Oxidative Stress and Biomaterials

Inbunden, Engelska, 2016

Av Thomas Dziubla, D Allan Butterfield, USA) Dziubla, Thomas (Chemical and Materials Engineering, College of Engineering, University of Kentucky, Lexington, KY, USA) Butterfield, D Allan (Department of Chemistry, University of Kentucky, Lexington, KY, D. Allan Butterfield

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Oxidative Stress and Biomaterials provides readers with the latest information on biomaterials and the oxidative stress that can pose an especially troubling challenge to their biocompatibility, especially given the fact that, at the cellular level, the tissue environment is a harsh landscape of precipitating proteins, infiltrating leukocytes, released oxidants, and fluctuations of pH which, even with the slightest shift in stasis, can induce a perpetual state of chronic inflammation.

No material is 100% non-inflammatory, non-toxic, non-teratogenic, non-carcinogenic, non-thrombogenic, and non-immunogenic in all biological settings and situations.

In this embattled terrain, the most we can hope for from the biomaterials we design is a type of "meso-compatibility,� a material which can remain functional and benign for as long as required without succumbing to this cellular onslaught and inducing a local inflammatory reaction.

Explores the challenges of designing and using biomaterials in order to minimize oxidative stress, reducing patterns of chronic inflammation and cell death
Brings together the two fields of biomaterials and the biology of oxidative stress
Provides approaches for the design of biomaterials with improved biocompatibility

Produktinformation

Utgivningsdatum2016-06-01
Mått152 x 229 x 25 mm
Vikt680 g
FormatInbunden
SpråkEngelska
SerieWoodhead Publishing Series in Biomaterials
Antal sidor404
FörlagElsevier Science
ISBN9780128032695

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Dr. Thomas Dziubla, Ph.D. is the Associate Gill Professor and Director of Graduate Studies in the Department of Chemical and Materials Engineering at the University of Kentucky. He received his B.S. and Ph.D in Chemical Engineering from Purdue University (1998) and Drexel University (2002), respectively. In 2002–2004, he was an NRSA postdoctoral fellow in the Institute for Environmental Medicine at the University of Pennsylvania’s School of Medicine under the guidance of Dr. Vladimir Muzykantov, where he worked on the design of degradable polymeric nanocarriers for the delivery of antioxidants. His research group is interested in the design of new functional polymeric biomaterials, which can actively control local cellular oxidative stress for improved biomaterial integration and disease treatment. Dr. Dziubla is a member of Society for Biomaterials and American Institute of Chemical Engineers. He holds 8 patents, has authored over 50 peer reviewed publications and has started several companies that are currently commercializing technologies that have originated from his laboratory. Professor, Department of Chemistry and Faculty Associate, Sanders-Brown Center on Aging, University of Kentucky. Also holds the position of Director, Center of Membrane Sciences and Free Radical Biology in Cancer Shared Resources. Professor since 1975 and has co-authored more than 500 articles in Bio-chemistry.

Section I. Basic Principles and Current Understanding Chapter 1. Free Radical Chemistry PrimerChapter 2. Oxidative stress, Inflammation and DiseaseChapter 3. Biomaterial Biocompatibility: Current Understanding and Basics Chapter 4. Oxidative Stress and Biomaterials: The Inflammatory LinkChapter 5. Nanoparticle Toxicity and Environmental ImpactSection II. Analytical Tools Chapter 6. In Vitro –Cell Free Systems for Oxidative stress analysisChapter 7. In Vitro- Cellular Assay for Oxidative stress and Biomaterial ResponseChapter 8. In Vivo Assays for Oxidative stress and Biomaterial BiocompatibilityChapter 9. Emerging Technologies and needs in Oxidative stress analysisSection III. Incorporating Oxidative Stress into Biomaterial Design Chapter 10. Oxidation State as a Bioresponsive TriggerChapter 11. Antioxidant Polymers as a Biomaterial or Therapeutic choiceChapter 12. Metal Nanoparticle AntioxidantsChapter 13. Oxidative Stress and Cancer TherapyChapter 14. Immunomodulatory Biomaterials