Polymorphism in Pharmaceutical Solids

Inbunden, Engelska, 2009

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Using clear and practical examples, Polymorphism of Pharmaceutical Solids, Second Edition presents a comprehensive examination of polymorphic behavior in pharmaceutical development that is ideal for pharmaceutical development scientists and graduate students in pharmaceutical science. This edition focuses on pharmaceutical aspects of polymorphism and solvatomorphism, while systematically explaining their thermodynamic and structural origins. Topics include: Computational methodologiesHigh-throughput screening methodsPharmaceutical cocrystalsThermally-induced and solution-mediated phase transformationsAmorphous solids Crystallography preparation and characterization The amorphous state

Produktinformation

Utgivningsdatum2009-07-27
Mått152 x 229 x 40 mm
Vikt975 g
FormatInbunden
SpråkEngelska
SerieDrugs and the Pharmaceutical Sciences
Antal sidor652
Upplaga2
FörlagTaylor & Francis Inc
ISBN9781420073218

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Tillverkningsteknik inom Naturvetenskap och teknik
Medicin: allmänt inom Medicin
Biologi inom Naturvetenskap och teknik
Tillverkningsindustri inom Ekonomi och ledarskap
Teknik: allmänt inom Naturvetenskap och teknik

1. Thermodynamic and Theoretical Issues. 1.1. Theory and Origin of Polymorphism. 1.2. Application of the Phase Rule. 1.3. Computational Methodologies. 2. Preparative Methods for Polymorphs and Solvatomorphs. 2.1. Classical Methods of Preparation. 2.2. High-Throughput Screening Methods. 3. Structural Properties of Polymorphs and Solvatomorphs. 3.1. Polymorphic Systems. 3.2. Solvatomorphic Systems. 3.3. Pharmaceutical Cocrystals. 4. Characterization Methods for Polymorphs and Solvatomorphs. 4.1. Thermal and Crystallographic. 4.2. Vibrational Spectroscopy. 4.3. Solid-State NMR. 4.4. Solubility and Dissolution Rate. 5. Interconversion of Polymorphs and Solvatomorphs. 5.1. Thermally-Induced and Solution-Mediated Phase Transformations. 5.2. Effects of Secondary Processing. 5.3. Structural Aspects of Molecular Dissymmetry. 5.4. Amorphous Solids.