Seth is the cartoonist behind the comic book series Palookaville, which started in the stone age as a pamphlet and is now a hardcover. His comics have appeared in The New York Times Magazine, Best American Comics, and McSweeney's. His illustrations have appeared in many publications, including the cover of The New Yorker, The Walrus, and Canadian Notes & Queries. He is the designer for several classic comics reprint series, notably collections of work by Charles Schulz, John Stanley, and Doug Wright. In 2022, Seth was awarded the Chevalier de l ordre des Arts et des Lettres.