Philosophy of Molecular Medicine

Giovanni Boniolo (degrees in Physics and in Philosophy) is Professor of Philosophy of Science and Medical Humanities at the Università di Ferrara, and Anna Boyksen Fellow at the Institute for Advanced Study, Technische Universität München. He has published 13 books (plus 12 books edited) and about 200 research articles.Marco J. Nathan is Assistant Professor of Philosophy at the University of Denver. His work has been published in various philosophical and scientific venues, including Noûs, Philosophy of Science, British Journal for Philosophy of Science, Nephrology Dialysis and Transplantation, Biology and Philosophy, and Synthese.

• Introduction Giovanni Boniolo and Marco J. NathanPart 1: Nature, Origins, and ScopeChap. 1: Molecular medicine: the clinical method enters the lab. What tumor heterogeneity and primary tumor culture teach us Giovanni BonioloChap. 2: Personalized Medicine: Historical Roots of a Medical Model Mariacarla Gadebusch Bondio and Francesco SpöringChap. 3: From the concept of genetic disease to the geneticization of diseases: analyzing and solving the paradox of contemporary medical genetics Marie Darrason Part 2: Explanation Chap. 4: Molecular complexity: Why has psychiatry not been revolutionized by genomics (yet)? Maël LemoineChap. 5: How cancer spreads: reconceptualizing a disease Katherine E. Liu, Alan C. Love, and Michael TravisanoChap. 6: Evolutionary Perspectives on Molecular Medicine: Cancer from an Evolutionary Perspective Anya PlutynskiPart 3: Representation and Modeling Chap. 7: Towards a Notion of Intervention in Big-Data Biology and Molecular Medicine Federico Boem and Emanuele RattiChap. 8: Pathways to the clinic: cancer stem cells and challenges for translational research Melinda Bonnie FaganChap. 9: Counterfactual Reasoning in Molecular Medicine Marco J. NathanPart 4: Inference Chap. 10: Forms of Extrapolation in Molecular Medicine Pierre-Luc Germain and Tudor BaetuChap. 11: Testing Oncological Treatments in the Era of Personalized Medicine David TeiraChap. 12: Opportunities and challenges of molecular epidemiology Federica Russo and Paolo Vineis

Philosophy of Molecular Medicine offers 12 insightful chapters of philosophical and historical reflections on foundational issues in molecular medicine. This edited volume offers a rich introduction to and discussion of important philosophical issues that arise at the interface of basic science, clinical research, and clinical practice.-Sara Green, Springer