Pathological Basis of Oral and Maxillofacial Diseases

The Editors S. R. Prabhu is an Honorary Associate Professor at the University of Queensland School of Dentistry in Brisbane, Australia, a Fellow of the Dental Faculty of all four Royal Surgical Colleges of the UK and Ireland and a former Commonwealth Medical Scholar. Syed Ali Khurram is a Professor of Pathology and Honorary Consultant Pathologist at the University of Sheffield, UK. Omar Kujan is an Associate Professor and the discipline lead in Oral Pathology at UWA Dental School, The University of Western Australia, Perth, Australia. Merva Soluk Tekkesin is a Professor of Oral and Maxillofacial Pathology at Istanbul University, Turkey.

• About the Editors xiList of Contributors xiiiForeword xviiiPreface xixSection 1 Pathology as the Foundation of Medicine 11 Introduction to Pathology 3S. R. Prabhu and Suja Pillai2 Global Scenario, Aetiology and Risk Factors Associated with Oral and Maxillofacial Diseases: An Overview 11Nesa Aurlene Jayadhas and Santosh Kumar Tadakamadla3 The Role of Laboratory Diagnosis in Oral and Maxillofacial Pathology: An Overview 27Hannah Walsh and Daniel J. BrierleySection 2 Homeostasis and Cellular Pathology 394 Homeostasis and Influences of Environment and Nutrition 41A. V. Chalapathi Rao and S. R. Prabhu5 Cellular Structure and Function 51Suheyla Kaya Copyrighted Material6 Cell Injury: Causes, Mechanisms and Responses 64S. R. Prabhu7 The Structure and Function of the Oral Mucosa 82Gargi Sarode and Sachin Sarode8 Cellular Mechanisms of Ageing of Oral Tissues 99Jeremy Lau, Agnieszka Frydrych and Omar Kujan9 Endocrine and Metabolic Dysfunction and Oro- Facial Diseases 108Prazwala Chirravur and Pradeep ChirravurSection 3 Defence Mechanisms Against Disease 13310 Immunity and Host Defence Mechanisms in Oral Health and Disease 135Irene Lafuente-Ibáñez de Mendoza and José M. Aguirre-Urizar11 Immune Dysfunctions Affecting the Oro-Facial Complex 147Yeshwant Rawal12 Pathology of Inflammation and Inflammatory Diseases of the Oro- Facial Complex: An Overview 175S. R. Prabhu13 Cellular and Molecular Mechanisms of Healing of Cutaneous and Oral Mucosal Wounds 196H. Ibrahim Korkmaz and Susan Gibbs14 Healing of the Dental Pulp and Periodontal Tissues, Extraction Socket and BoneFracture 204Sachin Sarode and Gargi SarodeSection 4 Clinical Genetics and Developmental Pathology 22715 The Human Genome and Inheritance: Key Concepts 229Yucel Erbilgin and Muge Sayitoglu16 Heritable Diseases with Examples Involving the Oro- Facial Complex 245Fadi Titinchi and Johan Opperman17 Non- heritable Developmental Disorders with Examples Involving the Oral- Maxillofacial Complex 274John Anthony OzolekSection 5 Infectious and Systemic Diseases 29318 Human Microbiome in Health and Disease with Reference to Dysbiosis in Dental Caries and Periodontal Diseases 295Preethi Balan, Nadeeka Udawatte and Chaminda Jayampath Seneviratne19 Pathology of Infection and Infectious Diseases of the Oro-Facial Complex 310Nagamani Narayana and John Casey20 Oral-systemic Link and Its Impact on General and Oral Health 339Dáire Shanahan and Sarah Jane George21 Orofacial Manifestations of Systemic Diseases: An Overview 362Philip Atkin22 Adverse Drug Reactions in the Orofacial Complex 377Sue-Ching YeohSection 6 Disorders of Cell and Tissue Growth 40723 Neoplasia: Basic Concepts 409Omar Kujan and Philip Sloan24 Molecular Basis of Cancer 415Lalima Tiwari and Omar Kujan25 Host Defences Against Cancer 429Andreia Bufalino26 WHO Classification of Tumours: An Overview 440Muhammed Yakin and Richard Logan27 Dysplasia, Precancer and Oral Potentially Malignant Disorders 449Agnieszka Frydrych and Omar KujanSection 7 Neoplastic Diseases of the Oral Mucosa and Salivary Glands 47528 Global Burden, Risk factors and Pathobiology of Malignant Neoplasms of the Oral Mucosa and the Oropharynx 477Paul Hankinson and Syed Ali Khurram29 Presentation, Diagnosis and Prognosis of Squamous Cell Carcinomas of the Oral Mucosa and Oropharynx 498Selvam Thavaraj and Adam Jones30 Global Burden, Classification, Pathobiology, Genetics and Prognosis of Salivary Gland Neoplasms 531Lucas Lacerda de Souza, Marcio Ajudarte Lopes, Pablo Agustin Vargas and Syed Ali KhurramSection 8 Diseases of the Oral and Maxillofacial Skeleton 56731 Classification and Pathogenesis of Odontogenic and Non- odontogenic Jaw Cysts 569Paul M. Speight and Merva Soluk Tekkesin32 Global Burden, Pathobiology, Genetics and Behaviour of Odontogenic Neoplasms 585Keith Hunter and Merva Soluk Tekkesin33 Pathogenesis and Behaviour of Fibro- osseous and Giant- Cell Lesions of the Jaw Bones 604Lisette Collins and Merva Soluk TekkesinSection 9 Pain Disorders 61534 Pathophysiology of Orofacial Pain 617Janani Ravichandran, Guru O., Ramesh Balasubramaniam and Barry Sessle35 Genetics, Lifestyle and Psychosocial Considerations in Orofacial Pain 639Lasanthini Weerakkody, Jeremy Lau, Kavitha Vegunta, Davis C. Thomas and Ramesh BalasubramaniamIndex 658

An impressive and noteworthy contribution to the field of oral diagnostics, particularly oral pathology, delivering an insightful exploration of the pathological processes underlying orofacial disorders. It succeeds in bridging the often wide gap between foundational biomedical science and clinical application, rendering it a critical resource for students, educators, and dental practitioners alike.- S. M. Balaji Department of Oral and Maxillofacial Surgery, Balaji Dental and Craniofacial Hospital, India.  Review published in Indian Journal of Dental Research (May 25)Scientific advances are presented in a clear and understandable way that the reader would find it easy to grasp rather than having to grapple through journals or very extensive published literature... For dentists looking to study fundamental aspects of oral and maxillofacial diseases, the textbook is a valuable resource. I highly recommend this book to the target readership and to university libraries.-Saman Warnakulasuriya, Emeritus Professor, King's College London, UK. Review published in British Dental Journal (May 25)