Parkinson Disease

Inbunden, Engelska, 2022

Av Roger L. Albin, University of Michigan) Albin, Roger L. (, Roger L Albin

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Parkinson Disease is a comprehensive introduction to the biology and clinical features of Parkinson disease (PD). This book is aimed at clinicians in training, general neurologists seeking a useful guide to PD, and scientists seeking an overview of clinical aspects of PD. Topics covered include nosology of PD, PD epidemiology, pathology and pathophysiology of PD, and theories of PD pathogenesis. Clinical features, including the many non-motor features, natural history of disease progression, clinical pharmacology, and management of PD receive coverage. Important themes are heterogeneity of PD, the multi-focal nature of PD pathology, the diversity of clinical features, dopaminergic signaling and the impacts of dopaminergic deficiency, the importance of non-motor features, limitations of existing treatment modalities, and the necessity of approaching PD as a multi-system disorder. The description and discussion of the many aspects of Parkinson disease (PD) is dogged by the fact that PD is an ambiguous concept. This book intends to be a useful overview, bridging the gap between general textbooks and specific topical reviews.

Produktinformation

Utgivningsdatum2022-10-13
Mått259 x 184 x 24 mm
Vikt862 g
FormatInbunden
SpråkEngelska
SerieCONTEMPORARY NEUROLOGY SERIES
Antal sidor304
FörlagOUP USA
ISBN9780190843014

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Roger L. Albin, M.D. is a graduate of Oberlin College and the University of Pittsburgh School of Medicine. He received clinical and post-doctoral training at the University of Michigan, where his mentors were Anne Young and the late Jack Penney. His primary research interest is the pathophysiology of basal ganglia disorders, including Parkinson disease, Tourette syndrome, and Huntington disease. He is presently Co-Director of the Parkinson Disease & Movement Disorders Division and Director of the Udall Center at the University of Michigan, and Associate Director for Research at the VAAAHS GRECC.

Chapter 1: Definition, History, Nosology, and ClassificationIntroduction and Definition Brief History of PDNosology and Classification SchemeClassification Level 1Classification Level 2Ambiguities and Future DirectionsConclusionChapter 2: EpidemiologyIntroductionPrevalenceIncidenceMortalityRisk FactorsImplications for Understanding Etiopathogenesis and the Future Burden of PDChapter 3: PathologyIntroductionThe Aging BrainGross Pathology, Lewy Pathology, and a-Synucleinopathy Substantia Nigra Pars Compacta PathologyIdiopathic Lewy Body Disease (iLBD) The Braak et al. Staging SystemSynucleinopathy Outside the BrainNon-Synuclein PathologiesChapter 4: Pathophysiology I - Basal Ganglia Architecture and the Standard ModelIntroductionBasic Basal Ganglia ArchitectureThe "Standard" Model of Basal Ganglia Pathophysiology Complexities of Basal Ganglia ArchitectureConclusionChapter 5: Pathophysiology II - Neurotransmitter System DysfunctionsIntroductionNigrostriatal Dopamine Signaling Functions Habit Formation and ChunkingCholinergic Projection System Dysfunctions Serotoninergic System Dysfunctions Conclusions and Future ChallengesChapter 6: Genetics of Parkinson DiseaseIntroductionDominant Forms of PD Recessive Forms of PDGBAPD Genetic Risk Factors Implications of PD Genetic ResearchChapter 7: PathogenesisNeuronal VulnerabilityAlpha-SynucleinThe Prion-Like HypothesisMitochondrial DysfunctionOxidative StressEndolysosomal Dysfunction NeuroinflammationNeuroprotection TrialsConclusionsChapter 8: Prodromal Parkinson DiseaseIntroductionREM Sleep Behavior Disorder Observational StudiesREM Sleep Behavior Disorder Cohort Studies Genetic Cohort StudiesAutonomic FailureFuture DirectionsChapter 9: Clinical Features I - Initial EvaluationPresentation FeaturesNature of Diagnosis and Diagnostic Criteria History and Examination Differential DiagnosisTreatment ResponsivenessDiagnostic AccuracyChapter 10: Clinical Features II - Non-Motor FeaturesIntroductionCognitive ImpairmentsNeuropsychiatric Disorders Sleep DisordersPainFatigueAutonomic Disorders Visual DisordersOral HealthConclusionChapter 11: Clinical Features III - Natural History IntroductionAssessing PD ProgressionPD Progression - Clinically Salient FeaturesSubgroupsNatural History Summary Continuing CareEnd of Life CareChapter 12: Pharmacology I - L-Dopa Pharmacokinetics and PharmacodynamicsIntroductionDopaminergic Neurotransmission L-Dopa PharmacokineticsL-Dopa PharmacodynamicsPeak Dose DyskinesiasInteractions of L-Dopa Pharmacokinetics, Pharmacodynamics, and Disease Progression Summary and Future DirectionsChapter 13: Pharmacology II - Treating Parkinson DiseaseIntroductionUsing L-DopaWhen the Honeymoon Is OverL-Dopa AdjunctsDopamine Agonists Cholinergic AgentsOther Symptomatic TherapiesFuture DirectionsChapter 14: SurgeryIntroductionDeep Brain Stimulation: Rationale and Possible MechanismsDeep Brain Stimulation: ProceduresDeep Brain Stimulation: STN DBS BenefitsDeep Brain Stimulation: GPi DBS Benefits and STN vs GPi DBSDeep Brain Stimulation: Adverse EventsLesional ProceduresCell-Based and Gene TherapiesFuture DirectionsCoda: Looking Ahead