Pharmacokinetics in Drug Discovery and Development

• BASIC PRINCIPLES: Basic Principles. INDUSTRIAL AND REGULATORY APPLICATIONS: PK/PD Approach. Pharmacokinetics and Metabolism in Drug Discovery and Preclinical Development. Phase I, II, and III FDA Submissions. Bioavailability and Bioequivalence. CLINICAL APPLICATIONS: General Approaches to Clinical Pharmacokinetic Monitoring. Aminoglycosides and Other Antibiotics. Cardiovascular Agents. Psychotropic Agents. Theophylline. Anticonvulsant Agents. RESEARCH APPLICATIONS: Classical Modeling. Non-compartmental Modeling. Physiologically-Based Pharmacokinetic Models. Population Pharmacokinetics. The Linear Systems Approach.

"well written, making many of the approaches understandable even if, like me, the reader is not mathematically gifted. Certainly, this section has stimulated my desire to learn more, and like the Clinical Application section, I will be referring to it regularly"- Peter Lawrence, AstraZeneca, UK, BTS Newsletter, Spring 2003"The authors intend to provide a basic understanding and overview of numerous areas within pharmacokinetics...For anyone with a solid initial training in the field, however, this book should function quite well as a refresher on familiar areas and, more to the intended point, as an introduction to subspecialty areas."-Gregory Reed, PhD, University of Kansas Medical Center