Peptide and Protein Design for Biopharmaceutical Applications

Knud J. Jensen, University of Copenhagen, Faculty of Life Sciences, DenmarkProfessor Jensen's research interests cover synthetic bioorganic chemistry, peptide chemistry, carbohydrate chemistry, chemical protein synthesis, solid-phase synthesis and glycobiology.

• List of Contributors. Preface.1. Introduction (Knud J. Jensen)..2. Computational Approaches in Peptide and Protein Design: An Overview (Garland Marshall and Gregory Nikiforovich)..2.1 Introduction.2.2 Basics and Tools.2.3 Computational Study of Cyclopentapeptide Inhibitors of CXCR4.Acknowledgements.References.3. Aspects of Peptidomimetics (VeroniqueMaes and Dirk Tourwe)..3.1 Introduction.3.2 Modified Peptides.3.3 Pseudopeptides.3.4 Secondary Structure Mimics (Excluding Turn Mimics).3.5 Examples of Peptidomimetics.3.6 Conclusion.References.4. Design of Cyclic Peptides (Oliver Demmer, A. O. Frank, and Horst Kessler)..4.1 Introduction.4.2 Peptide Cyclization.4.3 Conformation and Dynamics of Cyclic Peptides.4.4 Concepts in Rational Design of Cyclic Peptides.4.5 Examples of Cyclic Peptides as Drug Candidates.4.6 Conclusion.References.5. Carbohydrates in Design of Peptides and Proteins (Knud J. Jensen and Jesper Brask)..5.1 Introduction.5.2 Configurational and conformational Properties of Carbohydrates.5.3 Carbohydrates in Peptidomimetics.5.4 Glycopeptides.5.5 Carbohydrates as Scaffolds in the Design of Non-Peptide Peptidomimetics.5.6 Sugar Amino Acids.5.7 Cyclodextrin-Peptide Conjugate .5.8 Carboproteins: Model Proteins on Carbohydrate Templates.5.9 Conclusion Remarks.6. De Novo design of proteins (Knud J. Jensen)..6.1 Introduction.6.2 Secondary Structure Elements.6.3 Assembling a Specified Tertiary Structure from Secondary Structure Elements.6.4 Proteins on Templates.6.5 Foldamers.6.6 Biopharmaceutical Applications of Protein De Novo Design.References.7. Design of Insulin Variants for Improved Treatment of Diabetes (Thomas Høeg-Jensen)..7.1 Introduction.7.2 Diabetes Management and the Need for Insulin Engineering.7.3 Insulin Structure.7.4 Prolonged-acting Insulin Solids.7.5 Prolonged-acting Insulin Solutions.7.6 Fast-acting Insulins.7.7 Glucose-sensitive Insulin Preparations.7.8 Alternative Insulin Delivery.7.9 Insulin Mimetics.7.10 Pushing the Limitations of Insulin Engineering.7.11 Conclusion.References.Index..

"This book provides a comprehensive review of the many approaches undertaken over the yearsto develop peptide-based and peptide-mimetic-based drugs." (Journal of Medicinal Chemistry, June 2010)