The Editors Turi Aarnes, DVM, MS is Associate Professor at The Ohio State University College of Veterinary Medicine. She is a Diplomate of the American College of Veterinary Anesthesia and Analgesia. Phillip Lerche, BVSc, PhD is Professor – Clinical at The Ohio State University College of Veterinary Medicine. He is a Diplomate of the American College of Veterinary Anesthesia and Analgesia.

• List of Contributors xxivPreface xxvi1 Pharmacokinetics and Pharmacodynamics 1Phillip Lerche and Jeffrey Lakritz2 Pharmacogenetics in Veterinary Anesthesia and Analgesia 13Jeffrey Lakritz3 Veterinary Regulatory Concerns Associated with Anesthesia and Analgesia for Food Animals 31Jeffrey Lakritz4 α2 Receptor Agonists and Antagonists 36Lydia Love5 Phenothiazines and Butyrophenones 55John A.E. Hubbell6 Benzodiazepines 60Sébastien Hyacinthe Bauquier7 Opioid Agonists and Antagonists 75Phillip Lerche8 Barbiturates 96Bonnie L. Hay Kraus9 Induction Drugs 106Jennifer E. Carter10 Inhalant Anesthetic Agents 123Phillip Lerche and Linda Barter11 Non-Steroidal Anti-Inflammatory Drugs 138Craig Willette12 Local Anesthetics 164Turi K. Aarnes13 Anticholinergics 171Phillip Lerche14 CNS Stimulants 177Caitlin Tearney15 Centrally Acting Muscle Relaxants 183Bonnie L. Hay Kraus16 Neuromuscular Blocking Agents 202Manuel Martin-Flores and Daniel M. Sakai17 Anticholinesterase Drugs and Reversal of Neuromuscular Blockade 215Manuel Martin-Flores and Daniel M. Sakai18 Sympathomimetics and Vasopressin 221Phillip Lerche19 Antihypertensives 236Gianluca Bini20 Antiarrhythmic Therapies and Calcium Channel Blockers 252Lance C. Visser21 Peripheral Vasodilators 266Martin Kennedy22 Behavior Drugs 283Erin Wendt-Hornickle23 Adjunctive Analgesic Pharmaceuticals 303Reza Seddighi24 Diuretics 315Andrew Claude25 Antiepileptics 324Laurie Cook and Ashley C. Hechler26 Antihistamines 339S. Bryce Dooley27 Anti-nausea, Antacid, and Prokinetic Drugs 350Phillip Lerche28 Insulin 357Phillip Lerche29 Electrolytes 362Teresa A. Burns30 IV Fluids 370Anusha Balakrishnan31 Blood and Blood Products 382Julien GuillauminIndex 392

The Editors Turi Aarnes, DVM, MS is Associate Professor at The Ohio State University College of Veterinary Medicine. She is a Diplomate of the American College of Veterinary Anesthesia and Analgesia. Phillip Lerche, BVSc, PhD is Professor – Clinical at The Ohio State University College of Veterinary Medicine. He is a Diplomate of the American College of Veterinary Anesthesia and Analgesia.

