Principles of Downstream Techniques in Biological and Chemical Processes

Downstream processing is an essential practice in the production and purification of biosynthethic materials, which is especially important in the production of pharmaceutical products. This book covers the fundamentals and the design concepts of various downstream recovery and purification steps (unit operations) involved in biochemical and chemical processes. The book describes cell breakage and recovery of intracellular material, isolation of solids, product recovery, product enrichment, and product polishing and finishing. It also covers basic chemical engineering purification techniques such as distillation, absorption, adsorption, etc. Described in the book are several case studies that discuss the various unit operation in each of the processes. An important point to consider is the economics of the downstream operation, and this book provides practical information on capital costs and operating expenses in addition to other operating cost factors with respect to downstream processing. Green chemistry and safety issues are also addressed. Practicing chemical engineers in biotechnology and pharmaceutical chemistry and other areas will find this book valuable as a reference on downstream techniques used in biological processes. Students in chemical engineering would benefit from this book as well.