Physiological Consequences of Brain Insulin Action

Prof. Dr. André Kleinridders is Professor for Experimental and Molecular Nutritional Medicine at the Institute of Nutritional Science at the University of Potsdam, Germany. Dr. Kleinridders’ research program aims at understanding causes and consequences of brain insulin resistance with implications for diabetes, obesity and neurological disorders. His studies focus on in the interaction of mitochondrial function and insulin signaling and its consequences on energy homeostasis and behavior. Several publications establish Dr. Kleinridders’ unique research focus on the role of brain insulin in metabolic disorders.

• 1 Molecular mechanisms of brain insulin signaling 2 Insulin/IGF signaling in early brain development3 Insulin signaling modulates neuronal metabolism 4 Regulation of glial function by insulin peptides 5 Neuroendocrine interactions in the control of glucose- and energy homeostasis6 Hypothalamic neuronal circuits are modulated by insulin and impact metabolism 7 Insulin and brain reward systems 8 The impact of insulin on brain serotonergic system: consequences on diabetes-associated mood disorders9 Organ cross-talk regulates (brain) insulin action10 Insulin resistance as a risk factor for Alzheimer’s disease 11 Brain insulin action in the control of metabolism in humans 12 Impact of dietary and exercise interventions on brain insulin action and brain function 13 Pharmacological and surgical interventions to improve brain insulin resistance