Pharmacology & Pharmacokinetics

Mark Tomlin, BPharm MSc is a consultant pharmacist in critical care at Southampton General Hospital in the UK.

• Section I: Pharmacology.- Introduction.- Mechanism of Drug Action.- Pharmacodynamics.- Section II: Pharmacokinetic Principles.- Introduction.- Drug Absorption.- Drug Distribution.- Drug Metabolism.- Drug Excretion.- Factors Affecting Pharmacokinetics.- Drug Interactions with a Pharmacokinetic Basis.- Deciding to Embark on Therapeutic Monitoring.- Summary.- Section III: Introduction to Specialist Therapeutics.- Drugs Targeting the Gastrointestinal Tract in Critical Care.- Sedation on the Intensive Care Unit.- Non-Opoid Analgesia Within the Intensive Care Unit.- Opiates in Critical Care.

From the reviews: "Part of the Competency-Based Critical Care series, this is an introduction to the basic principles of pharmacology and pharmacokinetics as applied in the critical care setting. ... Medical students or junior trainees wishing to better understand the pharmacology of critical care practice are an appropriate audience for this work ... . This book can be recommended as an effective introduction to broad principles. ... The strength of this work lies in the overview presentations of pharmacology and pharmacokinetic principles." (David J. Dries, Doody's Review Service, April, 2011)