Pharmacological fMRI

Matt Wall graduated with a degree in Natural Sciences from the University of Cambridge. He completed his PhD with Professor David Barford in the Department of Structural Biology at the Institute of Cancer Research. He was a Sir Henry Wellcome Fellow with Professor John Scott FRS (University of Washington, Dept. Pharmacology) prior to starting his group at UCL.Mitul Mehta joined King’s College London as a post-doctoral researcher in Neuroimaging in 2003 with the aim of setting up a research group focused on pharmacological neuroimaging using MRI methodology. He worked with positron emission tomography at Imperial College for a number of years as an MRC Training Fellow before moving to King’s. A Wellcome Trust Value in People Award enabled the transition. His work was recognised by the British Association for Psychopharmacology Young Investigator Award. At King’s his group brought quantitative methods to identify drug mechanisms and classify different compounds and used classic tracking methods (phMRI) to develop assays of drug modulation. These methods are utilised to understand existing compounds as well as assay novel compounds and we have tested various mechanisms, including in collaboration with the pharmaceutical industry.

• 1. Introduction2. Methods in Pharmacological fMRI3. Pre-clinical pharmacological Authors4. Anti-depressants5. Classic Psychedelics6. Non-classic psychedelics7. Pain and analgesics8. Addiction9. Hormones10. Cannabis and Cannabinoids11. fMRI in drug development12. The future of pharmacological fMRI