Nigel S. Key, Harold R. Roberts Distinguished Professor, Division of Hematology and Oncology, Department of Medicine, University of North Carolina School of Medicine, North Carolina, Chapel Hill, USA Michael Makris, Senior Lecturer in Haematology, Department of Medicine and Pharmacology, University of Sheffield, Sheffield, UKDavid Lillicrap, Professor of Hematology, Department of Pathology and Molecular Medicine, Richardson Laboratory, Queen's University, Kingston, Ontario, Canada

• List of Contributors ix1 Basic Principles Underlying Coagulation 1Dougald M. Monroe2 Laboratory Tests of Hemostasis 12Steve Kitchen and Michael Makris3 Molecular Diagnostic Approaches to Hemostasis 27Paula James and David Lillicrap4 Tests of Platelet Function 42Marie Lordkipanidzé, Gillian C. Lowe and Paul Harrison5 Evaluation of the Bleeding Patient 63Alice Ma and Marshall Mazepa6 Hemophilia A and B 79Rhona M. Maclean and Michael Makris7 Von Willebrand disease 94Giancarlo Castaman, Alberto Tosetto and Francesco Rodeghiero8 The Rarer Inherited Coagulation Disorders 113Paula H.B. Bolton‐Maggs, Jonathan Wilde and Gillian N. Pike9 Acquired Inhibitors of Coagulation 124Riitta Lassila and Elina Armstrong10 Quantitative Platelet Disorders 134Riten Kumar and Walter H.A. Kahr11 Qualitative Platelet Disorders 160Eti A. Femia Gian Marco Podda and Marco Cattaneo12 Disseminated Intravascular Coagulation 172Raj S. Kasthuri and Nigel S. Key13 Thrombotic Microangiopathies 183Marie Scully and David Kavanagh14 Venous Thromboembolism 195Sarah Takach Lapner, Lori-Ann Linkins and Clive Kearon15 Myeloproliferative Neoplasms: Thrombosis and Hemorrhage 210Brandi Reeves and Stephan Moll16 Arterial Thrombosis 229R. Campbell Tait and Catherine N. Bagot17 Anticoagulation: Heparins and Vitamin K Antagonists 240Gualtiero Palareti and Benilde Cosmi18 The Direct Oral Anticoagulants 253David A. Garcia, Mark A. Crowther and Walter Ageno19 Antiphospholipid Syndrome 269Henry G. Watson and Mark Crowther20 Cardiovascular Medicine 282Sreekanth Vemulapalli and Richard C. Becker21 Cardiothoracic Surgery 299Denise O’Shaughnessy and Ravi Gill22 Neurology 314Michael Wang, Natalie Aucutt-Walter, Valerie L. Jewells and David Y. Huang23 Hepatology 329Lara N. Roberts, Raj K. Patel and Roopen Arya24 Nephrology 340Vimal K. Derebail and Thomas L. Ortel25 Oncology 355Anna Falanga and Marina Marchetti26 Obstetrics, Contraception, and Estrogen Replacement 379Amy Webster and Sue Pavord27 Pediatrics 393Mary E. Bauman, Aisha Bruce and M. Patricia Massicotte28 Intensive and Critical Care 414Beverley J. Hunt29 Transfusion 433Adrian CopplestoneAppendix 1 Reference Ranges 444Steve Kitchen and Michael MakrisIndex 452

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Nigel S. Key, Harold R. Roberts Distinguished Professor, Division of Hematology and Oncology, Department of Medicine, University of North Carolina School of Medicine, North Carolina, Chapel Hill, USA Michael Makris, Senior Lecturer in Haematology, Department of Medicine and Pharmacology, University of Sheffield, Sheffield, UKDavid Lillicrap, Professor of Hematology, Department of Pathology and Molecular Medicine, Richardson Laboratory, Queen's University, Kingston, Ontario, Canada