• List of Contributors xxivPreface xxvi1 Pharmacokinetics and Pharmacodynamics 1Phillip Lerche and Jeffrey Lakritz2 Pharmacogenetics in Veterinary Anesthesia and Analgesia 13Jeffrey Lakritz3 Veterinary Regulatory Concerns Associated with Anesthesia and Analgesia for Food Animals 31Jeffrey Lakritz4 α2 Receptor Agonists and Antagonists 36Lydia Love5 Phenothiazines and Butyrophenones 55John A.E. Hubbell6 Benzodiazepines 60Sébastien Hyacinthe Bauquier7 Opioid Agonists and Antagonists 75Phillip Lerche8 Barbiturates 96Bonnie L. Hay Kraus9 Induction Drugs 106Jennifer E. Carter10 Inhalant Anesthetic Agents 123Phillip Lerche and Linda Barter11 Non-Steroidal Anti-Inflammatory Drugs 138Craig Willette12 Local Anesthetics 164Turi K. Aarnes13 Anticholinergics 171Phillip Lerche14 CNS Stimulants 177Caitlin Tearney15 Centrally Acting Muscle Relaxants 183Bonnie L. Hay Kraus16 Neuromuscular Blocking Agents 202Manuel Martin-Flores and Daniel M. Sakai17 Anticholinesterase Drugs and Reversal of Neuromuscular Blockade 215Manuel Martin-Flores and Daniel M. Sakai18 Sympathomimetics and Vasopressin 221Phillip Lerche19 Antihypertensives 236Gianluca Bini20 Antiarrhythmic Therapies and Calcium Channel Blockers 252Lance C. Visser21 Peripheral Vasodilators 266Martin Kennedy22 Behavior Drugs 283Erin Wendt-Hornickle23 Adjunctive Analgesic Pharmaceuticals 303Reza Seddighi24 Diuretics 315Andrew Claude25 Antiepileptics 324Laurie Cook and Ashley C. Hechler26 Antihistamines 339S. Bryce Dooley27 Anti-nausea, Antacid, and Prokinetic Drugs 350Phillip Lerche28 Insulin 357Phillip Lerche29 Electrolytes 362Teresa A. Burns30 IV Fluids 370Anusha Balakrishnan31 Blood and Blood Products 382Julien GuillauminIndex 392

The Editors Turi Aarnes, DVM, MS is Associate Professor at The Ohio State University College of Veterinary Medicine. She is a Diplomate of the American College of Veterinary Anesthesia and Analgesia. Phillip Lerche, BVSc, PhD is Professor – Clinical at The Ohio State University College of Veterinary Medicine. He is a Diplomate of the American College of Veterinary Anesthesia and Analgesia.

• List of Contributors xxivPreface xxvi1 Pharmacokinetics and Pharmacodynamics 1Phillip Lerche and Jeffrey Lakritz2 Pharmacogenetics in Veterinary Anesthesia and Analgesia 13Jeffrey Lakritz3 Veterinary Regulatory Concerns Associated with Anesthesia and Analgesia for Food Animals 31Jeffrey Lakritz4 α2 Receptor Agonists and Antagonists 36Lydia Love5 Phenothiazines and Butyrophenones 55John A.E. Hubbell6 Benzodiazepines 60Sébastien Hyacinthe Bauquier7 Opioid Agonists and Antagonists 75Phillip Lerche8 Barbiturates 96Bonnie L. Hay Kraus9 Induction Drugs 106Jennifer E. Carter10 Inhalant Anesthetic Agents 123Phillip Lerche and Linda Barter11 Non-Steroidal Anti-Inflammatory Drugs 138Craig Willette12 Local Anesthetics 164Turi K. Aarnes13 Anticholinergics 171Phillip Lerche14 CNS Stimulants 177Caitlin Tearney15 Centrally Acting Muscle Relaxants 183Bonnie L. Hay Kraus16 Neuromuscular Blocking Agents 202Manuel Martin-Flores and Daniel M. Sakai17 Anticholinesterase Drugs and Reversal of Neuromuscular Blockade 215Manuel Martin-Flores and Daniel M. Sakai18 Sympathomimetics and Vasopressin 221Phillip Lerche19 Antihypertensives 236Gianluca Bini20 Antiarrhythmic Therapies and Calcium Channel Blockers 252Lance C. Visser21 Peripheral Vasodilators 266Martin Kennedy22 Behavior Drugs 283Erin Wendt-Hornickle23 Adjunctive Analgesic Pharmaceuticals 303Reza Seddighi24 Diuretics 315Andrew Claude25 Antiepileptics 324Laurie Cook and Ashley C. Hechler26 Antihistamines 339S. Bryce Dooley27 Anti-nausea, Antacid, and Prokinetic Drugs 350Phillip Lerche28 Insulin 357Phillip Lerche29 Electrolytes 362Teresa A. Burns30 IV Fluids 370Anusha Balakrishnan31 Blood and Blood Products 382Julien GuillauminIndex 392