jersey) from 1982 to 1985 and as an assistant professor at the Department of Chemical Engineering at the University of Nebraska (Lincoln) from 1985 to 1989. He later joined the faculty of Chemical Engineering Department of the National Cheng Kung University (Tainan, Taiwan) in 1989, became a full professor in 1993, and also received the Distinguished Professor Award (2008-2011). He was a visiting research scholar at Northwestern University (1992), Leihigh University (1998), and Georgia Institute of Technology (2006). He is a senior member of AIChE and TwIChE. His current research interests are mainly concerned with process systems engineering (PSE), which include process integration, process safety assessment and faultdiagnosis, etc. He is the author of 1 monograph, 114 peer-reviewed papers and 98 conference papers.Hao-Yeh Lee is a professor in Department of Chemical Engineering at National Taiwan University of Science & Technology (Taiwan Tech.)(Taipei, Taiwan). He received his BS and MS degrees in Chemical and Materials Engineering of the Chang Gung University in 1998 and 2000. In 2007, he completed his Ph.D degree and was a Postdoctoral Fellow in the Institute of Chemical Engineering at National Taiwan University (NTU). He is the lecturer of Consortium of Reaction/Separation Processes in the Petrochemical Research Center of National Taiwan University since 2006. He worked with Advanced Control & Systems Inc. (Taipei, Taiwan) before joining Taiwan Tech. in 2010. From 2011 to 2020, He was an assistant and associate professor in Chemical Engineering Department of Taiwan Tech.. Later, He became a full professor in 2020. His research interests include process design, control, optimization and energy integration, etc., especially in the azeotropic and reactive distillation processes. He is the author of 4 book chapters, 45 published papers and 41 conference papers.Vincentius Surya Kurnia Adi is an assistant professor in the Chemical Engineering Department, National Chung Hsing University. He received his BS in Chemical Engineering from Institut Teknologi Bandung, Indonesia, in 2005. He worked as a process engineer for PT. Arianto Darmawan until 2006, and later in 2008 received his MS in Chemical Engineering from National Cheng Kung University, Tainan, Taiwan. He finished his PhD in Chemical Engineering from National Cheng Kung University, Tainan, Taiwan, in 2013. Later on, he worked as a postdoctoral researcher in the same institution until 2015. Afterwards, he moved to Chemical Engineering Department, Imperial College London as research associate before he joined as one of the faculty members in the Chemical Engineering Department, NationalChung Hsing University in 2016. His research centers on developing new insights in process synthesis and design, especially in flexibility analysis of chemical processes.

• Introduction.- Chapter 1. Heuristic Approach to Procedure Synthesis.- Chapter 2. Model-Based Approach to Procedure Synthesis.- Chapter 3. Normal Operating Procedures Based on Dynamic Simulations.- Chapter 4. Normal Operating Procedures with Petri Nets.- Chapter 5. Normal Operating Procedures with Automata.- Chapter 6. Abnormal Situation Management via Dynamic Simulations.- Chapter 7. Abnormal Situation Management Based on Petri Nets.- Chapter 8. Abnormal Situation Management Based on Automata.- Chapter 9. Abnormal Situation Management Based on Hybrid Models.- Chapter 10. Future Works.