Prions and Mad Cow Disease

Inbunden, Engelska, 2003

Av Brian K. Nunnally, Ira S. Krull, USA) Nunnally, Brian K. (Wyeth Vaccines, Sanford, North Carolina, USA) Krull, Ira S. (Northeastern University, Boston, Massachusetts

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The alarm sounded by Canada's recently confirmed case of bovine spongiform encephalopathy (BSE) has reaffirmed the exigency of establishing improved safeguards and more aggressive surveillance protocols in North America and around the world. Research converging on the probable causative agent-prion proteins-calls for intensive assessment of the headway gained in tracing prions, testing for transmissible neurodegenerative diseases, and developing methods for cornering the epidemic. Administered by an illustrious panel of 36 international contributors, this timely book marshals techniques for prion protein assay and diagnosis of transmissible spongiform encephalopathies (TSEs).

Produktinformation

Utgivningsdatum2003-10-17
Mått152 x 229 x undefined mm
Vikt718 g
FormatInbunden
SpråkEngelska
Antal sidor452
FörlagTaylor & Francis Inc
ISBN9780824740832

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Foreword, Preface, Contributors, 1. Taking Aim at the Transmissible Spongiform Encephalopathies Infectious Agents, 2. Prions, the Protein Hypothesis, and Scientific Revolutions, 3. A Simulation Model for Evaluating the Potential for Spread of Bovine Spongiform Encephalopathy in Animals or to People, 4. Actions to Prevent Bovine Spongiform Encephalopathy from Entering the United States, 5. Overview of Transmissible Spongiform Encephalopathy in Cervids in the United States, 6. Bioassays for Prions, 7. Cyclic Amplification of Scrapie Prion Protein: Implications for Diagnosis, 8. The Enfer Transmissible Spongiform Encephalopathies Assay: Chemiluminescent ELISA of Prion Proteins, 9. Sensitive Detection of Prion Proteins by Immunoassay: CEA/Bio-Rad Test, 10. The Diagnosis of Transmissible Spongiform Encephalopathies Using Differential Extraction and DELFIA, 11. In Vivo Diagnosis of Prion Diseases, 12. Diagnosis of Prion Diseases by Multispectral Techniques, 13. Detection of the Prion Protein in Blood Using a Fluorescence Immunoassay, 14. Prion Detection and Application to the Safety of Biological Products, Index