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The Fine Chemicals industry is concerned with the manufacture of relatively small volume products by multistage manufacturing processes. Pharmaceuticals, agrochemicals, colouring materials and biocidal compounds are typical examples. Understanding the fundamental science behind these chemical processes is of great benefit in the development of efficient, high-yielding and environmentally friendly processes. However, there are no other texts which specifically address this topic by covering the physiochemical principles underpinning the subject. This primer outlines the strategy for obtaining the requisite data, and then goes on to outline the chemical and chemical engineering concepts involved in process development. These include a description of pre-reaction equilibria in single and two-phase systems, factors influencing selectivity in competing reactions, mixing effects in single and two-phase reactions, the science behind workup processes, and a discussion of the principles behind scale-up.
Dr John Atherton, Process Studies Group, Zeneca Huddersfield Works, Professor Keith Carpenter, Process Studies Group, Zeneca Huddersfield Works,
1. The scope of process development ; 2. Strategy for process development ; 3. Pre-reaction equilibria ; 4. Competing reactions in homogeneous media ; 5. Mixing effects in pseudo-homgeneous systems ; 6. Equilibria in multiphase systems ; 7. Dispersion and mass transfer in multiphase systems ; 8. Mass-transfer and reaction in two-phase systems ; 9. Product isolation and workup ; 10. Scale-up ; Index
"This book [makes] invaluable reading for undergraduates with a basic knowledge of physical organic chemistry and algebra. I recommend it." James Betts in Education in Chemistry, May 2001
John Saunders, California) Saunders, John (Vice President of Chemistry, Neurocrine Biosciences, San Diego, California, Vice President of Chemistry, Neurocrine Biosciences, San Diego
Martin Grossel, Oxford) Grossel, Martin (Senior Lecturer in Chemistry, University of Southampton; and Lecturer and Ordinary Student in Organic Chemistry, Senior Lecturer in Chemistry, University of Southampton; and Lecturer and Ordinary Student in Organic Chemistry, Christ Church
Jeremy Robertson, Oxford) Robertson, Jeremy (University Lecturer in Organic Chemistry and Fellow, University Lecturer in Organic Chemistry and Fellow, Brasenose College