Pharmaceutical Polymer Formulations and its Applications

Raj K. Keservani, PhD is a professor on the Pharmacy faculty at the Chhatrapati Shahu Ji Maharaj Group of Institutions, with over 12 years of teaching experience. He has published over 30 peer-reviewed papers in national and international journals, six patents, over 70 book chapters, three co-authored books, and over 40 edited books. He is also active as a reviewer for several international scientific journals. His research interests include nutraceutical and functional foods, novel drug delivery systems (NDDS), transdermal drug delivery, health science, cancer biology, and neurobiology. Eknath D. Ahire, PhD is an assistant professor in the Department of Pharmaceutics at MET’s Institute of Pharmacy in Bhujbal Knowledge City with over six years of experience. He is a reviewer for 15 reputed international journals and serves as an associate editor and editorial advisory board member with different journals. He has over 110 publications in national and international journals, as well as eight textbooks and six edited books. His research interests include nanotechnology-based drug delivery systems, novel drug delivery systems, and nutraceuticals. Rajesh K. Kesharwani, PhD is an associate professor in the Department of Computer Applications at Nehru Gram Bharati University with over 11 years of experience. He has authored over 55 peer-reviewed articles, 35 book chapters, and 27 edited books with international publishers. He is a reviewer for many international journals and has presented many papers at various national and international conferences. His research interests include medical informatics, protein structure and function prediction, computer-aided drug designing, structural biology, drug delivery, cancer biology, and nanobiotechnology.

• Preface xxiii1 Overview and Introduction of Polymers Used in Pharmaceuticals 1Nikhil Rajnani, Nalini Kurup, Nikita Rajnani and Selvakumar Sambandan1.1 Introduction 21.2 Classification of Polymers 21.3 Ideal Characteristics of Polymer 41.4 Characterization of Polymer 41.5 Applications of Polymers in Drug Delivery System 51.6 Conclusions 11Acknowledgement 11References 112 Biopolymers as Potential Carriers in the Novel Drug Delivery System 17Madhuri D. Deshmukh, Eknath D. Ahire, Moreshwar P. Patil, Prasad Rayte, Sheetal Gosavi, Shruti S. Moarnkar and Amit Kumar Rajora2.1 Introduction 182.2 Classification 182.3 Properties of Biopolymer 222.4 Characterization Techniques of Biopolymer 232.5 Frequently Studied Biopolymers 272.6 Future Prospective 332.7 Conclusion 33Acknowledgements 34References 343 Functional Polymers as Drug Carriers in Pharmaceuticals Development 41Eknath D. Ahire, Gangadhar Magar, Shruti Morankar and Amit Kumar Rajora3.1 Introduction 423.2 Polymers’ Role in Drug Delivery 453.3 Biomaterials for Delivery Systems 463.4 Polymers for Medication Delivery 463.5 How Polymers Release Drugs 493.6 Polymeric System Selection Criteria 503.7 Applications 583.8 Conclusion and Future Trends 63Acknowledgements 64References 644 Nanopolymer for Drug Delivery 71Anju, Mishra Prakash Shyambabu, Amit Kumar Singh and Shanti Bhushan Mishra4.1 Introduction 724.2 Classification of Polymer Nanoparticles 724.3 Polymers Used in the Manufacturing of PNPs 744.4 Conventionally Used Methods for Making Polymeric Nanoparticles (PNPS) 754.5 Pros and Cons of Polymeric