Precision Molecular Pathology of Lung Cancer

Philip T. Cagle, MDHouston Methodist HospitalDepartment of Pathology & Genomic Medicine6565 Fannin StHouston, TX 77030Timothy C. Allen, MDThe University of Texas Medical Branch Department of Pathology301 University BoulevardGalveston, TX 77555Mary Beth Beasley, MDMount Sinai HospitalDepartment of Pathology1468 Madison AvenueNew York, NY 10029Lucian R. Chirieac, MDBrigham And Women's HospitalDepartment of Pathology75 Francis St.Boston, MA 02115Sanja Dacic, MD, PhDUniversity of Pittsburgh Medical CenterDepartment of Pathology200 Lothrop St.Pittsburgh, PA 15213Alain C. Borczuk, MDWeill Cornell University Medical CenterDepartment of Pathology1300 York AvenueStarr-1000ANew York, NY 10065Keith M. Kerr, MDAberdeen University Medical SchoolAberdeen Royal InfirmaryDepartment of PathologyForesterhillAberdeen, ScotlandLynette Sholl, MDBrigham And Women's HospitalDepartment of Pathology75 Francis StBoston, MA 02115Bryce Portier, MDHouston Methodist HospitalDepartment of Pathology & Genomic Medicine6565 Fannin StHouston, TX 77030Eric Bernicker, MDHouston Methodist HospitalThoracic Medical Oncology6445 Main St, Floor 21Houston, TX 77030

• I. Background.- 1. Precision Medicine of Lung Cancer: Introduction.- 2. Lung Cancer Epidemiology and Demographics.- 3. Genetic Susceptibility to Lung Cancer.- 4. Lung Cancer Stem Cells.- 5. The 2015 World Health Organization Classification of Lung Cancer: Overview.- II. Testing Methods.- 6. Preanalytic considerations.- 7. Mutation testing of lung cancer biomarkers.- 8. Translocation testing of lung cancer biomarkers.- 9. Immunohistochemistry of lung cancer biomarkers.- 10. Next Generation and Third Generation Sequencing of lung cancer biomarkers.- III. Molecular Pathology of Specific Cell Types.- 11. Mutations as Predictive Biomarkers for Adenocarcinoma.- 12. Translocations as predictive Biomarkers for Adenocarcinoma.- 13. Predictive Biomarkers for Squamous Cell Carcinoma.- 14. Molecular Pathology of Small Cell Carcinoma.- 15. Molecular Pathology of Uncommon Carcinomas.- 16. Molecular Pathology of Lung Cancer Metastases.- 17. Molecular Pathology of Precursor and Preinvasive Lesions.- IV. General and Emerging Fields in Molecular Pathology of Lung Cancer.- 18. Prognostic biomarkers in lung cancer.- 19. Biomarkers and Differing Therapy Modalities.- 20. Immuno-oncology of Lung Cancer.- 21. Liquid Biopsy.