Pathophysiological Aspects of Proteases in Cancer

Pathophysiological Aspects of Proteases in Cancer provides a comprehensive overview of the multifaceted field of proteases in the cellular environment and focuses on the recently elucidated functions of complex proteolytic systems in physiology and pathophysiology. In 25 chapters this book both gives insight in the general aspects of the role of proteases in cancer, their role as diagnostics and prognostics biomarkers, their impact on chemoresistance and the future cutting edge technologies like cocktail therapies and Cyber Knief technology. Given the breadth and depth of information covered in the respective contributions, the book will be immensely useful for researchers in oncology and working to identify targets for drug development. Multidisciplinary in scope, the book bridges the gap between fundamental and translational research, with applications in the biomedical and pharmaceutical industry, making it a thought-provoking read for basic and applied scientists engaged in biomedical research.

• Gives insight into the spectrum of proteases, protease inhibitors, and protease interactors involved at the cellular and molecular level in cancer development
• Gives a comprehensive overview of the role of proteases in modulating cellular metabolism and chemoresistance to better understand how proteases play in early to the end point in cancer development and metastasis
• Provides a multidisciplinary approach demonstrating the biochemical and signal transduction mechanisms associated with dysregulation of proteases, leading to the manifestation of various diseases
• Highlights the roles and regulation of different types of proteases, as well as their synthetic and endogenous inhibitors
• Bridges the gap between fundamental and translational research, with applications in the biomedical and pharmaceutical industry