Nanoparticles 804.6 Characterizing Polymeric Nanoparticles 814.7 Controlled Drug Delivery Polymeric Nanoparticles 844.8 Applications of Polymeric Nanoparticles 854.9 Recent Advances in the Field of PNPs 904.10 Future Prospects and Challenges 934.11 Conclusion 94Acknowledgement 95References 955 Natural Polymers for Drug Delivery 105Mishra Prakash Shyambabu, Mukul Maurya, Amit Kumar Singh, Pradeep Kumar Vishwakarma and Shanti Bhushan Mishra5.1 Introduction 1065.2 General Methods of Extraction for Natural Polymers 1085.3 Plant-Based Natural Polymers 1115.4 Animal-Based Natural Polymers 1195.5 Microorganism-Based Natural Polymers 1235.6 Marine-Based Natural Polymers 1275.7 Conclusion 131Acknowledgement 131References 1316 Intelligent Drug Delivery Systems for Safe and Effective Cancer Treatment: Smart Bio-Responsive Polymers 143Siva Nageswara Rao Gajula and Lakshmi Vineela Nalla6.1 Introduction 1446.2 Smart Materials with Endogenous Triggering 1476.3 Smart Materials with External Triggers 1516.4 Biological Perspective 1546.5 Conclusion and Future Perspective 164Acknowledgment 165References 1657 Polymers and Their Uses in Drug Delivery 181Shilpa Amit Gajbhiye, Eknath D. Ahire, Moreshwar P. Patil, Preeti R. Meshram and Yogita M. Patil7.1 Introduction 1827.2 A Polymeric Drug Delivery System’s Fundamentals 1847.3 Classification of Polymers 1847.4 Types of Polymers Used Depending Upon Their Inherent Property 1867.5 Traditional Use of Polymers in Drug Delivery 1927.6 Smart Polymers 1927.7 Polymers in Novel Drug Delivery Systems 1937.8 Recent Polymer Drug Delivery System Advances 1947.9 Conclusion 194Acknowledgement 195References 1958 Polymers in Oral Hygiene and Oral Drug Delivery 207Kumari Supriya, Eknath D. Ahire, Amit Kumar Rajora and Shruti Morankar8.1 Introduction 2088.2 Oral Hygiene 2088.3 Polymers 2098.4 History of Oral Polymeric Materials 2108.5 Dental Polymers Natural and Synthetic 2128.6 The Use of Polymers in Oral Hygiene 2128.7 Polymers’ Part in the Oral Delivery of Drug 2148.8 Oral Disease Management 2178.9 Manufacturing of Dental Products 2188.10 Polymers in Oral Health 2188.11 Oral Drug Delivery System 2268.12 Application of Polymers in Oral Dosage Forms 2278.13 Conclusions 234Acknowledgment 235References 2359 Polymers in Controlled Drug Delivery System 241Amruta Balekundri and Eknath D. Ahire9.1 Introduction 2419.2 Controlled Drug Delivery 2449.3 Mechanism of Controlled Drug Delivery System 2459.4 Polymers in Controlled Drug Delivery System 2469.5 Conclusion 250Acknowledgment 250References 25010 Polymers: An Update on Their Use in Ocular Drug Delivery Systems and Other Recent Developments 255Shweta H. Shahare, Hitesh V. Shahare, Yunus N. Ansari, Charulata T. Nemade, Khemchand R. Surana, Rani S. Kankate and Eknath D. Ahire10.1 Introduction 25610.2 Ideal Ophthalmic Drug Delivery System Characteristics 25710.3 Routes of Administration of ODDS 25710.4 Approaches for Ophthalmic Drug Delivery System 25810.5 Polymers in the Delivery of Drug to the Eyes 26310.6 Conclusion 267Acknowledgement 267References 26711 Polymers and Approaches in Dental Preparations 273Hitesh V. Shahare, Yunus N. Ansari, Eknath D. Ahire, Kavita R. Chandramore, Kshtija P. Deshmukh, Shweta H. Shahare and Deepti G. Phadtare11.1 Introduction 27311.2 Polymers Used in Dentistry 27611.3 Branches of Dentistry 27911.4 Properties of Polymers 27911.5 Applications of