Phytochemicals and Hallmarks of Cancer

Dr. Gautam Sethi is a tenured Associate Professor in the Department of Pharmacology at the Yong Loo Lin School of Medicine, National University of Singapore. His research focuses on elucidating the molecular mechanisms underlying cancer initiation and progression, particularly the activation of oncogenic transcription factors by carcinogens and inflammatory agents, and the identification of novel therapeutic inhibitors. Dr. Sethi has made substantial and direct scholarly contributions to the fields of gut microbiota, cancer pathophysiology, and host–microbiome interactions, with particular emphasis on immunotherapy, tumor microenvironment modulation, metabolic signaling, and therapy response prediction. He has authored numerous peer‑reviewed research and review articles in high‑impact journals, received multiple international awards, and serves on the editorial boards of more than 15 international journals. Dr Lekshmi R. Nath is working as an Associate Professor in the Department of Pharmacognosy at Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, India. She pursued her PhD. in Cancer Research Program. She has more than 50 publications and has been invited as a resource person to many national and international conferences. She is the editorial board member and reviewer of high-impact scientific journals. Her current research interest includes the study of signalling events associated with the fatty liver to Hepatocellular carcinoma, elucidating the role of plant-derived pure compounds in cancer chemoprevention, chemo sensitization, and chemotherapy. She is also exploring the potential of traditional knowledge for cancer and various infectious diseases, their mechanism of action and validation through pre-clinical models

• 1. Phytochemical-mediated targeting of apoptotic pathways in cancer cells2. Targeting autophagy with phytochemicals3. Impact of phytochemicals on cancer cell migration, invasion and angiogenesis4. Phytochemicals as cell cycle modulators5. Phytochemicals to suppress tumor-promoting inflammation6. Impact of phytochemicals on cancer-associated Extracellular matrix(ECM)7. Implication of phytochemicals for cancer immunotherapy8. Phytochemical mediated re-programming of energy metabolism in cancer9. Phytoradiotherapy: An Integrative Approach to Cancer Treatment10. Cancer epigenetic modulation mediated by phytochemicals11. Natural products as anti-cancer drugs: where do we stand now?12. Hurdles in clinical translation plant-derived natural products for cancer therapy

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