Precision Medicine in Neurodegenerative Disorders

Dr. Alberto Espay is Professor and Endowed Chair of the James J. and Joan A. Gardner Center for Parkinson’s disease at the University of Cincinnati. He has published over 300 peer-reviewed research articles and 8 books, including Common Movement Disorders Pitfalls, which received the Highly Commended BMA Medical Book Award in 2013 and Brain Fables, the Hidden History of Neurodegenerative Diseases and a Blueprint to Conquer them, coauthored with Parkinson patient and advocate Benjamin Stecher, selected by the Association of American Publishers for the PROSE Award honoring the best scholarly work in Neuroscience published in 2020. He has served as Chair of the Movement Disorders Section of the American Academy of Neurology, Associate Editor of the Movement Disorders journal, and on the Executive Committee of the Parkinson Study Group. Among other honors, he has received the Cincinnati Business Courier’s Health Care Hero award, the Spanish Society of Neurology’s Cotzias award, and honorary membership in the Mexican Academy of Neurology. He currently serves as President-Elect of the Pan-American Section of the International Parkinson and Movement Disorders Society. With colleagues at the University of Cincinnati, he launched the first biomarker study of aging (CCBPstudy.com), designed to match people with neurodegenerative disorders to available therapies from which they are most biologically suitable to benefit, regardless of their clinical diagnoses.

• Part 1 Conceptual Framework1. The definition of precision medicine in neurodegenerative disorders and the one disease-many-diseases tension2. Models of precision medicine for neurodegeneration3. Pathology vs pathogenesis: Rationale and pitfalls in the clinicopathology model of neurodegeneration4. Mixed pathology as a rule, not exception: Time to reconsider disease nosology?5. Neurodegenerative disorders: From clinicopathology convergence to systems biology divergence6. The emergence of genotypic divergence and future precision medicine applications7. Lessons from other fields of medicine, Part 1: Breast cancer8. Lessons from other fields of medicine, Part 2: Cystic fibrosis9. Lessons learned from evolving frameworks in adult glioblastomaPart 2 Pitfalls in Definitions, Cohorts, and Measures of Progression10. Finding the falsification threshold of the toxic proteinopathy hypothesis in neurodegeneration11. The theoretical problems of “prodrome” and “phenoconversion” in neurodegeneration12. The dilemma between milestones of progression vs. clinical scales in Parkinson disease13. Biomarkers of diagnosis, prognosis, pathogenesis, response to therapy: Convergence or divergence? Lessons from Alzheimer Disease and synucleinopathies14. Challenges in the study of individuals at risk for Parkinson disease15. The challenging quest of neuroimaging: From clinical to molecular-based subtyping of Parkinson disease and atypical parkinsonisms

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