• List of Contributors ix1 Basic Principles Underlying Coagulation 1Dougald M. Monroe2 Laboratory Tests of Hemostasis 12Steve Kitchen and Michael Makris3 Molecular Diagnostic Approaches to Hemostasis 27Paula James and David Lillicrap4 Tests of Platelet Function 42Marie Lordkipanidzé, Gillian C. Lowe and Paul Harrison5 Evaluation of the Bleeding Patient 63Alice Ma and Marshall Mazepa6 Hemophilia A and B 79Rhona M. Maclean and Michael Makris7 Von Willebrand disease 94Giancarlo Castaman, Alberto Tosetto and Francesco Rodeghiero8 The Rarer Inherited Coagulation Disorders 113Paula H.B. Bolton‐Maggs, Jonathan Wilde and Gillian N. Pike9 Acquired Inhibitors of Coagulation 124Riitta Lassila and Elina Armstrong10 Quantitative Platelet Disorders 134Riten Kumar and Walter H.A. Kahr11 Qualitative Platelet Disorders 160Eti A. Femia Gian Marco Podda and Marco Cattaneo12 Disseminated Intravascular Coagulation 172Raj S. Kasthuri and Nigel S. Key13 Thrombotic Microangiopathies 183Marie Scully and David Kavanagh14 Venous Thromboembolism 195Sarah Takach Lapner, Lori-Ann Linkins and Clive Kearon15 Myeloproliferative Neoplasms: Thrombosis and Hemorrhage 210Brandi Reeves and Stephan Moll16 Arterial Thrombosis 229R. Campbell Tait and Catherine N. Bagot17 Anticoagulation: Heparins and Vitamin K Antagonists 240Gualtiero Palareti and Benilde Cosmi18 The Direct Oral Anticoagulants 253David A. Garcia, Mark A. Crowther and Walter Ageno19 Antiphospholipid Syndrome 269Henry G. Watson and Mark Crowther20 Cardiovascular Medicine 282Sreekanth Vemulapalli and Richard C. Becker21 Cardiothoracic Surgery 299Denise O’Shaughnessy and Ravi Gill22 Neurology 314Michael Wang, Natalie Aucutt-Walter, Valerie L. Jewells and David Y. Huang23 Hepatology 329Lara N. Roberts, Raj K. Patel and Roopen Arya24 Nephrology 340Vimal K. Derebail and Thomas L. Ortel25 Oncology 355Anna Falanga and Marina Marchetti26 Obstetrics, Contraception, and Estrogen Replacement 379Amy Webster and Sue Pavord27 Pediatrics 393Mary E. Bauman, Aisha Bruce and M. Patricia Massicotte28 Intensive and Critical Care 414Beverley J. Hunt29 Transfusion 433Adrian CopplestoneAppendix 1 Reference Ranges 444Steve Kitchen and Michael MakrisIndex 452

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Nigel S. Key, Harold R. Roberts Distinguished Professor, Division of Hematology and Oncology, Department of Medicine, University of North Carolina School of Medicine, North Carolina, Chapel Hill, USA Michael Makris, Senior Lecturer in Haematology, Department of Medicine and Pharmacology, University of Sheffield, Sheffield, UKDavid Lillicrap, Professor of Hematology, Department of Pathology and Molecular Medicine, Richardson Laboratory, Queen's University, Kingston, Ontario, Canada

• List of Contributors ix1 Basic Principles Underlying Coagulation 1Dougald M. Monroe2 Laboratory Tests of Hemostasis 12Steve Kitchen and Michael Makris3 Molecular Diagnostic Approaches to Hemostasis 27Paula James and David Lillicrap4 Tests of Platelet Function 42Marie Lordkipanidzé, Gillian C. Lowe and Paul Harrison5 Evaluation of the Bleeding Patient 63Alice Ma and Marshall Mazepa6 Hemophilia A and B 79Rhona M. Maclean and Michael Makris7 Von Willebrand disease 94Giancarlo Castaman, Alberto Tosetto and Francesco Rodeghiero8 The Rarer Inherited Coagulation Disorders 113Paula H.B. Bolton‐Maggs, Jonathan Wilde and Gillian N. Pike9 Acquired Inhibitors of Coagulation 124Riitta Lassila and Elina Armstrong10 Quantitative Platelet Disorders 134Riten Kumar and Walter H.A. Kahr11 Qualitative Platelet Disorders 160Eti A. Femia Gian Marco Podda and Marco Cattaneo12 Disseminated Intravascular Coagulation 172Raj S. Kasthuri and Nigel S. Key13 Thrombotic Microangiopathies 183Marie Scully and David Kavanagh14 Venous Thromboembolism 195Sarah Takach Lapner, Lori-Ann Linkins and Clive Kearon15 Myeloproliferative Neoplasms: Thrombosis and Hemorrhage 210Brandi Reeves and Stephan Moll16 Arterial Thrombosis 229R. Campbell Tait and Catherine N. Bagot17 Anticoagulation: Heparins and Vitamin K Antagonists 240Gualtiero Palareti and Benilde Cosmi18 The Direct Oral Anticoagulants 253David A. Garcia, Mark A. Crowther and Walter Ageno19 Antiphospholipid Syndrome 269Henry G. Watson and Mark Crowther20 Cardiovascular Medicine 282Sreekanth Vemulapalli and Richard C. Becker21 Cardiothoracic Surgery 299Denise O’Shaughnessy and Ravi Gill22 Neurology 314Michael Wang, Natalie Aucutt-Walter, Valerie L. Jewells and David Y. Huang23 Hepatology 329Lara N. Roberts, Raj K. Patel and Roopen Arya24 Nephrology 340Vimal K. Derebail and Thomas L. Ortel25 Oncology 355Anna Falanga and Marina Marchetti26 Obstetrics, Contraception, and Estrogen Replacement 379Amy Webster and Sue Pavord27 Pediatrics 393Mary E. Bauman, Aisha Bruce and M. Patricia Massicotte28 Intensive and Critical Care 414Beverley J. Hunt29 Transfusion 433Adrian CopplestoneAppendix 1 Reference Ranges 444Steve Kitchen and Michael MakrisIndex 452

Select Guide Rating