Polin and Fox Fetal and Neonatal Physiology, 2-Volume Set

Richard Polin is William T. Speck Professor and Vice-Chair of Pediatrics, Division of Neonatology, Vagelos College of Physicians and Surgeons at Columbia University Irving Medical Center, Morgan Stanley Children's Hospital, New York-Presbyterian, New York.

• Section 1: GENETICS AND EMBRYOLOGY1. Basic Genetic Principles2. Epigenetics3. Gene Regulation During Development4. Basic Embryology5. Regulation of Embryogenesis6. Multiomics in Fetal and Neonatal Development7. The Extracellular Matrix in Development8. Angiogenesis9. Prenatal DiagnosisSection 2: PLACENTA AND INTRAUTERINE ENVIRONMENT10. Placental Development11. Regulation of the Placental Circulation12. Mechanisms of Transfer Across the Human Placenta13. Endocrine and Paracrine Function of the Human Placenta14. Intraamniotic Infection/Inflammation and the Fetal Inflammatory Response Syndrome15. Fetal Origins of Adult Disease16. Placental Function in Intrauterine Growth RestrictionSection 3: DEVELOPMENTAL PHARMACOLOGY17. Basic Pharmacologic Principles18. Principles of Pharmacokinetics19. The Physiology of Placental Drug Disposition20. Pharmacogenomics21. Drug Distribution in Fetal Life22. Drug Transfer During BreastfeedingSection 4: INTRAUTERINE AND POSTNATAL GROWTH23. Placental and Fetal Circulatory, Metabolic, and Transcriptomic Changes Accompanying Fetal Growth Restriction24. Endocrine Factors Affecting Neonatal Growth25. Human Milk Composition and Function in the InfantSection 5: PERINATAL IRON, MINERAL, AND VITAMIN METABOLISM26. Fetal and Neonatal Iron Metabolism27. Fetal and Neonatal Calcium, Phosphorus, and Magnesium Homeostasis28. Zinc in the Fetus and Neonate29. Vitamin A Metabolism in the Fetus and Neonate30. Vitamin E Nutrition in Pregnancy and From Infancy to Early Life31. Vitamin K Metabolism in the Fetus and NeonateSection 6: LIPID METABOLISM32. Maternal-Fetal Transfer of Lipid Metabolites33. Brown Adipose Tissue: Development and Function34. Lipids as an Energy Source for the Premature and Term Neonate35. Ketone Body Metabolism in the Newborn36. Long-Chain Polyunsaturated Fatty Acids in Neurobehavioral DevelopmentSection 7: CARBOHYDRATE METABOLISM37. Glucose Metabolism in the Fetus and Newborn and Methods for Its Investigation38. Role of Glucoregulatory Hormones in Hepatic Glucose Metabolism During the Perinatal Period39. Cell Glucose Transport and Glucose Handling During Fetal and Neonatal DevelopmentSection 8: PROTEIN METABOLISM40. General Concepts of Protein Metabolism41. Placental Transfer and Fetal Requirements of Amino AcidsSection 9: THERMOREGULATION42. Temperature Control in Newborn InfantsSection 10: SKIN43. Embryonic and Fetal Development44. Structure and Function of Newborn SkinSection 11: FETAL AND NEONATAL CARDIOVASCULAR PHYSIOLOGY45. Cardiovascular Development46. Developmental Electrophysiology in the Fetus and Neonate47. Developmental Biology of the Pulmonary Vasculature48. Development of the Gastrointestinal Circulation in the Fetus and Newborn49. Physiology of Congenital Heart Disease in the Neonate50. Regulation of Cardiovascular Function During Fetal and Newborn Life51. Nutritional and Environmental Effects on the Fetal Circulation52. Mechanisms Regulating Closure of the Ductus Arteriosus53. Umbilical CirculationSection 12: THE LUNG54. Normal and Abnormal Structural Development of the Lung55. Regulation of Alveolarization56. Physiologic Mechanisms of Normal and Altered Lung Growth Before and After Birth57. Molecular Mechanisms of Lung Development and Lung Branching Morphogenesis58. Upper