Polymers in Dentistry 28111.6 Recent Advancements in Use of Polymers in Dentistry 28411.7 Conclusion 286Acknowledgment 286References 28612 Role and Types of Polymers Used in Cosmetics 291Shweta H. Shahare, Bhavesh B. Amrute, Hitesh V. Shahare, Nayana S. Baste, Eknath D. Ahire, Parag A. Pathade and Sandhya Borse12.1 Introduction 29112.2 Classification of Cosmetics 29212.4 Polymers in Cosmetics 29612.5 Natural Polymers 29712.7 Synthetic Polymers 30212.8 Conclusion 304Acknowledgement 304References 30513 Potential Natural Polymers in the Modern Drug Delivery Systems 309Maruti K. Shelar and Shubhangi V. Shekade13.1 Introduction 31013.2 Type of Modern Drug Delivery System 31113.3 Conclusion 326Acknowledgments 326References 32614 Polymers in Nutritional Applications 333Shilpa Amit Gajbhiye, Eknath D. Ahire, Preeti R. Meshram and Yogita M. Patil14.1 Introduction 33314.2 Classification 33414.3 Advantages 33614.4 Disadvantages 33714.5 Application of Nutritional Polymer 33814.6 Current Innovative Research in the Field of Nutritional Polymer 33914.7 Future Perception to Nutritional Polymer Research 34114.8 Conclusion 345Acknowledgement 345References 34615 Green Polymers and Their Uses in Pharmacy 349Pavan Kumar Padarthi, Kore Kakasaheb Jagannath, Varsha Deva, Sudhahar Dharmalingam, Santosh Karajgi, V. Rao, Manchineni Prasada Rao and Senthil Prabhu Rajendran15.1 Introduction 35015.2 Natural (Green) Polymer 35215.3 Future Indications 35915.4 Conclusion 360References 36116 Polymers in Gene Delivery 367Niloufer K. Kotwal, Rishi Pal, Sultana Razia, Jaffar Shaik and Meenakshi Jaiswal16.1 Introduction 36816.2 Application of Polymers in Gene Delivery 37016.3 Methods for Delivering Genes 37016.4 Polymers Used 37116.5 Future Prospective 37916.6 Conclusion 379References 38017 Introduction, Overview and Various Uses of Synthetic Polymers in Pharmacy 385Rajesh Kumar, Jyoti Prakash, Anmol Gautam, Gaurav Dhiman, Pradeep Saha, Dhruv Dev and Mohammad Shahnaz17.1 Introduction 38517.2 Synthetic Polymers in Pharmaceutical Formulation Developments 38817.3 Synthetic Polymer-Conjugates Applications in Pharmaceuticals 39317.4 Applications 39517.5 Future Prospects 39617.6 Conclusion 397References 39718 Semiconducting Polymer 405Senthil Prabhu Rajendran18.1 Introduction 40518.2 Polymers that are Conjugated as Semiconductors 40818.3 Polymers with Semiconducting Properties 40918.4 Applications of Semiconducting Polymers in Pharmaceutical and Medical Sciences Neural Applications 41018.5 Conclusion 413References 41419 Nanostructured Polymer Systems and Pharmacy 421K. Bhaskar Reddy, Vishal Satish Patil, P.S. Minhas, Madhusmruti Khandai, Varinder Soni, V. Ragini, Sanjesh Kumar Gotam Rathi and Dhruv Dev19.1 Introduction 42219.2 Nanostructured Polymers 42419.3 Utilization of Polymeric Nanostructured Systems in the Drug Delivery System Nanocapsules 42519.4 Future Perspective 43219.5 Conclusion 433References 43420 Microstructured Polymer System and Its Application in Pharmacy 441Anasuya Patil, Kavita Vijay, P.S. Minhas, Mahaveer Singh, Ashish Ashokkumar Jaiswal, Sandeep Sharma and Vaibhav Dagaji Aher20.1 Introduction 44220.2 Pharmaceutical Products Using Micro/Nanostructured Polymeric Materials 44420.3 Polymeric Polymers as Pharmaceutical Drug Delivery Matrices 44520.4 Methods for Preparing Nano- and Microparticles 45320.5 Future Perspective 45720.6 Conclusion 458References 458Index 467