Precision 3D Printing in Pharmaceutical Sciences

Kuldeep Vinchurkar, PhD, works in the Department of Pharmaceutics, Sandip Institute of Pharmaceutical Sciences, affiliated to Savitribai Phule Pune University, Nashik, Maharashtra, India with more than 11 years of research and teaching experience. He has published five books, seven patents, and more than 30 research and review publications in national and international journals. His research interests include 3D printing, artificial intelligence, and novel drug delivery systems, especially gastroretentive drug delivery. Sheetal Mane, PhD is an Assistant Professor of Pharmaceutics at NMT Gujarati College of Pharmacy, Indore, Madhya Pradesh, India and has more than nine years of experience. She has published eight book chapters and 17 research papers in reputed journals and conferences. Her research focuses on novel drug delivery systems. Dinesh Kumar Mishra, PhD is a Professor in the Department of Pharmacy at Guru Ghasidas Vishwavidyalaya with more than 20 years of experience in teaching, research, and administration. He holds three national patents and has authored five books, ten chapters, and more than 80 publications in peer-reviewed national and international journals. He specializes in novel drug delivery systems, particularly lipid-based nanocarriers, transdermal drug delivery, vaccines, and product development.

• Preface xxiiiPart I: Fundamentals of 3D Printing in Pharmaceuticals 11 Introduction to 3D Printing in Pharmaceuticals 3Sachin Joshi, Priya Jindal, Balak Das Kurmi, Manish Kumar and Kuldeep Vinchurkar1.1 Introduction 41.2 Categories of 3D Printing Methods in Drug Delivery 61.3 3D printing Materials Utilized for Pharmaceuticals 91.4 Drug Delivery Technology in 3D Printing 111.5 Various Applications of 3D Printing 141.6 Possibilities and Difficulties Associated with Applying 3D Printing to Medicine 171.7 Conclusion and Recommendations for the Future 182 Fundamentals of Pharmaceutical 3D Printing 23Hardik Rana, Mansi Dholakia, Vimal Patel, Saloni Dalwadi and Kuldeep Vinchurkar2.1 Design to Object 242.2 Types of 3D Printing Material 632.3 Key Components of a 3D Printer 682.4 Software and Tools for 3D Printing 823 Advancements and Applications of 3D Bioprinting in Pharmaceutical Research: A Comprehensive Review 105Amar Deshpande, Shilpa S. Borkar, Ketki Bhatt, Koustubha S. Pachkor, Satish Polshetttiwar and Jagdish Baheti3.1 Introduction 1063.2 Classification of 3D Bioprinting (3DBP) 1073.3 Methods for Bioprinting 1083.4 Inkjet-Based Bioprinting 1113.5 Bioprinting Material 1153.6 Applications 1183.7 Advantages 1193.8 Disadvantages 1193.9 Future Prospective 1203.10 Conclusion 1204 3D Printing of Solid Dosage Forms 129Ashwin Kuchekar, Prajakta Wagh, Harshavardhan Karnik and Ashwini Gawade4.1 Introduction 1304.2 Types of 3D Printing Technologies for Solid Dosage Forms 1334.3 Materials Used in 3D Printing of Solid Dosage Forms 1394.4 Design and Formulation Considerations in 3D Printing of Oral Solid Dosage Forms 1424.5 Manufacturing Process 1444.6 Quality Control and Regulatory Aspects 1514.7 Case Studies and Applications 1604.8 Advantages of 3D Printing in Healthcare Industry 1634.9 Future Directions and Innovations in 3D Printing for Pharmaceuticals 1654.10 Conclusion 167Part II: Applications of 3D Printing in Pharmaceuticals 1755 3D Printing of Controlled Release Systems 177Chirag Jain, Shubham Kumar, Shreya Kaul, Manisha Pandey, Bapi Gorain, Najwa Mohamad and Neha Jain5.1 Introduction 1785.2 Technologies Utilized in 3D Printing 1815.3 Recent Advances in 3D Printing of Controlled Release Systems 1835.4 Technology Lab to Market 1935.5 Conclusion 2006 Fabrication of Implants and Medical Devices via Three-Dimensional Printing Technology 207Ruchira Srivastava and Ayushi Thakur6.1 Introduction 2076.2 Various Categories of Three-Dimensional Printing Techniques 2096.3 Applications in Medical Devices and Implants 2176.4 Advantages: 3D Printing in Medical Applications 2226.5 Challenges and Considerations of 3D Printing in Medical Applications 2236.6 Conclusion 2247 3D Printing in Drug Delivery System 229Satish Polshettiwar, Shrikant Dargude, Pranali Polshettiwar, Saloni Ghodmare, Swati Jagdale and Kuldeep Vinchurkar7.1 Introduction 2307.2 3D-Printed Drug Delivery System 2327.3 Applications of 3D Printing in Drug Delivery 2457.4 Challenges and Limitations 2477.5 Conclusion 2488 3D Bioprinting in Pharmaceutical Research 257Vijaya Padwal, Sachin Kothawade, Sandesh Bole and Kuldeep Vinchurkar8.1 Introduction 2588.2 Significance