Airway Structure, Function, Regulation, and Development59. Regulation of Lower Airway Function60. Functional Development of Respiratory Muscles61. Mechanics of Breathing62. Pulmonary Gas Exchange in the Developing Lung63. Oxygen Transport and Delivery64. Control of Breathing in Fetal Life and Onset and Control of Breathing in the Neonate65. Basic Mechanisms of Oxygen Sensing and Adaptation to Hypoxia66. Mechanisms of Neonatal Lung Injury67. Impaired Lung Growth After Injury in Preterm Lung68. Antenatal Factors That Influence Postnatal Lung Development and Injury69. Regulation of Pulmonary CirculationSection 13: SURFACTANT70. Historical Perspective71. Developmental Biology of Lung Stem Cells72. Surfactant Homeostasis: Composition and Function of Pulmonary Surfactant Lipids and Proteins73. Structure and Development of Alveolar Epithelial Cells74. Regulation of Surfactant-Associated Phospholipid Synthesis and Secretion75. Antenatal Hormonal Therapy for Prevention of Respiratory Distress Syndrome76. Surfactant Treatment77. Genetics and Physiology of Surfactant Dysfunction DisordersSection 14: PHYSIOLOGY OF GASTROINTESTINAL TRACT IN THE FETUS AND NEONATE78. Trophic Factors and Regulation of Gastrointestinal Tract and Liver Development79. Organogenesis of the Gastrointestinal Tract80. Development of Gastric Secretory Function81. Development of the Enteric Nervous System and Gastrointestinal Motility82. Development of the Endocrine and Exocrine Pancreas83. Digestive-Absorptive Functions in Fetuses and Infants84. Development of the MicrobiomeSection 15: LIVER AND BILIRUBIN METABOLISM85. Organogenesis and Histologic Development of the Liver86. Bile Acid Metabolism During Development87. Fetal and Neonatal Bilirubin MetabolismSection 16: THE KIDNEY88. Development of the Kidney: Morphology and Mechanisms89. Functional Development of the Kidney in Utero90. Development and Regulation of Renal Blood Flow in the Neonate91. Postnatal Development of Glomerular Filtration Rate in Neonates92. Renal Transport of Sodium During Development93. Potassium Homeostasis in the Fetus and Neonate94. Role of the Kidney in Calcium and Phosphorus Homeostasis95. Transport of Amino Acids in the Fetus and Neonate96. Organic Anion Transport in the Developing Kidney97. Concentration and Dilution of Urine98. Urinary Acidification99. Response to Nephron Loss in Early DevelopmentSection 17: FLUID AND ELECTROLYTE METABOLISM100. Fluid Distribution in the Fetus and Neonate101. Regulation of Acid-Base Balance in the Fetus and NeonateSection 18: DEVELOPMENTAL HEMATOPOIESIS102. Developmental Biology of Hematopoietic Stem Cells103. Neutropoiesis and Homeostasis104. Developmental Erythropoiesis105. Developmental MegakaryopoiesisSection 19: HEMOSTASIS106. Developmental HemostasisSection 20: DEVELOPMENTAL IMMUNOBIOLOGY107. Host Defense Mechanisms Against Bacteria108. Host Defense Mechanisms Against Fungi109. Host Defense Mechanisms Against Viruses110. T-Cell Development111. B Cell Development112. Mononuclear Phagocyte System113. Normal and Abnormal Neutrophil Physiology in the Fetus and Newborn114. The Complement System of the Fetus and Newborn115. Immunology of Human Milk116. Neonatal Pulmonary Host DefenseSection 21: NEUROLOGY117. Development of the Nervous System118. Mechanisms of Cell Death in the Developing Brain119. Development of the Blood-Brain Barrier120. Developmental Aspects of Pain121. Neonatal Sleep in Brain Development and Injury122. Cerebellar Development-The Impact of Preterm Birth and Comorbidities123. Electroencephalography in the Preterm and Term