From the reviews: "The editors of this handbook ... have 'collect(ed) together, in one place, the algorithms and methods that form the modern bioinformatician's toolkit.' ... Each chapter contains an introduction to the respective topic, detailed descriptions of the relevant algorithmic methods, software implementations, and applications, and concludes with advanced topics. ... this handbook provides some value for researchers and practitioners in the field. ... In summary, for most of the topics covered, this book complements the standard textbooks in a useful way." (Gunnar Klau, ACM Computing Reviews, June, 2011)