Oxidative Stress

Eustress and Distress

Häftad, Engelska, 2019

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Oxidative Stress: Eustress and Distress presents current knowledge on oxidative stress within the framework of redox biology and translational medicine. It describes eustress and distress in molecular terms and with novel imaging and chemogenetic approaches in four sections:

A conceptual framework for studying oxidative stress.

Processes and oxidative stress responses. Signaling in major enzyme systems (oxidative eustress), and damaging modification of biomolecules (oxidative distress).

The exposome addresses lifelong exposure and impact on health, nutrient sensing, exercise and environmental pollution.

Health and disease processes, including ischemia-reperfusion injury, developmental and psychological disorders, hepatic encephalopathy, skeletal muscle disorders, pulmonary disease, gut disease, organ fibrosis, and cancer.

Oxidative Stress: Eustress and Distress is an informative resource useful for active researchers and students in biochemistry, molecular biology, medicinal chemistry, pharmaceutical science, nutrition, exercise physiology, analytical chemistry, cell biology, pharmacology, clinical medicine, and environmental science.

Characterizes oxidative stress within the framework of redox biology, redox signaling, and medicine
Empowers researchers and students to quantify specific reactants noninvasively, identify redox biomarkers, and advance translational studies
Features contributions from international leaders in oxidative stress and redox biology research

Produktinformation

Utgivningsdatum2019-11-06
Mått191 x 235 x 45 mm
Vikt1 720 g
FormatHäftad
SpråkEngelska
Antal sidor876
FörlagElsevier Science
ISBN9780128186060

Tillhör följande kategorier

Biologi inom Naturvetenskap och teknik
Biokemi inom Naturvetenskap och teknik

Helmut Sies, MD, PhD (hon), studied medicine at the universities of Tübingen, Munich, and Paris. He was the professor and chair of the Institute for Biochemistry and Molecular Biology I at Heinrich-Heine-University Düsseldorf, Germany, where he is now professor emeritus. He is a member of the German National Academy of Sciences Leopoldina and was the president of the North Rhine-Westphalian Academy of Sciences and Arts. He was named ‘Redox Pioneer’; was the president of the Society for Free Radical Research International (SFRRI). Helmut Sies introduced the concept of “Oxidative Stress in 1985, and was the first to reveal hydrogen peroxide as a normal constituent of aerobic cell metabolism. His research interests comprise redox biology, oxidants, antioxidants, micronutrients.

I. Conceptual1. Oxidative Eustress and Oxidative Distress: Introductory Remarks2. Epistemological challenges of the Oxidative Stress Theory of Disease and the problem of biomarkers3. Systems Biology and Network medicine: An Integrated Approach to Redox Biology and Pathobiology4. The Reactive Species InteractomeII. Oxidative Eustress and Distress: Processes and Responses5. Oxidative stress and the early co-evolution of life and biospheric oxygen6. How imaging transforms our understanding of oxidative stress7. In vivo applications of chemogenetics in redox (patho)biology8. Quantification of H2O2 in cells: methods and significance9. The Keap1-Nrf2 pathway: From Mechanism to Medical Applications10. Ferroptosis: physiological and pathophysiological aspects11. Aquaporins: gatekeepers in the borders of oxidative stress and redox signalling12. Extracellular superoxide dismutase (SOD3): an antioxidant or prooxidant in the extracellular space?13. Protein S-glutathionylation and the regulation of cellular functions14. Dual stressor effects of lipid oxidation and antioxidants15. Oxidized phospholipid signaling: distress to eustress16. Redox regulation of protein kinase signaling17. FoxO transcription factors in the control of redox homeostasis and fuel metabolism18. Oxidatively generated DNA base modifications: relation to eustress and distress19. Light-Initiated Oxidative Stress20. Nutritional Protection against Photooxidative Stress in Human Skin and EyeIII. Exposome 21. Mechanisms integrating lifelong exposure and health22. Nutrient Sensing, the Oxidative Stress Response, and Stem Cell Aging23. How exercise induces oxidative eustress24. Metabolomics as a tool to unravel the oxidative stress-induced toxicity of ambient air pollutants25. Traffic-related environmental risk factors and their impact on oxidative stress and cardiovascular healthIV. Oxidative Stress in Health and Disease Processes26. Mitochondrial ROS production during ischemia-reperfusion injury 27. Redox signaling in cellular differentiation28. Redox regulated brain development29. Eustress, Distress, and Oxidative Stress: Promising Pathways for Mind-Body Medicine30. Reactive Oxygen Species and Cancer31. Perspectives of TrxR1-based cancer therapies32. Oxidative/nitrosative stress and hepatic encephalopathy33. ROS Signaling in Complex Systems: The Gut34. Oxidative stress in skeletal muscle: Unravelling the potential beneficial and deleterious roles of reactive oxygen species35. Redox Mechanisms in Pulmonary Disease: Emphasis on Pulmonary Fibrosis36. Dicarbonyl stress and the glyoxalase system37. Redox distress in organ fibrosis: the role of non-coding RNAs