Robert D. Inman completed his undergraduate degree at Yale University, and his medical degree at McMaster University. He did his training in Internal Medicine at Vanderbilt University and his fellowship in Rheumatology at Cornell University, based at the Hospital for Special Surgery. He worked as a research fellow at the Hammersmith Hospital in London, then was appointed Assistant Professor of Medicine at Cornell University. He moved to the University of Toronto where he was appointed Professor in the Departments of Medicine and Immunology. He was Director of Rheumatology at the University of Toronto 1991-2002. Dr Inman is currently Director of the Arthritis Center of Excellence at the University Health Network, Director of the Spondylitis Program at Toronto Western Hospital, and Deputy Physician in Chief, Research at University Health Network.Joachim Sieper is Head of the Department of Rheumatology at the Charite University Hospital, Berlin, Germany. Prof. Sieper was a Full member of the Medicines Commission 2002-2010, and has been an Extraordinary member of the Drug Commission since 2011.

• 1: Bruce Rothschild & Ernst Feldtkeller: Spondyloarthritis in antiquity and in history 2: Michael Weisman & Lianne Gensler: Epidemiology of Axial Spondyloarthritis 3: Floris van Gaalen, Désirée van der Heijde, & Maxime Dougados: Diagnosis and classification of Axial Spondyloarthritis 4: Martin Rudwaleit & Atul Deodhar: Diagnosis, classification, and management of Peripheral Spondyloarthritis 5: Matthew Brown & John Reveille: Genetics of Spondyloarthritis 6: Robert A. Colbert & Paul Bowness: Immune mechanisms: HLA-B27 7: Dominique Baeten: Immune mechanisms: Innate immunity 8: Maxime Breban & Hill Gaston: Immune mechanisms: Adaptive immunity 9: Marjatta Leirisalo-Repo & John Carter: Infection and Spondyloarthritis 10: Georg Schett & Rik Lories: Pathology: Bone 11: Filip van den Bosch & Muhammad A. Khan: Clinical features 12: Robert Landewe & Astrid van Tubergen: Clinical outcomes 13: Walter Maksymowych & Robert Lambert: Imaging: Sacroiliac joints 14: Kay-Geert A. Hermann & Xenofon Baraliakos: Imaging: Spine 15: Rubén Burgos-Vargas & Shirley Tse: Juvenile-onset Spondyloarthritis 16: James Rosenbaum: Extra-articular manifestations: Uveitis 17: Dirk Elewaut, Heleen Cypers, Matthew L. Stoll, & Charles O. Elsen: Extra-articula manifestations: Inflammatory Bowel Disease 18: Dafna Gladman & Wolf-Henning Boehncke: Extra-articular manifestations: Psoriasis 19: Salih Ozgocmen & Laura Passalent: Treatment: Non-pharmacological 20: Nigil Haroon & Jon Chan: Treatment: Non-Steroidal Anti-inflammatory Drugs in Axial Spondyloarthritis 21: Denis Poddubnyy & Hildrun Haibel: Treatment: DMARDS 22: Juergen Braun & Irene van der Horst-Bruinsma: Treatment: Biologics 23: Heinrich Boehm & Y. Raja Rampersaud: Treatment: Aim and indication of surgical treatment 24: Tore Kristian Kvien, Mikkel Østergaard, & Elisabeth Lie: Patient registries 25: Annelies Boonen: Economic evaluation of diagnosing and treating axial SpA 26: Michael Ward: Physical functioning and work ability 27: Laure Savage & Seoirse Smith: Patient support and advocacy in Axial Spondyloarthritis 28: Tae Hwan Kim, Huji Xu, Chan-Bum Choi, & Feng Huang: Axial Spondyloarthritis in Asia 29: Percival Sampaio-Barros & Rafael Valle Onate: Axial Spondyloarthritis in Latin America 30: Anand Malaviya & Ashok Kumar: Axial Spondyloarthritis in India

The concept of axial spondyloarthritis (axSpA) has undergone major changes in the recent years, and rather than focusing on ankylosing spondylitis which is the end result of a chronic disease process, detecting and managing axial inflammation early have become the major targets. Not only our understanding of the biological basis of axSpA has improved, but also we have much better targeted therapies with which our experience is ever growing. This Oxford Textbook of Axial Spondyloarthritis has been able to do justice to all the aforementioned areas and much more; it is perhaps the first book to cover axSpA with this degree of detail.

