Polymers for Oral Drug Delivery Technologies

Häftad, Engelska, 2024

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Polymers for Oral Drug Delivery Technologies covers the fundamentals of oral drug delivery and various aspects of polymer technology in oral drug delivery, from classification and synthesis, to applications and regulatory factors. It presents the oral delivery?of therapeutics for treating a number of diseases, along with the challenges of oral drug administration to assure a predictive and reproducible pharmacokinetic profile of active pharmaceutical ingredients (API).

Polymers play an important role to achieve the targeted release profile consistently of an API in vivo by various functionalities like drug protection from gastric juice, fast release and supersaturation or release within a targeted area of the GI tract.

Provides a comprehensive update on the state of polymer technology for oral drug delivery, bringing the reader up-to-speed via a single reference
Covers a range of polymer technology types, including capsule forming polymers, matrix formers, functional polymer coatings, and more
Contains contributions from global experts spanning academia and industry, offering an interdisciplinary and translational approach to polymers for oral drug delivery

Produktinformation

Utgivningsdatum2024-09-30
Mått152 x 229 x 43 mm
Vikt1 000 g
FormatHäftad
SpråkEngelska
SerieWoodhead Publishing Series in Biomaterials
Antal sidor854
FörlagElsevier Science
ISBN9780443137747

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Dr Anilkumar Parambath is Senior R&D Manager of YTY Group, Indorama Corp., Perak, Malaysia. Prior to this, he was R&D Manager, Science & Technology at Unilever (2021-2024); Senior Manager and Head of Capsules Product R&D, ACG Capsules, Mumbai, India (2018-2021) and Principal Investigator for Performance and Specialty Materials at Syngene International Ltd, Bangalore India (2017-2018), where he worked on developing various elastomers, silicones, acrylics and other polymers for biomedical applications. He completed his PhD in Chemistry (Polymer Science) at the University of Kerala, India, and spent 7 years conducting post-doctoral research at Clemson University, USA, French atomic Energy Commission (CEA), France, and the University of British Columbia, Canada. HIs expertise is in polymer science, materials science, green chemistry, nanotechnology, nanomedicine, and biomaterials science. Dr. Parambath has edited three books on polymer biomaterials in drug delivery applications, including two with Elsevier, and has published many books chapters and journal articles. He has two patents to his name. In 2024, he was recognized by the American Chemical Society (ACS) as a Sustainability Star.

Section A. Fundamentals of Oral Drug Delivery1. GI tract environment (e.g. gastric juice, bile salts, pH, amylases, proteases etc.)2. GI tract motility and transport3. Drug absorption and pre-systemic metabolism and PK modelling4. In vitro dissolution and predictive release testing5. Principle characteristics and specification of pharmaceutical polymers6. Regulatory Aspects of Polymers Used and new polymers for Oral MedicationSection B. Role Polymer Technology in Oral Drug Delivery7. Classes/types of polymers used in oral delivery (natural, semi-synthetic, synthetic), their chemical structure and general functionalities8. Role of polymers in Tableting9. Capsule forming Polymers10. Dry and wet Granulation11. Matrix formers12. Functional Polymer Coatings (IR, easy to swallow, enteric etc.)13. Amorphous systems (e.g. HME, SD)14. Micro/Nanoparticles15. Taste masking polymers16. Polymers in Orally disintegrating tablets and Orally dissolving films17. Additive manufacturing (3D printing)18. Mucoadhesive forms19. Gastro-retentive forms20. Polymer blends and additives