Practical Process Research and Development

Nyhet

A Guide for Organic Chemists

Häftad, Engelska, 2026

AvNeal G. Anderson,Neal G Anderson

1 869 kr

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Practical Process Research and Development: A Guide for Organic Chemists, Third Edition provides a concise, comprehensive, step-by-step framework to support understanding and implement organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries. The book describes the steps taken following synthesis and evaluation to bring key compounds to market in a cost-effective manner. Through a hands-on, step-by-step approach to solving process development problems, including route, reagent, and solvent selection, optimizing catalytic reactions, chiral syntheses, and green chemistry, this book helps organic, medicinal, pharmaceutical, and chemical process development chemists as well as chemical engineers with research and development initiatives.
In addition, it is well suited for beginners at upper undergraduate and graduate student level and early career researchers who need accessible insights into industrial process R&D.

Reflects the current thinking in chemical process R&D for small molecules
Provides insights into generating rugged, practical, cost-effective processes for the chemical preparation of small molecules
Breaks down process optimization into route, reagent and solvent selection, development of reaction conditions, workup, crystallizations, and more
Presents guidelines for implementing and troubleshooting critical processes
Includes various problem sets, providing readers with the opportunity to reflect on the course material and real-life situations
Provides a framework for practical chemical process development for those new to the industry
Includes examples to aid researchers who have been conducting industrial process R&D

Produktinformation

Utgivningsdatum2026-08-01
Mått152 x 229 x undefined mm
Vikt450 g
FormatHäftad
SpråkEngelska
Antal sidor512
Upplaga3
FörlagElsevier Science
ISBN9780443365225

Tillhör följande kategorier

Farmakologi inom Medicin
Organisk kemi inom Naturvetenskap och teknik
Tillverkningsteknik inom Naturvetenskap och teknik

Neal G. Anderson is a synthetic organic chemist with over 40 years of experience in chemical process R&D in the pharmaceutical industry. He earned a B.S. degree in biology from the University of Illinois and a Ph.D. in medicinal chemistry from the University of Michigan, followed by industrial post-doctoral studies at McNeil Laboratories. He has extensive hands-on experience in the laboratory, pilot plant, and in manufacturing facilities. At Squibb / Bristol-Myers Squibb he made key contributions to processes for the manufacture of four major drug substances, including captopril, and has participated in 12 manufacturing start-ups and introductions of many processes to pilot plants. He received a BMS President's Award and spot awards, and his final position was Principal Scientist. In 1997, Anderson established Anderson’s Process Solutions L.L.C., a consulting firm based in the USA to offer practical guidance on developing and implementing processes for bulk pharmaceuticals and fine chemicals. As part of these consulting services, he presents courses on selected aspects of practical process R&D. He is experienced in laboratory research, scale-up, and technology transfer to ensure reproducibility and optimal product quality.

1. Introduction2. Safety Reactions3. Route selection4. Reagent selection5. Solvent selection6. Practical considerations for scale-up7. In-process controls and reaction duration8. Process optimization by minimizing impurities9. Work-up conditions10. Purification, crystallization and isolation11. Final product form and impurities12. Continuous operations13. Scale-up concerns, validation, and process implementation14. Trouble-shooting