Physical Measurement of Bone

Dr Christian M Langton Centre for Metabolic Bone Disease, Hull Royal Infirmary, Anlaby Road, Hull HU3 2RW, UK Dr Christopher F Njeh The John Hopkins University, School of Medicine, Division of Radiation Oncology, The Harry and Jeanette Weinberg Building, 401 North Broadway, Suite 1440, Baltimore, MD 21231-1240, USA

• LIST OF CONTRIBUTORS, PREFACE, SECTION 1 INTRODUCTION, 1. ANATOMY, PHYSIOLOGY AND DISEASE, 1.1. Introduction, 1.2. Bone morphology and organization, 1.3. Bone tissue I: the role of bone cells, 1.3.1. The osteoclast, 1.3.2. The osteoblast, 1.3.3. The osteocytes, 1.4. Bone tissue II: the bony matrix, 1.5. Bone composition: mineralization of bone matrix, 1.6. Metabolic disorders of bone, 1.6.1. Introduction, 1.7. Osteoporosis, 1.7.1. Introduction, 1.7.2. Pathophysiology of osteoporosis, 1.7.3. Etiologic factors in osteoporosis, 1.7.4. Epidemiology, 1.8. Summary, References, 2. BIOLOGICAL SAFETY CONSIDERATIONS, 2.1. Introduction, 2.2. Duties and responsibilities, 2.3. Environmental protection, 2.4. Risk assessment, 2.5. Quantifying risk, 2.6. Acceptable risk, 2.7. Risk reduction, 2.8. Hierarchy of risk reduction, 2.9. Specific risks associated with the processing of bone, 2.9.1. Hazard identification, 2.10. Mechanical hazards, 2.10.1. Sawing bone, 2.10.2. Electrical hazards, 2.10.3. Chemical hazards, 2.11. Hazard identification, 2.11.1. Toxicity hazard, 2.11.2. Corrosive hazards, 2.11.3. Exposure limits, 2.11.4. Reactive hazards, 2.11.5. Flammability hazards, 2.12. Extinguishers, 2.13. Risk reduction and control: chemicals, 2.13.1. Fume cupboards, 2.13.2. Biological hazards, 2.14. Hazard categories of biological agents, 2.15. Hazard identification and hazard reduction at source, 2.15.1. For human bone, 2.15.2. For animal bone, 2.16. Prion diseases, 2.17. Biological control measures, 2.17.1. Allergens: control of exposure, 2.17.2. Microbiological safety cabinets, 2.17.3. Disinfectants, 2.17.4. Disinfection of cryostats, 2.17.5. Fumigation, 2.17.6. Disinfection of mechanical testing equipment and machine tools, 2.17.7. Autoclaves, 2.17.8. Disposal of biological waste, 2.17.9. Removal of equipment, 2.18. Use of personal protective equipment, 2.19. General managerial considerations, 2.19.1. Restricted access and permits to work, 2.19.2. Occupational health screening, 2.19.3