Robert D. Inman completed his undergraduate degree at Yale University, and his medical degree at McMaster University. He did his training in Internal Medicine at Vanderbilt University and his fellowship in Rheumatology at Cornell University, based at the Hospital for Special Surgery. He worked as a research fellow at the Hammersmith Hospital in London, then was appointed Assistant Professor of Medicine at Cornell University. He moved to the University of Toronto where he was appointed Professor in the Departments of Medicine and Immunology. He was Director of Rheumatology at the University of Toronto 1991-2002. Dr Inman is currently Director of the Arthritis Center of Excellence at the University Health Network, Director of the Spondylitis Program at Toronto Western Hospital, and Deputy Physician in Chief, Research at University Health Network.Joachim Sieper is Head of the Department of Rheumatology at the Charite University Hospital, Berlin, Germany. Prof. Sieper was a Full member of the Medicines Commission 2002-2010, and has been an Extraordinary member of the Drug Commission since 2011.

• 1: Bruce Rothschild & Ernst Feldtkeller: Spondyloarthritis in antiquity and in history 2: Michael Weisman & Lianne Gensler: Epidemiology of Axial Spondyloarthritis 3: Floris van Gaalen, Désirée van der Heijde, & Maxime Dougados: Diagnosis and classification of Axial Spondyloarthritis 4: Martin Rudwaleit & Atul Deodhar: Diagnosis, classification, and management of Peripheral Spondyloarthritis 5: Matthew Brown & John Reveille: Genetics of Spondyloarthritis 6: Robert A. Colbert & Paul Bowness: Immune mechanisms: HLA-B27 7: Dominique Baeten: Immune mechanisms: Innate immunity 8: Maxime Breban & Hill Gaston: Immune mechanisms: Adaptive immunity 9: Marjatta Leirisalo-Repo & John Carter: Infection and Spondyloarthritis 10: Georg Schett & Rik Lories: Pathology: Bone 11: Filip van den Bosch & Muhammad A. Khan: Clinical features 12: Robert Landewe & Astrid van Tubergen: Clinical outcomes 13: Walter Maksymowych & Robert Lambert: Imaging: Sacroiliac joints 14: Kay-Geert A. Hermann & Xenofon Baraliakos: Imaging: Spine 15: Rubén Burgos-Vargas & Shirley Tse: Juvenile-onset Spondyloarthritis 16: James Rosenbaum: Extra-articular manifestations: Uveitis 17: Dirk Elewaut, Heleen Cypers, Matthew L. Stoll, & Charles O. Elsen: Extra-articula manifestations: Inflammatory Bowel Disease 18: Dafna Gladman & Wolf-Henning Boehncke: Extra-articular manifestations: Psoriasis 19: Salih Ozgocmen & Laura Passalent: Treatment: Non-pharmacological 20: Nigil Haroon & Jon Chan: Treatment: Non-Steroidal Anti-inflammatory Drugs in Axial Spondyloarthritis 21: Denis Poddubnyy & Hildrun Haibel: Treatment: DMARDS 22: Juergen Braun & Irene van der Horst-Bruinsma: Treatment: Biologics 23: Heinrich Boehm & Y. Raja Rampersaud: Treatment: Aim and indication of surgical treatment 24: Tore Kristian Kvien, Mikkel Østergaard, & Elisabeth Lie: Patient registries 25: Annelies Boonen: Economic evaluation of diagnosing and treating axial SpA 26: Michael Ward: Physical functioning and work ability 27: Laure Savage & Seoirse Smith: Patient support and advocacy in Axial Spondyloarthritis 28: Tae Hwan Kim, Huji Xu, Chan-Bum Choi, & Feng Huang: Axial Spondyloarthritis in Asia 29: Percival Sampaio-Barros & Rafael Valle Onate: Axial Spondyloarthritis in Latin America 30: Anand Malaviya & Ashok Kumar: Axial Spondyloarthritis in India

The concept of axial spondyloarthritis (axSpA) has undergone major changes in the recent years, and rather than focusing on ankylosing spondylitis which is the end result of a chronic disease process, detecting and managing axial inflammation early have become the major targets. Not only our understanding of the biological basis of axSpA has improved, but also we have much better targeted therapies with which our experience is ever growing. This Oxford Textbook of Axial Spondyloarthritis has been able to do justice to all the aforementioned areas and much more; it is perhaps the first book to cover axSpA with this degree of detail.