in Pharmaceutical Research 2598.3 Objectives and Structure 2618.4 Principles of 3D Bioprinting 2628.5 Types of Bioprinting 2648.6 Types of 3D Bioprinters 2698.7 Materials Used for Bioprinting 2738.8 Drug Evaluation 2798.9 Drug Delivery 2808.10 Customization of Patient-Specific Medications/Personalized Medicine 2828.11 3D Printing Method and Techniques 2838.12 Applications of 3D Printing in Personalized Medicines 2848.13 Conclusion 2869 Case Studies and Success Stories of Companies Leveraging 3D Printing Technology 295Debarshi Kar Mahapatra, Kuldeep Vinchurkar and Dinesh Kumar Mishra9.1 Introduction 2969.2 Technology and Future 2989.3 Case and Success Studies of Companies Leveraging 3D Printing Technology 3009.4 Conclusion 319Part III: Regulatory, Commercial, and Sustainability Aspects 32310 Regulatory and Quality Considerations in 3D Printing Technology 325Chaitanay Vinayak Narayan, Manasvi Saini, Swati Verma, Ajmer Singh Grewal and Kunal Nepali10.1 Introduction 32610.2 Patient Safety Concerns with 3D-Printed Medical Products 33210.3 Legal and Regulatory Framework for 3D Printing of Medical Devices 33210.4 Regulatory Standards for 3D-Printed Pharmaceuticals 33610.5 Conclusion 33911 Intellectual Property Issues in Pharmaceutical 3D Printing 345Varalaxmi Sagili, Sarad Pawar Naik Bukke, Shanmugam Vippamakula, Buyinza Nichola and Kabali Moses12 Economic and Commercial Aspects of 3D Printing Technology 365Sarad Pawar Naik Bukke, Varalaxmi Sagili, Shanmugam Vippamakula, Allan Amooti Ahikiriza and Muhamad Mustafa Mundu12.1 Overview of 3D Printing Technologies Used in Pharmaceutical Industries 36712.2 3D Printing Technologies Used in the Manufacture of Drug Delivery Systems in the Pharmaceutical Industry 37212.3 Development and Commercialization of 3D Printing Technologies in Pharmaceuticals According to Patient Preferences 37512.4 Current Scenario in Large-Scale Manufacturing of 3D Printing Pharmaceuticals 37812.5 3D Printing in Personalized Medicine 37912.6 Future Impacts of 3D Printing on the Pharmaceutical Industrial Sector 38013 Environment Impact and Sustainability of 3D Printing in Pharmaceuticals 383Buyinza Nicholas, Varalaxmi Sagili, Sarad Pawar Naik Bukke, Allan Amooti Ahikiriza and Kasolo Daniel13.1 Introduction 38413.2 Additives Used in 3D Printing 38513.3 3D Printing Method and Its Impact on the Environment 39013.4 Index of Greenness Assessment of Printed Pharmaceuticals 39113.5 Life Cycle Analysis (LCA) of 3D Printing 39313.6 Substitution of Energy Sources 39413.7 Sustainability in 3D Printing 39413.8 Limitations and Future Perspectives 39413.9 Conclusion 395Part IV: Challenges Future Perspectives 39714 Challenges and Ethical Considerations in 3D Printing Technology 399Mallamma T., Prakash Goudanavar, Pranav Nayak, Moumita Banerjee and Kuldeep Vinchurkar14.1 Introduction 40014.2 Technical Challenges in 3D Printing: Material Limitations 40114.3 Technical Challenges in 3D Printing: Scalability 40414.4 Case Studies and Applications 40714.5 Economic and Business Challenges of 3D Printing Technology: Cost Considerations 40814.6 Economic and Business Challenges of 3D Printing Technology: Market Adoption 40914.7 Economic and Business Challenges 41114.8 Ethical Considerations 41314.9 Ethical Considerations: Accessibility and Equality in 3D Printing Technology 41614.10 Legal and Social Challenges in 3D Printing Technology 41814.11 Healthcare: Case Studies on the Use of 3D Printing in Healthcare 42214.12 Challenges and Ethical Considerations in 3D Printing Technology: Aerospace and Defense 42414.13 Challenges and Ethical Considerations in 3D Printing Technology: Consumer Goods 42614.14 Challenges and Ethical Considerations in 3D Printing Technology: Future Directions and Recommendations 42814.15 Ethical Challenges in Clinical Applications 43014.16 Future Recommendations for Policy and Practice 43214.17 Conclusion 43415 Future Directions and Emerging Trends in 3D Printing Integrating with Artificial Intelligence and Machine Learning 443Sutapa Biswas Majee, Sudarshan Singh, Ushasi Das, Dhruti Avlani, Rachayeeta Bera, Shourya Karmakar and Kuldeep Vinchurkar15.1 Introduction 44415.2 Basic Concepts of 3D Printing and 3D Bioprinting 44515.3 Trends in Progress in 3DP and 3DBP 44915.4 Need for Artificial Intelligence and Machine Learning in 3D Printing Technology in Pharmaceutical and Healthcare Industries 45115.5 Artificial Intelligence and Machine Learning: Brief Overview 45215.6 Future Prospects and Emerging Trends in AI-Driven 3D Printing 46815.7 Conclusion 471References 472Index 489