Richa Upadhyay is an assistant professor of botany at Mihir Bhoj PG College, Dadri, Gautam Budh Nagar. She received her PhD from Banaras Hindu University, Varanasi, India. Her research interests are in natural product-based drug discovery. She has published several peer-reviewed articles, books, and patents.Chandrashekhar Singh is a distinguished researcher and academic with expertise in plant biotechnology, clinical microbiology, and nanomedicine, currently employed as an assistant professor at People's University, Bhopal, Madhya Pradesh, India. He has contributed significantly to the development of bioinspired therapeutic agents targeting wound healing and antimicrobial resistance. He has held academic positions at Maharishi University of Information Technology, Lucknow, and Sri Agrasen Kanya PG College, Varanasi, and served as a postdoctoral research associate at IIT BHU. His work includes numerous peer-reviewed publications, book chapters, and three patents in nanotechnology and phytotherapy.

• 1. Introduction and Overview of Polyphenol Nutraceuticals 2. Biochemistry and Antioxidant Mechanisms of Polyphenols 3. Pharmaceutical, Biological, and Medical Benefits of Polyphenol-Based Nutraceuticals Derived from Foods, Fruits, Herbs, and Medicinal Plants 4. Extraction Techniques for Polyphenol-Rich Nutraceuticals 5. Molecular Mechanism of Action of Polyphenol Nutraceuticals Targeting Human Disease 6. Method of Synthesis of Polyphenol Nutraceutical Formulation 7. Challenges in the Design of Nutraceuticals 8. Formulation Strategies and Challenges for Polyphenol Nutraceuticals 9. Standardization of the Nutraceutical Products 10. Treatment with Polyphenol Nutraceuticals: Case Studies 11. Advantages, Limitations, Challenges, and Future of Polyphenol Nutraceuticals 12. Polyphenol Nutraceuticals Available on the Market and their Health Benefits 13. Regulatory Considerations, Safety, and Toxicology of Polyphenol Nutraceuticals 14. Pharmacokinetics of Polyphenols 15. Emerging Role of Polyphenols in Nutraceutical Development: Current Insights and Future Directions