Robert Lanza is an American scientist and author whose research spans the range of natural science, from biology to theoretical physics. TIME magazine recognized him as one of the “100 Most Influential People in the World,” and Prospect magazine named him one of the Top 50 “World Thinkers.” He has hundreds of scientific publications and over 30 books, including definitive references in the fields of stem cells, tissue engineering, and regenerative medicine. He’s a former Fulbright Scholar and studied with polio-pioneer Jonas Salk and Nobel laureates Gerald Edelman (known for his work on the biological basis of consciousness) and Rodney Porter. He also worked closely (and co-authored papers in Science on self-awareness and symbolic communication) with noted Harvard psychologist BF Skinner. Dr. Lanza was part of the team that cloned the world’s first human embryo, the first endangered species, and published the first-ever reports of pluripotent stem cell use in humans. Robert Langer received honorary doctorates from the ETH (Switzerland) in 1996 and the Technion (Israel) in 1997. Dr. Langer is the Kenneth J. Germeshausen Professor of Chemical and Biomedical Engineering at MIT. He received a Bachelor’s Degree from Cornell University in 1970 and a Sc.D. from MIT in 1974, both in chemical engineering. Dr. Langer has written 590 articles, 400 abstracts, 350 patents, and has edited 12 books.Dr. Langer has received over 70 major awards, including the Gairdner Foundation International Award, the Lemelson-MIT prize, the American Chemical Society (ACS) Polymer Chemistry and Applied Polymer Science Awards, Creative Polymer Chemistry Award (ACS, Polymer Division), the Pearlman Memorial Lectureship Award (ACD, Biochemical Technology Division), and the A.I.Ch.E’s Walker, Professional Progress, Bioengineering, and Stine Materials Science and Engineering Awards. In 1989, Dr. Langer was elected to the Institute of Medicine and the National Academy of Sciences, and in 1992 he was elected to both the National Academy of Engineering and to the National Academy of Sciences. He is the only active member of all 3 United States National Academies. Dr. Joseph P. Vacanti received his M.D. degree from the university of Nebraska in 1974. He received his training in general surgery at the Massachusetts General Hospital from 1974 through 1981 and in pediatric surgery at The Children’s Hospital, Boston from 1981 through 1983. He then received clinical training in transplantation from the University of Pittsburgh. He spent two years in the laboratories of Dr. M. Judah Folkman working in the filed on angiogenesis from 1977 through 1979. Upon completion of his training, Dr. Vacanti joined the staff in surgery at children’s Hospital in Boston and began clinical programs in pediatric liver transplantation and extracorporeal membrane oxygenation. In the laboratory, he continued studies in and began work in the filed of tissue engineering in 1985. Dr. Vacanti is now John Homans Professor of Surgery at Harvard Medical School, Visiting surgeon at Massachusetts General Hospital, director of the Wellman 6 Surgical laboratories, director of the Laboratory of Tissue Engineering and Organ Fabrication and Director of Pediatric Transplantation at Massachusetts General Hospital, Boston. He has authored more than 120 original reports, 30 book chapters, and 197 abstracts. He has more than 25 patents or patents pending in the United States, Europe, and Japan. Anthony Atala, MD, is the G. Link Professor and Director of the Wake Forest Institute for Regenerative Medicine. Seventeen of his lab’s technologies have been translated to patients, including the first tissue-engineered organ for permanent implantation in a human. His research led to the discovery of a multipotent source of stem cells from amniotic fluid and placenta, advances in 3D printing of tissues and organs, and body-on-a-chip technologies. His work was twice listed among Time Magazine’s top 10 medical breakthroughs of the year, and he is a recipient of the Smithsonian Ingenuity Award. He has published over 900 journal articles, is the editor of 25 books, and holds over 250 national and international patents. Dr. Atala is a member of the National Academy of Medicine, the National Academy of Inventors, and the American Institute for Medical and Biological Engineering.

