Pharmacotherapy of Pulmonary Hypertension

Inbunden, Engelska, 2013

Av Marc Humbert, Oleg V. Evgenov, Johannes-Peter Stasch

4 519 kr

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Pharmacotherapy of Pulmonary Hypertension

Produktinformation

Utgivningsdatum2013-10-16
Mått155 x 235 x 37 mm
Vikt1 032 g
FormatInbunden
SpråkEngelska
SerieHandbook of Experimental Pharmacology
Antal sidor576
Upplaga2013
FörlagSpringer-Verlag Berlin and Heidelberg GmbH & Co. KG
ISBN9783642386633

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Preface.- Part I. Pulmonary hypertension: conceptual bases of the disease. Pulmonary hypertension: definition, classification, and epidemiology. Pulmonary hypertension: pathophysiology and signalling pathways. Pulmonary hypertension: pathology. Pulmonary hypertension: biomarkers. Pulmonary hypertension: animal models.- Part II. Pulmonary hypertension: established therapies. General supportive care. Calcium channel blockers. Prostacyclins. Endothelin receptor antagonists. Phosphodiesterase 5 inhibitors.- Part III. Pulmonary hypertension: novel pathways and emerging therapies Soluble guanylate cyclase stimulators. Therapeutics targeting dysregulated redox equilibrium and endothelial dysfunction (NOXs, sGC activators, GSNOR). Rho-kinase inhibitors. Serotonin transporters and serotonin receptors. PDGF inhibitors. Novel anti-proliferative strategies beyond imatinib. Immunosuppressive agents. Vasoactive peptides. Inhibitors of cGMP/cAMP metabolism (MRP4, MRP5, PDE1). Old targets re-visited. Stem cells and cell based therapy.- Part IV. Conclusions and Outlook. Pulmonary hypertension: evidence-based management in the modern era and future directions.

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