Primer on Cerebrovascular Diseases

Louis R. Caplan, M.D. (Editor)Beth Israel Deaconess Medical Center, Harvard University, Boston, MADr. Caplan is a world-renowned neuroscientist and a senior member of the Division of Cerebrovascular Disease at Beth Israel Deaconess Medical Center, Boston. He is a Professor of Neurology at Harvard Medical School, Boston, and the founder of the Harvard Stroke Registry. Dr. Caplan is the author or editor of 45 books and more than 700 articles in medical journals. He is a member of many professional societies, serving as an officer on committees for the American Heart Association, the American Academy of Neurology, and the American Neurological Association. He has served as the Chair of both the Boston Society of Neurology and the Chicago Neurological Society. José Biller, M.D., FACP, FAAN, FANA, FAHA Loyola University Chicago, Maywood, IL, USA Dr. José Biller is Professor of Neurology and Neurological Surgery and Chairperson of the Department of Neurology at Loyola University Chicago Stritch School of Medicine. Dr. Biller served as Director of the American Board of Psychiatry and Neurology (ABPN) from 1994 to 2001, and President of the ABPN in 2001. He is Chief Editor of the Journal of Stroke and Cerebrovascular Diseases , and an editorial board member and reviewer for an array of other national and international journals and publications. He is a Fellow of the American Academy of Neurology, American Neurological Association, American College of Physicians, and the Stroke Council of the American Heart Association. He has published more than 370 peer-reviewed articles, more than 150 book chapters, and numerous books. Megan Carroll Leary, M.D. (Editor)Department of Neurology, Lehigh Valley Hospital and Health Network, Allentown, PA USADr. Leary is a neurologist with 15 years clinical experience, who specializes in Neurology and Vascular Neurology. She currently is the Neurology Residency Program Director for Lehigh Valley Hospital and Health Network in Allentown, PA, and is an Assistant Professor of Neurology in affiliation with Morsani College of Medicine at the University of South Florida. Dr. Leary is also a consulting neurologist at Harvard Clinical Research Institute at Harvard Medical School. Additionally, Dr. Leary is a member of many professional societies and serves on the American Board of Psychiatry and Neurology's Vascular Neurology Examination Committee. Her interests include cryptogenic stroke, acute ischemic stroke, and the association between cardiac disease and stroke. Eng H. Lo is a basic neurovascular scientist. He helped develop the neurovascular unit concept (Lo, Nat Rev Neurosci 2003; Tiedt et al, Nat Rev Neurol 2022). Ajith J. Thomas, M.D. Beth Israel Deaconess Medical Center, Harvard University, Boston, MADr. Thomas is a Neurosurgeon Co- Director of the Brain Aneurysm Institute at Beth Israel Deaconess Medical Center. He is also an Assistant Professor of Neurosurgery at Harvard University Medical School. He is the Program director for the Cerebrovascular fellowship for cranial and endovascular neurosurgery and site director for the Beth Israel Deaconess Center Neurosurgery Residency program. He has authored more than 100 peer reviewed papers in neurosurgery and several book chapters. His clinical interests are Subarachnoid Hemorrhage; Aneurysms; Stroke; Arteriovenous Malformations; Trigeminal Neuralgia; Peripheral Nerve Disorders. He is board certified from the American Board of Neurological Surgery. Midori A. Yenari, M.D. University of California, San Francisco, San Francisco, CADr. Yenari specializes in vascular neurology, and is on the faculty in the Department of Neurology at the University of California, San Francisco. She is also a staff neurologist and stroke program director at the San Francisco Veterans Affairs Medical Center. Her research focuses on the cellular and molecular mechanisms of stroke and potential therapies particularly as they pertain to immune modulation and therapeutic hypothermia. Dr. Yenari is a fellow of the American Academy of Neurology, a fellow of the American Heart Association and has served on editorial boards for Stroke, Journal of Cerebral Blood Flow and Metabolism, Neurobiology of Disease and Translational Stroke Research. John H. Zhang, M.D., Ph.D. (Editor)Loma Linda University Medical School, Loma Linda, CADr. Zhang is currently Professor of Anesthesiology, Neurosurgery, Neurology, Basic Sciences (Physiology & Pharmacology), Pathology & Human Anatomy, and Nursing at Loma Linda University Medical Center. He also serves as Director of Center for Brain Hemorrhage Research, Vice-Chair, Department of Basic Sciences (Chief of Division of Physiology) and Director of Physiology Graduate Training Program, Director of Basic Science Research Division in Neurosurgery and Anesthesiology. Dr. Zhang’s research efforts have been supported by grants from American Heart Association, National Institute of Health, and Department of Defense as well as other Regional foundations and Industry with more than 23 million US dollars. Dr. Zhang has published more than 600 peer reviewed articles and has been invited to speak in meetings, seminars, and grand rounds more than 300 times.

• PART I. BASIC CHAPTERSSection 1. Anatomy and PhysiologySection 2. PathophysiologySection 3. NeuroprotectionSection 4. Molecular MechanismsSection 5. Models and MethodsPART II. CLINICAL CHAPTERSSection 6. Clinical Aspects: Medical and SurgicalSection 7. Medical Conditions and StrokeSection 8. Diagnostic TestingSection 9. Management