Predictive Modeling of Pharmaceutical Unit Operations

Preetanshu Pandey obtained his Bachelor’s chemical engineering degree from Indian Institute of Technology, Kanpur, India. He holds a M.S. and Ph.D. degree in chemical engineering from West Virginia University. He is currently working as a Principal Scientist at the Drug Product Science and Technology department at Bristol-Myers Squibb. At BMS, he is primarily involved with developing oral solid dosage drug products. Prior to joining BMS, he worked at Schering-Plough/Merck for over 3 years on drug product development of inhalation products. He is actively involved with AAPS and AICHE organizations and has chaired symposiums and open forums in previous annual meetings. He serves as a reviewer for multiple journals and has authored over 40 peer-reviewed publications, 3 patent applications, and 3 invited book chapters. Dr. Rahul Bharadwaj is the Vice-President of Engineering and Business Development at Rocky DEM, Inc. Dr. Bharadwaj has over a decade of experience in the development, validation and application of computational tools such as Discrete Element Modeling (DEM), Computational Fluid Dynamics and Finite Element Analyses for industries such as pharmaceutical, chemical, agriculture, mining, oil & gas, etc. He received his M.S. in Mechanical Engineering from the University of Kentucky (2003) and a Ph.D. in Mechanical Engineering from Purdue University (2006). He has since then held positions as senior scientist in Pfizer R&D and also as a consulting engineer at Jenike and Johanson Inc. He is also an active member of American Institute of Chemical Engineers (AIChE), American Association of Pharmaceutical Scientists (AAPS), and is the founder and past-chair of its Process Modeling and Simulation Focus Group

• 1. Modeling of drug product manufacturing processes in the pharmaceutical industry2. Quality risk management for pharmaceutical manufacturing: The role of process modeling and simulations3. Powder flow and blending4. Dry granulation process modeling5. Mechanistic modeling of high-shear and twin screw mixer granulation processes6. Fluid bed granulation and drying7. Modeling of milling processes via DEM, PBM, and microhydrodynamics8. Modeling of powder compaction with the drucker–prager cap model9. Modeling approaches to multilayer tableting10. Computational modeling of pharmaceutical die filling processes11. Modeling tablet film-coating processes12. Modeling in pharmaceutical packaging13. Continuous secondary process selection and the modeling of batch and continuous wet granulation14. Process modeling in the biopharmaceutical industry