Precision Medicine, AI and the Science of Personalized Healthcare

JAMES WALLACE is the former CEO of DecisionRx, a medication therapy optimization company. He is a Senior Researcher at Harvard Business School. Wallace was previously the Head of Strategy for Anthem, the President of AmeriPlus, a combat pilot with the United States Army, and a strategy consultant with Bain & Company.

• Foreword xviiPreface xixIntroduction: The Dawn of a New Era xxiChapter 1 Michael and Jennifer: A Family’s Fight Against Obesity 1Michael: The Silent Fighter 3Jennifer: The Hopeful Realist 6The Wearable Catalyst 10A Hopeful Future 19Chapter 2 Wearable Devices 21Chronic Conditions: A Growing Concern 22Wearables and Precision Medicine: Tailoring Health Solutions 28Costs and Outcomes of Wearable Devices: Traditional vs. Precision Medicine 42Notes 53Chapter 3 The Science of Hope 59Simplifying Precision Medicine 60How It Works: From Data to Decisions 60The Patient Perspective: Benefits Made Simple 62Understanding the Impact of Wearables, Pharmacogenomics, Big Data Analytics, and Artificial Intelligence 65Macro-Level Cost and Outcomes 70The Universal Benefits of Precision Medicine 75Notes 80Chapter 4 Emily’s Unrest 85A Life of Contrasts 85Breaking Point 93Pharmacogenomics: A Tailored Solution 100A Renewed Emily 103Chapter 5 Genetics and Medication Management 107Medication Failure in Traditional Care 108Precision Medicine’s Approach: Eliminating Trial and Error 113The Role of Pharmacogenomics in Precision Medicine 122Comparison of Cost and Outcomes: Traditional vs. Precision Medicine 129Notes 134Chapter 6 Through the Lens Clearly 141Assembling the Pieces: The History of Medical Innovation 142Implementing the Insights: From Bloodletting to Precision Medicine 152Integrating the Outcomes: The Rise of Individualized Care 158Notes 164Chapter 7 The Joy and Pain of Being Amy 167The Value of Work 168A Lifetime of Shrugged Shoulders 172A Voice of Concern 175Treating the Person, Not the Symptoms 176The Power of Knowing Why 177It Takes a Village 180Chapter 8 Pain and Personalized Therapy 185The Hidden Epidemic of Pain 186Data as Cure 191Precision Pain Management in Action 198Cost and Outcomes of Precision Pain Management 200Notes 205Chapter 9 Barriers to Access 209The Challenges of Precision Medicine 210Social Determinants of Health and Access to Care 217Notes 221Chapter 10 Susan, Family, and Cancer 223Peggy Sue Got Married 223The Family Years 225Tuesday Afternoon 226A Different Kind of Doctor 228The Machine That Thinks 229Moving the Mountain 232A Life Reclaimed 234Chapter 11 Artificial Intelligence and the Human Genome 237The Intersection of Information and Artificial Intelligence 238Genetic and Genomic Medicine 242Cost and Outcomes: Advanced Personalized Treatments 252Companies Shaping the Future of AI-Enabled Medicine 259Notes 263Chapter 12 A Vision for the Future 271What’s Next for Precision Medicine 272Implications for Traditional Medicine 277How Precision Medicine Will Shape Personalized Healthcare 283Notes 287Conclusion: Making Medicine Personal 291The Personal Healthcare Journey 291Common Themes from our Guides: What We Can Learn 294How You Can Explore Precision Medicine for Yourself 296Call to Action: A Roadmap for Leaders, Investors, and Policymakers 299Notes 302Acknowledgments 303About the Author 305Index 307