Oxidative Stress and Antioxidant Protection

Donald Armstrong is an Emeritus Professor at the State University of New York at Buffalo in Buffalo, NY, USA, Courtesy Research Professor of Ophthalmology at the University of Florida College of Medicine in Gainesville, FL, USA, Visiting Professor of Ophthalmology at Showa University School of Medicine in Tokyo, Japan and Founder and CEO of?Oxidative Stress Associates, Inc. Robert D. Stratton is a retired physician and founder of?Erie Retinal Surgery, Inc., in Erie, PA.?He is also an Adjunct Professor at the University of Florida College of Medicine, Department of Animal Clinical Sciences and a Courtesy Assistant Professor in the Department of Ophthalmology at the University of Florida in Gainesville, FL, USA.

• List of Contributors ixSpecial Recognition xiiiForeword xvPreface xviiSection 1: Introduction1 Introduction to Free Radicals, Inflammation, and Recycling 3Donald Armstrong2 Diagnostic Imaging and Differential Diagnosis 11Robert D. StrattonSection 2: Clinical Correlations on Acute and Chronic Diseases3 Free Radicals: Their Role in Brain Function and Dysfunction 23Natan Gadoth4 Mediators of Neuroinflammation 39Rajiv Tikamdas, Ping Zhang, and Bin Liu5 Oxidative and Nitrative Stress in Schizophrenia 57Anna Dietrich-Muszalska6 The Effects of Hypoxia, Hyperoxia, and Oxygen Fluctuations on Oxidative Signaling in the Preterm Infant and on Retinopathy of Prematurity 77M. Elizabeth Hartnett7 Oxidative Damage in the Retina 93Robert D. Stratton8 The Role of Oxidative Stress in Hearing Loss 115Colleen G. Le Prell and Josef M. Miller9 Disorders of Children 133Hirokazu Tsukahara and Masato Yashiro10 Oxidative Stress in Oral Cavity: Interplay between Reactive Oxygen Species and Antioxidants in Health, Inflammation, and Cancer 155Maurizio Battino, Maria Greabu and Bogdan Calenic11 Oxidative Stress and the Skin 167Christina L. Mitchell12 Oxidative Stress in Osteoarticular Diseases 183María José Alcaraz, Sergio Portal-Núñez, Juan A. Ardura and Pedro Esbrit13 Gene Therapy to Reduce Joint Inflammation in Horses 193Patrick Colahan, Rachael Watson, and Steve Ghivizzani14 Muscle and Oxidative Stress 205Reza Ghiasvand and Mitra Hariri15 Role of Oxidants and Antioxidants in Male Reproduction 221Ashok Agarwal, Hanna Tadros, Aaron Panicker and Eva Tvrdá16 Role of Oxidants and Antioxidants in Female Reproduction 253Ashok Agarwal, Hanna Tadros and Eva Tvrdá17 Reactive Oxygen Species, Oxidative Stress, and Cardiovascular Diseases 281Fatemeh Sharifpanah and Heinrich Sauer18 Oxidative Stress and Antioxidant Imbalance: Respiratory Disorders 307Surinder K. Jindal19 Oxidative Stress and Type 1 Diabetes 319Chao Liu, Clayton E. Mathews, and Jing Chen20 Metabolic Syndrome, Inflammation, and Reactive Oxygen Species in Children and Adults, 329William E. Winter and Janet H. Silverstein21 Oxidative Stress in Chronic Pancreatitis 339Shweta Singh and Bechan Sharma22 Wound Healing and Hyperbaric Oxygen Therapy Physiology: Oxidative Damage and Antioxidant Imbalance 347James R. Wilcox and D. Scott Covington23 Radiobiology and Radiotherapy 357Justin Wray and Judith Lightsey24 Chemotherapy-Mediated Pain and Peripheral Neuropathy: Impact of Oxidative Stress and Inflammation 367Hassan A.N. El-Fawal, Robert Rembisz, Ryyan Alobaidi, and Shaker A. Mousa25 Grape Polyphenol-rich Products with Antioxidant and Anti-inflammatory Properties 389Eduarda Fernandes, Marisa Freitas, Renan C. Chisté, Elena Falqué, and Herminia Domínguez26 Isotonic Oligomeric Proanthocyanidins 403Hanbo Hu and Donald Armstrong27 Superoxide Dismutase Mimics and Other Redox-active Therapeutics 415Ines Batinic-Haberle and Artak Tovmasyan28 Herbal Medicine: Past, Present, and Future with Emphasis on the Use of Some Common Species 471Aneela Afzal and Mohammad Afzal29 Ayurvedic Perspective on Oxidative Stress Management 483Priyanka M. Jadhav30 Clinical Trials and Antioxidant Outcomes 493Carlos Palacio and Arshag D. Mooradian31 Statistical Approaches to Make Decisions in Clinical Experiments 507Albert Vexler and Xiwei ChenIndex 561

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