Robert D. Inman completed his undergraduate degree at Yale University, and his medical degree at McMaster University. He did his training in Internal Medicine at Vanderbilt University and his fellowship in Rheumatology at Cornell University, based at the Hospital for Special Surgery. He worked as a research fellow at the Hammersmith Hospital in London, then was appointed Assistant Professor of Medicine at Cornell University. He moved to the University of Toronto where he was appointed Professor in the Departments of Medicine and Immunology. He was Director of Rheumatology at the University of Toronto 1991-2002. Dr Inman is currently Director of the Arthritis Center of Excellence at the University Health Network, Director of the Spondylitis Program at Toronto Western Hospital, and Deputy Physician in Chief, Research at University Health Network.Joachim Sieper is Head of the Department of Rheumatology at the Charite University Hospital, Berlin, Germany. Prof. Sieper was a Full member of the Medicines Commission 2002-2010, and has been an Extraordinary member of the Drug Commission since 2011.

• 1: Bruce Rothschild & Ernst Feldtkeller: Spondyloarthritis in antiquity and in history 2: Michael Weisman & Lianne Gensler: Epidemiology of Axial Spondyloarthritis 3: Floris van Gaalen, Désirée van der Heijde, & Maxime Dougados: Diagnosis and classification of Axial Spondyloarthritis 4: Martin Rudwaleit & Atul Deodhar: Diagnosis, classification, and management of Peripheral Spondyloarthritis 5: Matthew Brown & John Reveille: Genetics of Spondyloarthritis 6: Robert A. Colbert & Paul Bowness: Immune mechanisms: HLA-B27 7: Dominique Baeten: Immune mechanisms: Innate immunity 8: Maxime Breban & Hill Gaston: Immune mechanisms: Adaptive immunity 9: Marjatta Leirisalo-Repo & John Carter: Infection and Spondyloarthritis 10: Georg Schett & Rik Lories: Pathology: Bone 11: Filip van den Bosch & Muhammad A. Khan: Clinical features 12: Robert Landewe & Astrid van Tubergen: Clinical outcomes 13: Walter Maksymowych & Robert Lambert: Imaging: Sacroiliac joints 14: Kay-Geert A. Hermann & Xenofon Baraliakos: Imaging: Spine 15: Rubén Burgos-Vargas & Shirley Tse: Juvenile-onset Spondyloarthritis 16: James Rosenbaum: Extra-articular manifestations: Uveitis 17: Dirk Elewaut, Heleen Cypers, Matthew L. Stoll, & Charles O. Elsen: Extra-articula manifestations: Inflammatory Bowel Disease 18: Dafna Gladman & Wolf-Henning Boehncke: Extra-articular manifestations: Psoriasis 19: Salih Ozgocmen & Laura Passalent: Treatment: Non-pharmacological 20: Nigil Haroon & Jon Chan: Treatment: Non-Steroidal Anti-inflammatory Drugs in Axial Spondyloarthritis 21: Denis Poddubnyy & Hildrun Haibel: Treatment: DMARDS 22: Juergen Braun & Irene van der Horst-Bruinsma: Treatment: Biologics 23: Heinrich Boehm & Y. Raja Rampersaud: Treatment: Aim and indication of surgical treatment 24: Tore Kristian Kvien, Mikkel Østergaard, & Elisabeth Lie: Patient registries 25: Annelies Boonen: Economic evaluation of diagnosing and treating axial SpA 26: Michael Ward: Physical functioning and work ability 27: Laure Savage & Seoirse Smith: Patient support and advocacy in Axial Spondyloarthritis 28: Tae Hwan Kim, Huji Xu, Chan-Bum Choi, & Feng Huang: Axial Spondyloarthritis in Asia 29: Percival Sampaio-Barros & Rafael Valle Onate: Axial Spondyloarthritis in Latin America 30: Anand Malaviya & Ashok Kumar: Axial Spondyloarthritis in India

The concept of axial spondyloarthritis (axSpA) has undergone major changes in the recent years, and rather than focusing on ankylosing spondylitis which is the end result of a chronic disease process, detecting and managing axial inflammation early have become the major targets. Not only our understanding of the biological basis of axSpA has improved, but also we have much better targeted therapies with which our experience is ever growing. This Oxford Textbook of Axial Spondyloarthritis has been able to do justice to all the aforementioned areas and much more; it is perhaps the first book to cover axSpA with this degree of detail.