• PART I – FoundationsChapter 1 – IntroductionBedir Tekinerdogan, Dominique Blouin, Hans Vangheluwe, Miguel Goulão, Paulo Carreira, Vasco AmaralChapter 2An Ontological Foundation for Understanding Multi-Paradigm Modeling for Cyber-Physical Systems R. Paige, M. van den BrandChapter 3Feature-based Survey of Cyber-Physical SystemsB. Akesson, J. Hooman, R. Dekker, W. Ekkelkamp, B. StottelaarPART II - TechniquesChapter 4 Current standards and best practices used in CPSG. Orhan & M. AksitChapter 5Tools and techniques used in different disciplines for CPS development: Modeling languagesS. Schuster, I. Schaefer, C. Seidl Chapter 6Tools and techniques used in different disciplines for CPS development: Interfaces for InteroperabilityO. Al-wadeai, A. García-Domínguez, A. Bagnato, A. Abhervé, K. Barmpis Chapter 7Tools and techniques used in different disciplines for CPS development: ProcessesY. Luo, J. Mengerink, M. van den Brand, R. SchiffelersChapter 8Requirements for future MPM4CPS modelling tools and techniquesB. Tekinerdogan, D. BlouinPART III – Application DomainsChapter 9Case Study: Alarm Detection and Monitoring of Smart Factory Environment using Hybrid Sensor Network L. Banjanovic-Mehmedovic, D. Blouin, F. Mehmedovic, M. ZukicChapter 10 Case Study: Embedded Devices Constantin-Bala Zamfirescu and Peter LarsenChapter 11Case Study: SmartLab Cloud System for IoTH. VangheluweChapter 12Automated Analysis of Model-Driven Artifacts in Industry – Big Data AnalyticsY. Luo, J. Mengerink, M. van den Brand, R. Schiffelers PART IV – EducationChapter 13On a MPM4CPS CurriculaV. Amaral, M. GoulãoChapter 14Developing a mutually-recognized cross-domain study program in cyber-physical systemsPaulo CarreiraGlossary Author IndexSubject Index

Robert Lanza is an American scientist and author whose research spans the range of natural science, from biology to theoretical physics. TIME magazine recognized him as one of the “100 Most Influential People in the World,” and Prospect magazine named him one of the Top 50 “World Thinkers.” He has hundreds of scientific publications and over 30 books, including definitive references in the fields of stem cells, tissue engineering, and regenerative medicine. He’s a former Fulbright Scholar and studied with polio-pioneer Jonas Salk and Nobel laureates Gerald Edelman (known for his work on the biological basis of consciousness) and Rodney Porter. He also worked closely (and co-authored papers in Science on self-awareness and symbolic communication) with noted Harvard psychologist BF Skinner. Dr. Lanza was part of the team that cloned the world’s first human embryo, the first endangered species, and published the first-ever reports of pluripotent stem cell use in humans. Robert Langer received honorary doctorates from the ETH (Switzerland) in 1996 and the Technion (Israel) in 1997. Dr. Langer is the Kenneth J. Germeshausen Professor of Chemical and Biomedical Engineering at MIT. He received a Bachelor’s Degree from Cornell University in 1970 and a Sc.D. from MIT in 1974, both in chemical engineering. Dr. Langer has written 590 articles, 400 abstracts, 350 patents, and has edited 12 books.Dr. Langer has received over 70 major awards, including the Gairdner Foundation International Award, the Lemelson-MIT prize, the American Chemical Society (ACS) Polymer Chemistry and Applied Polymer Science Awards, Creative Polymer Chemistry Award (ACS, Polymer Division), the Pearlman Memorial Lectureship Award (ACD, Biochemical Technology Division), and the A.I.Ch.E’s Walker, Professional Progress, Bioengineering, and Stine Materials Science and Engineering Awards. In 1989, Dr. Langer was elected to the Institute of Medicine and the National Academy of Sciences, and in 1992 he was elected to both the National Academy of Engineering and to the National Academy of Sciences. He is the only active member of all 3 United States National Academies. Dr. Joseph P. Vacanti received his M.D. degree from the university of Nebraska in 1974. He received his training in general surgery at the Massachusetts General Hospital from 1974 through 1981 and in pediatric surgery at The Children’s Hospital, Boston from 1981 through 1983. He then received clinical training in transplantation from the University of Pittsburgh. He spent two years in the laboratories of Dr. M. Judah Folkman working in the filed on angiogenesis from 1977 through 1979. Upon completion of his training, Dr. Vacanti joined the staff in surgery at children’s Hospital in Boston and began clinical programs in pediatric liver transplantation and extracorporeal membrane oxygenation. In the laboratory, he continued studies in and began work in the filed of tissue engineering in 1985. Dr. Vacanti is now John Homans Professor of Surgery at Harvard Medical School, Visiting surgeon at Massachusetts General Hospital, director of the Wellman 6 Surgical laboratories, director of the Laboratory of Tissue Engineering and Organ Fabrication and Director of Pediatric Transplantation at Massachusetts General Hospital, Boston. He has authored more than 120 original reports, 30 book chapters, and 197 abstracts. He has more than 25 patents or patents pending in the United States, Europe, and Japan. Anthony Atala, MD, is the G. Link Professor and Director of the Wake Forest Institute for Regenerative Medicine. Seventeen of his lab’s technologies have been translated to patients, including the first tissue-engineered organ for permanent implantation in a human. His research led to the discovery of a multipotent source of stem cells from amniotic fluid and placenta, advances in 3D printing of tissues and organs, and body-on-a-chip technologies. His work was twice listed among Time Magazine’s top 10 medical breakthroughs of the year, and he is a recipient of the Smithsonian Ingenuity Award. He has published over 900 journal articles, is the editor of 25 books, and holds over 250 national and international patents. Dr. Atala is a member of the National Academy of Medicine, the National Academy of Inventors, and the American Institute for Medical and Biological Engineering.

