In this issue of Surgical Pathology Clinics, guest editor Dr. Nicole C. Panarelli brings her considerable expertise to the topic of Practical Approach to Controversies in the Gastrointestinal Tract. Top experts provide a critical analysis of the literature surrounding evolving practices in gastrointestinal pathology. Each article includes a balanced discussion of evidence that does or does not support current practice, and provides perspectives on imminent developments where appropriate, all with an emphasis on use, interpretation, and limitations of histologic grading, ancillary studies, and other quantitative and qualitative indices.