Personalized Epigenetics

Inbunden, Engelska, 2015

AvTrygve O. Tollefsbol,Trygve O Tollefsbol

1 319 kr

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Personalized Epigenetics discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures that can guide both disorder and disease prevention and therapy.

The book details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, and noncoding RNA, and the diagnostic, prognostic, and therapeutic potential of the field, it also reviews the impact of the environment on epigenetic variations among individuals and the role of pharmacology and drug development in personalized epigenetics.

Most importantly, the text covers personalized epigenetics from a disease-oriented perspective, presenting chapters that provide advances in widespread disorders or diseases, including diabetes, cancer, autoimmune disorders, obesity, cardiovascular diseases, neurological disorders, and pain management.

Discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures
Details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, and noncoding RNA, and the consequent diagnostic, prognostic and therapeutic potential of the field
Reviews the impact of the environment on epigenetic variations among individuals and the roles of pharmacology and drug development
Devotes several chapters to the advances made in widespread disorders or diseases, including diabetes, cancer, autoimmune disorders, obesity, cardiovascular diseases, neurological disorders, and pain management

Produktinformation

Utgivningsdatum2015-07-29
Mått152 x 229 x 35 mm
Vikt1 090 g
FormatInbunden
SpråkEngelska
Antal sidor610
FörlagElsevier Science
ISBN9780124201354

Tillhör följande kategorier

Medicinsk genetik inom Medicin
Biologi inom Naturvetenskap och teknik

Dr. Tollefsbol is a Distinguished Professor at the University of Alabama at Birmingham. He holds doctorates in molecular biology and osteopathic medicine, trained with National Academy of Science members and has over 200 peer-reviewed publications. Reports highlighting the translatability to the lay public of the discoveries made in his laboratory have appeared in international media representing >50 million readers. Dr. Tollefsbol has been featured as an Investigator in the Spotlight by the NIH as well as a Scientist in the Spotlight by ScienceNow. He is an Associate Editor for Frontiers in Genetics, a contributor to Lewin’s GENES classic textbook and Lead Editor for Elsevier’s Translational Epigenetics Series. Dr. Tollefsbol has been named a “Highly Ranked Scholar worldwide (ScholarGPS). He has been invited for numerous endowed keynote presentations, his research has been highlighted in eScience News and ScienceDaily and he has published 20 scholarly books on topics related to his research.

Section I: Overview1. Epigenetics of Personalized MedicineSection II: Epigenetic Variations Among Individuals2. Inter-individual Variability of DNA Methylation3. Differences in Histone Modifications Between Individuals4. Individual Noncoding RNA Variations: Their Role in Shaping and Maintaining the Epigenetic Landscape5. Personalized Epigenetics: Analysis and Interpretation of DNA Methylation VariationSection III: Bioinformatics of Personalized Epigenetics6. Computational Methods in EpigeneticsSection IV: Diagnostic and Prognostic Epigenetic Approaches to Personalized Medicine7. Epigenetic Biomarkers in Personalized Medicine8. Epigenetic ‘Fingerprint’9. Epigenetics of Personalized ToxicologySection V: Environmental Personalized Epigenetics10. Environmental Contaminants and their Impacts on the Epigenome11. Nutriepigenomics: Personalized Nutrition Meets EpigeneticsSection VI. Pharmacology and Drug Development of Personalized Epigenetics12. Personalized Pharmacoepigenomics13. Personalized Medicine and Epigenetic Drug DevelopmentSection VII: Personalized Epigenetics of Disorders and Disease Management14. Epigenetics and Personalized Pain Management15. Understanding Inter-individual Epigenetic Variations in Obesity and its Management 16. Epigenetic Modification of miRNAs in Cancer17. Managing Autoimmune Disorders Through Personalized Epigenetic Approaches18. Cardiovascular Diseases and Personalized EpigeneticsSection VIII: Challenges and Future Directions19. Future Challenges and Prospects for Personalized Epigenetics

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