Infant124. Intraventricular Hemorrhage in the Neonate125. Pathophysiology of Neonatal Cerebral White and Gray Matter Injury126. Fetal and Neonatal Physiology: Cellular and Molecular Mechanisms of Neonatal Brain Injury and Neuroprotection127. Neuroimmune Interaction in Brain Development and Diseases128. Neuroprotective Therapeutic HypothermiaSection 22: SPECIAL SENSORY SYSTEMS IN THE FETUS AND NEONATE129. Early Development of the Human Auditory System130. Gustatory Sensation (Taste)131. Development of OlfactionSection 23: ENDOCRINE FUNCTION132. Hypothalamus: Neuroendometabolic Center133. Growth Factor Regulation of Fetal Growth134. Growth Hormone, Prolactin, and Placental Lactogen in the Fetus and Newborn135. Luteinizing Hormone and Follicle-Stimulating Hormone Secretion in the Fetus and Newborn Infant136. Development of the Hypothalamus-Pituitary- Adrenal Axis in the Fetus137. Fetal and Neonatal Adrenocortical Physiology138. Fetal and Neonatal Thyroid PhysiologySection 24: OVARY AND TESTIS139. Genetics of Sex Determination and Differentiation140. Differentiation of the Ovary141. Testicular Development and DescentSection 25: PATHOPHYSIOLOGY OF NEONATAL DISEASES142. Physiology of Twin-Twin Transfusion143. Physiology of Neonatal Resuscitation144. Pathophysiology of Neonatal Sepsis145. Pathophysiology of Neonatal Hypoglycemia146. Pathophysiology of Cardiomyopathies147. Pathophysiology of Persistent Pulmonary Hypertension of the Newborn148. Pathophysiology of Shock in the Fetus and Neonate149. Pathophysiology of Apnea of Prematurity and Intermittent Hypoxemia150. Pathophysiology of Respiratory Distress Syndrome151. Pathophysiology of Meconium Aspiration Syndrome152. Pathophysiology of Bronchopulmonary Dysplasia153. Pathophysiology of Ventilator-Dependent Infants154. Pathophysiology of Gastroesophageal Reflux155. Pathophysiology and Prevention of Neonatal Necrotizing Enterocolitis156. Pathophysiology of Acute Bilirubin Encephalopathy and Kernicterus Spectrum Disorders157. Pathophysiology of Neonatal Acute Kidney Injury158. The Pathophysiology of Pulmonary Edema in the Developing Lung159. Pathophysiology of Retinopathy of Prematurity160. Pathophysiology of Neonatal Hypoxic-Ischemic Brain Injury161. Pathophysiology of Neonatal Acute Bacterial Meningitis162. Pathophysiology of Neural Tube Defects163. Pathophysiology of Preeclampsia164. Pathophysiology of Preterm Birth165. Climate Change Stressors and Impacts on Pregnancy166. Pathophysiology of Chorioamnionitis: Host Immunity and Microbial Virulence167. Pathophysiology of Genetic Neonatal Disease168. Genetic Variants and Neonatal Disease169. Understanding Fetal and Neonatal Responses to Hypoxia

Review of the previous edition: "The Virginia Apgar Award represents the highest honor that our Section bestows to an individual whose cumulative career accomplishments have had a profound and continuing influence on the well-being of neonates. Richard Polin is the 2021 Virginia Apgar Award recipient, honoring a remarkable career in the field of Neonatology spanning over 40 years.” --AAP Section on Neonatal-Perinatal Medicine, Summer 2021"This is a unique reference and a "must have" for any neonatal caregiver. There are no comparable books that are this comprehensive and describe the physiology and pathophysiology of neonatal disease in such detail. The insight on genetics and future directions of this field of medicine are harbingers of how we will be practicing in the future." --©Doody’s Review Service, 2022, Jay P. Goldsmith, MD (Tulane University School of Medicine) Doody's Score: 5 Stars!