• PART I – FoundationsChapter 1 – IntroductionBedir Tekinerdogan, Dominique Blouin, Hans Vangheluwe, Miguel Goulão, Paulo Carreira, Vasco AmaralChapter 2An Ontological Foundation for Understanding Multi-Paradigm Modeling for Cyber-Physical Systems R. Paige, M. van den BrandChapter 3Feature-based Survey of Cyber-Physical SystemsB. Akesson, J. Hooman, R. Dekker, W. Ekkelkamp, B. StottelaarPART II - TechniquesChapter 4 Current standards and best practices used in CPSG. Orhan & M. AksitChapter 5Tools and techniques used in different disciplines for CPS development: Modeling languagesS. Schuster, I. Schaefer, C. Seidl Chapter 6Tools and techniques used in different disciplines for CPS development: Interfaces for InteroperabilityO. Al-wadeai, A. García-Domínguez, A. Bagnato, A. Abhervé, K. Barmpis Chapter 7Tools and techniques used in different disciplines for CPS development: ProcessesY. Luo, J. Mengerink, M. van den Brand, R. SchiffelersChapter 8Requirements for future MPM4CPS modelling tools and techniquesB. Tekinerdogan, D. BlouinPART III – Application DomainsChapter 9Case Study: Alarm Detection and Monitoring of Smart Factory Environment using Hybrid Sensor Network L. Banjanovic-Mehmedovic, D. Blouin, F. Mehmedovic, M. ZukicChapter 10 Case Study: Embedded Devices Constantin-Bala Zamfirescu and Peter LarsenChapter 11Case Study: SmartLab Cloud System for IoTH. VangheluweChapter 12Automated Analysis of Model-Driven Artifacts in Industry – Big Data AnalyticsY. Luo, J. Mengerink, M. van den Brand, R. Schiffelers PART IV – EducationChapter 13On a MPM4CPS CurriculaV. Amaral, M. GoulãoChapter 14Developing a mutually-recognized cross-domain study program in cyber-physical systemsPaulo CarreiraGlossary Author IndexSubject Index

Robert Lanza is an American scientist and author whose research spans the range of natural science, from biology to theoretical physics. TIME magazine recognized him as one of the “100 Most Influential People in the World,” and Prospect magazine named him one of the Top 50 “World Thinkers.” He has hundreds of scientific publications and over 30 books, including definitive references in the fields of stem cells, tissue engineering, and regenerative medicine. He’s a former Fulbright Scholar and studied with polio-pioneer Jonas Salk and Nobel laureates Gerald Edelman (known for his work on the biological basis of consciousness) and Rodney Porter. He also worked closely (and co-authored papers in Science on self-awareness and symbolic communication) with noted Harvard psychologist BF Skinner. Dr. Lanza was part of the team that cloned the world’s first human embryo, the first endangered species, and published the first-ever reports of pluripotent stem cell use in humans. Robert Langer received honorary doctorates from the ETH (Switzerland) in 1996 and the Technion (Israel) in 1997. Dr. Langer is the Kenneth J. Germeshausen Professor of Chemical and Biomedical Engineering at MIT. He received a Bachelor’s Degree from Cornell University in 1970 and a Sc.D. from MIT in 1974, both in chemical engineering. Dr. Langer has written 590 articles, 400 abstracts, 350 patents, and has edited 12 books.Dr. Langer has received over 70 major awards, including the Gairdner Foundation International Award, the Lemelson-MIT prize, the American Chemical Society (ACS) Polymer Chemistry and Applied Polymer Science Awards, Creative Polymer Chemistry Award (ACS, Polymer Division), the Pearlman Memorial Lectureship Award (ACD, Biochemical Technology Division), and the A.I.Ch.E’s Walker, Professional Progress, Bioengineering, and Stine Materials Science and Engineering Awards. In 1989, Dr. Langer was elected to the Institute of Medicine and the National Academy of Sciences, and in 1992 he was elected to both the National Academy of Engineering and to the National Academy of Sciences. He is the only active member of all 3 United States National Academies. Dr. Joseph P. Vacanti