This book constitutes the proceedings of the 4th Pan-African Conference on Pan-African Intelligence and Smart Systems, PAAISS 2025, held in Kumasi, Ghana, during October 15–17, 2025.The 36 full papers included in this volume were carefully reviewed and selected from 91 submissions. They are organized ino the following topical sections: Core Artificial Intelligence: Theory and Foundations; AI-Optimized IoT and Embedded Systems; Applications of AI and Smart IoT; Smart Infrastructure and Intelligent Engineered Systems; AI Ethics, Regulatory and Responsible Usage.