Del i serien Archives of Virology. Supplementa

Positive-Strand RNA Viruses

Häftad, Engelska, 1994

AvMargo A. Brinton,Charles H. Calisher,Roland Rueckert

709 kr

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Positive-strand RNA viruses include the majority of the plant viruses, a number of insect viruses, and animal viruses, such as coronaviruses, togaviruses, flaviviruses, poliovirus, hepatitis C and rhinoviruses. This volume contains the contributions of over 50 leading laboratories on strategies for the control of virus diseases: molecular aspects of pathogenesis and virulence; genome replication and transcription; RNA recombination; RNA-protein interactions and host-virus interactions; protein expression and virion maturation; RNA replication; virus receptors; and virus structure and assembly. Highlights include analysis of the picornavirus IRES element, evidence for long-term persistence of viral RNA in host cells, acquisition of new genes from the host and other viruses via copy-choice recombination, identification of molecular targets and use of structural and molecular biological studies for development of novel antiviral agents.

Produktinformation

Utgivningsdatum1994-03-16
Mått210 x 279 x 31 mm
Vikt1 375 g
FormatHäftad
SpråkEngelska
SerieArchives of Virology. Supplementa
Antal sidor558
FörlagSpringer Verlag GmbH
ISBN9783211825228

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Biologi inom Naturvetenskap och teknik

Keynote address.- The importance of antigenic variation in vaccine design.- Strategies for control of virus diseases.- The genetic and functional basis of HIV-1 resistance to nonnucleoside reverse transcriptase inhibitors.- Structure-based design of symmetric inhibitors of HIV-1 protease.- Age-dependent susceptibility to fatal encephalitis: alphavirus infection of neurons.- Principles and background for the construction of transgenic plants displaying multiple virus resistance.- The structure of an immunodominant loop on foot and mouth disease virus, serotype O1, determined under reducing conditions.- Immunopathologic mechanisms of dengue hemorrhagic fever and dengue shock syndrome.- Molecular aspects of pathogenesis and virulence.- Cardioviral poly(C) tracts and viral pathogenesis.- Transgenic mice and the pathogenesis of poliomyelitis.- Adaptation of positive-strand RNA viruses to plants.- A molecular genetic approach to the study of Venezuelan equine encephalitis virus pathogenesis.- Use of drug-resistance mutants to identify functional regions in picornavirus capsid proteins.- Flock house virus: a simple model for studying persistent infection in cultured Drosophila cells.- Genome replication and transcription.- Protein-protein interactions and glycerophospholipids in bromovirus and nodavirus RNA replication.- Characteristics of the poliovirus replication complex.- Secretory pathway function, but not cytoskeletal integrity, is required in poliovirus infection.- Role of sub-genomic minus-strand RNA in Coronavirus replication.- Common replication strategies emerging from the study of diverse groups of positive-strand RNA viruses.- Preferential replication of defective turnip yellow mosaic virus RNAs that express the 150-kDa protein in cis.- In vivo transfection by hepatitis A virus synthetic RNA.- RNA recombination.- Recombination between Sindbis virus RNAs.- Homologous RNA recombination allows efficient introduction of site-specific mutations into the genome of Coronavirus MHV-A59 via synthetic co-replicating RNAs.- Targeting of the site of nonhomologous genetic recombination in brome mosaic virus.- Natural recombination in bovine viral diarrhea viruses.- Sequences at the ends of RNA-2 of 16, a recombinant tobravirus.- RNA-protein interactions and host-virus interactions.- Identification and characterization of host factor interactions with cis-acting elements of rubella virus RNA.- Interaction of cellular proteins with the poliovirus 5? noncoding region.- IRES-controlled protein synthesis and genome replication of poliovirus.- Analysis of hepatitis A virus translation in a T7 polymerase-expressing cell line.- Purification and characterization of the U-particle, a cellular constituent whose synthesis is stimulated by mengovirus infection.- B-lymphocytes are predominantly involved in viral propagation of hepatitis C virus (HCV).- Protein expression and virion maturation.- Folding of the mouse hepatitis virus spike protein and its association with the membrane protein.- Assembly and entry mechanisms of Semliki Forest virus.- The interactions of the flavivirus envelope proteins: implications for virus entry and release.- Coronavirus polyprotein processing.- Processing of dengue type 4 and other flavivirus nonstructural proteins.- Nuclear targeting of Semliki Forest virus nsP2.- RNA replication.- Replication and translation of cowpea mosaic virus RNAs are tightly linked.- Alphavirus positive and negative strand RNA synthesis and the role of polyproteins in formation of viral replication complexes.- Nodavirus RNA replication:mechanism and harnessing to vaccinia virus recombinants.- Molecular characterization of Borna virus RNAs.- Genomic organization and expression of astroviruses and calciviruses.- Lelystad virus belongs to a new virus family, comprising lactate dehydrogenase- elevating virus, equine arteritis virus, and simian hemorrhagic fever virus.- Virus receptors.- Recognition of cellular receptors by bovine corona-virus.- Mouse hepatitis virus receptors: more than a single carcinoembryonic antigen.- Host-cell receptors for Sindbis virus.- Cell surface receptor for ecotropic host-range mouse retroviruses: a cationic amino acid transporter.- Virus structure and assembly.- Comparative studies of T = 3 and T = 4 icosahedral RNA insect viruses.- Retroviral RNA packaging: a review.- Structural studies of viruses by electron cryomicroscopy.- Crystallographic and cryo EM analysis of virion-receptor interactions.- Assembly of tobacco mosaic virus and TMV-like pseudovirus particles in Escherichia coli.