received his M.D. degree from the university of Nebraska in 1974. He received his training in general surgery at the Massachusetts General Hospital from 1974 through 1981 and in pediatric surgery at The Children’s Hospital, Boston from 1981 through 1983. He then received clinical training in transplantation from the University of Pittsburgh. He spent two years in the laboratories of Dr. M. Judah Folkman working in the filed on angiogenesis from 1977 through 1979. Upon completion of his training, Dr. Vacanti joined the staff in surgery at children’s Hospital in Boston and began clinical programs in pediatric liver transplantation and extracorporeal membrane oxygenation. In the laboratory, he continued studies in and began work in the filed of tissue engineering in 1985. Dr. Vacanti is now John Homans Professor of Surgery at Harvard Medical School, Visiting surgeon at Massachusetts General Hospital, director of the Wellman 6 Surgical laboratories, director of the Laboratory of Tissue Engineering and Organ Fabrication and Director of Pediatric Transplantation at Massachusetts General Hospital, Boston. He has authored more than 120 original reports, 30 book chapters, and 197 abstracts. He has more than 25 patents or patents pending in the United States, Europe, and Japan. Anthony Atala, MD, is the G. Link Professor and Director of the Wake Forest Institute for Regenerative Medicine. Seventeen of his lab’s technologies have been translated to patients, including the first tissue-engineered organ for permanent implantation in a human. His research led to the discovery of a multipotent source of stem cells from amniotic fluid and placenta, advances in 3D printing of tissues and organs, and body-on-a-chip technologies. His work was twice listed among Time Magazine’s top 10 medical breakthroughs of the year, and he is a recipient of the Smithsonian Ingenuity Award. He has published over 900 journal articles, is the editor of 25 books, and holds over 250 national and international patents. Dr. Atala is a member of the National Academy of Medicine, the National Academy of Inventors, and the American Institute for Medical and Biological Engineering.

• PART I – FoundationsChapter 1 – IntroductionBedir Tekinerdogan, Dominique Blouin, Hans Vangheluwe, Miguel Goulão, Paulo Carreira, Vasco AmaralChapter 2An Ontological Foundation for Understanding Multi-Paradigm Modeling for Cyber-Physical Systems R. Paige, M. van den BrandChapter 3Feature-based Survey of Cyber-Physical SystemsB. Akesson, J. Hooman, R. Dekker, W. Ekkelkamp, B. StottelaarPART II - TechniquesChapter 4 Current standards and best practices used in CPSG. Orhan & M. AksitChapter 5Tools and techniques used in different disciplines for CPS development: Modeling languagesS. Schuster, I. Schaefer, C. Seidl Chapter 6Tools and techniques used in different disciplines for CPS development: Interfaces for InteroperabilityO. Al-wadeai, A. García-Domínguez, A. Bagnato, A. Abhervé, K. Barmpis Chapter 7Tools and techniques used in different disciplines for CPS development: ProcessesY. Luo, J. Mengerink, M. van den Brand, R. SchiffelersChapter 8Requirements for future MPM4CPS modelling tools and techniquesB. Tekinerdogan, D. BlouinPART III – Application DomainsChapter 9Case Study: Alarm Detection and Monitoring of Smart Factory Environment using Hybrid Sensor Network L. Banjanovic-Mehmedovic, D. Blouin, F. Mehmedovic, M. ZukicChapter 10 Case Study: Embedded Devices Constantin-Bala Zamfirescu and Peter LarsenChapter 11Case Study: SmartLab Cloud System for IoTH. VangheluweChapter 12Automated Analysis of Model-Driven Artifacts in Industry – Big Data AnalyticsY. Luo, J. Mengerink, M. van den Brand, R. Schiffelers PART IV – EducationChapter 13On a MPM4CPS CurriculaV. Amaral, M. GoulãoChapter 14Developing a mutually-recognized cross-domain study program in cyber-physical systemsPaulo CarreiraGlossary Author IndexSubject Index